Found 37 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011259
(CHEMBL3260362)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccc(nc1)N1CCOCC1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C23H22N6O4S/c30-23(18-11-17-14-27-28-22(17)25-13-18)26-12-16-1-3-19(4-2-16)34(31,32)20-5-6-21(24-15-20)29-7-9-33-10-8-29/h1-6,11,13-15H,7-10,12H2,(H,26,30)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50438936
(CHEMBL2420629 | GNE-617)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011266
(CHEMBL3260358)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011267
(CHEMBL3260359)Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O4S/c22-21(23,24)32-16-2-1-3-18(9-16)33(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011268
(CHEMBL3260357)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C20H14F2N4O3S/c21-15-6-16(22)8-18(7-15)30(28,29)17-3-1-12(2-4-17)9-24-20(27)14-5-13-11-25-26-19(13)23-10-14/h1-8,10-11H,9H2,(H,24,27)(H,23,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011269
(CHEMBL3260364)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1cnc2ccccc2c1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C23H17N5O3S/c29-23(18-9-17-13-27-28-22(17)25-12-18)26-11-15-5-7-19(8-6-15)32(30,31)20-10-16-3-1-2-4-21(16)24-14-20/h1-10,12-14H,11H2,(H,26,29)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011272
(CHEMBL3260366)Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C20H20N6O3S/c1-2-7-26-13-18(12-24-26)30(28,29)17-5-3-14(4-6-17)9-22-20(27)16-8-15-11-23-25-19(15)21-10-16/h3-6,8,10-13H,2,7,9H2,1H3,(H,22,27)(H,21,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011271
(CHEMBL3260360)Show SMILES FC(F)(F)c1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C20H14F3N5O3S/c21-20(22,23)15-6-17(11-24-10-15)32(30,31)16-3-1-12(2-4-16)7-26-19(29)14-5-13-9-27-28-18(13)25-8-14/h1-6,8-11H,7H2,(H,26,29)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011273
(CHEMBL3260361)Show SMILES Clc1cncc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C19H14ClN5O3S/c20-15-6-17(11-21-10-15)29(27,28)16-3-1-12(2-4-16)7-23-19(26)14-5-13-9-24-25-18(13)22-8-14/h1-6,8-11H,7H2,(H,23,26)(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011274
(CHEMBL3260363)Show SMILES CN(C)c1ccc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H20N6O3S/c1-27(2)19-8-7-18(13-22-19)31(29,30)17-5-3-14(4-6-17)10-24-21(28)16-9-15-12-25-26-20(15)23-11-16/h3-9,11-13H,10H2,1-2H3,(H,24,28)(H,23,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50438966
(CHEMBL2420667)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1ccc2nccn2c1 Show InChI InChI=1S/C21H17N3O3S/c25-21(17-8-11-20-22-12-13-24(20)15-17)23-14-16-6-9-19(10-7-16)28(26,27)18-4-2-1-3-5-18/h1-13,15H,14H2,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Rattus norvegicus) | BDBM50438936
(CHEMBL2420629 | GNE-617)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat NAMPT after 30 mins by mass spectrometry-based analysis |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nicotinamide phosphoribosyltransferase
(Mus musculus) | BDBM50438936
(CHEMBL2420629 | GNE-617)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of mouse NAMPT after 30 mins by mass spectrometry-based analysis |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50438967
(CHEMBL2420666)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCCCC1)c1ccc2nccn2c1 Show InChI InChI=1S/C20H22N4O3S/c25-20(17-6-9-19-21-10-13-23(19)15-17)22-14-16-4-7-18(8-5-16)28(26,27)24-11-2-1-3-12-24/h4-10,13,15H,1-3,11-12,14H2,(H,22,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Rattus norvegicus) | BDBM50011266
(CHEMBL3260358)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of rat NAMPT after 30 mins by mass spectrometry-based analysis |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011275
(CHEMBL3260347)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C20H16N4O3S/c25-20(16-10-15-13-23-24-19(15)21-12-16)22-11-14-6-8-18(9-7-14)28(26,27)17-4-2-1-3-5-17/h1-10,12-13H,11H2,(H,22,25)(H,21,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Mus musculus) | BDBM50011266
(CHEMBL3260358)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of mouse NAMPT after 30 mins by mass spectrometry-based analysis |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011276
(CHEMBL3260367)Show SMILES CC(C)n1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C20H20N6O3S/c1-13(2)26-12-18(11-24-26)30(28,29)17-5-3-14(4-6-17)8-22-20(27)16-7-15-10-23-25-19(15)21-9-16/h3-7,9-13H,8H2,1-2H3,(H,22,27)(H,21,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011277
(CHEMBL3260346)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCCCC1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C19H21N5O3S/c25-19(16-10-15-13-22-23-18(15)20-12-16)21-11-14-4-6-17(7-5-14)28(26,27)24-8-2-1-3-9-24/h4-7,10,12-13H,1-3,8-9,11H2,(H,21,25)(H,20,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011278
(CHEMBL3260356 | US10696692, Example 269)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CC2(C1)CCOCC2)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C21H23N5O4S/c27-20(17-9-16-12-24-25-19(16)22-11-17)23-10-15-1-3-18(4-2-15)31(28,29)26-13-21(14-26)5-7-30-8-6-21/h1-4,9,11-12H,5-8,10,13-14H2,(H,23,27)(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011279
(CHEMBL3260365)Show SMILES CCn1cc(cn1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C19H18N6O3S/c1-2-25-12-17(11-23-25)29(27,28)16-5-3-13(4-6-16)8-21-19(26)15-7-14-10-22-24-18(14)20-9-15/h3-7,9-12H,2,8H2,1H3,(H,21,26)(H,20,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011280
(CHEMBL3260353 | US10696692, Example 156)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCC(CC1)N1CCCC1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C23H28N6O3S/c30-23(19-13-18-16-26-27-22(18)24-15-19)25-14-17-3-5-21(6-4-17)33(31,32)29-11-7-20(8-12-29)28-9-1-2-10-28/h3-6,13,15-16,20H,1-2,7-12,14H2,(H,25,30)(H,24,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011281
(CHEMBL3260355 | US10696692, Example 9)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCOCC1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C18H19N5O4S/c24-18(15-9-14-12-21-22-17(14)19-11-15)20-10-13-1-3-16(4-2-13)28(25,26)23-5-7-27-8-6-23/h1-4,9,11-12H,5-8,10H2,(H,20,24)(H,19,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011282
(CHEMBL3259825)Show SMILES NC1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C19H22N6O3S/c20-16-5-7-25(8-6-16)29(27,28)17-3-1-13(2-4-17)10-22-19(26)15-9-14-12-23-24-18(14)21-11-15/h1-4,9,11-12,16H,5-8,10,20H2,(H,22,26)(H,21,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011283
(CHEMBL3260351)Show SMILES COC1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C20H23N5O4S/c1-29-17-6-8-25(9-7-17)30(27,28)18-4-2-14(3-5-18)11-22-20(26)16-10-15-13-23-24-19(15)21-12-16/h2-5,10,12-13,17H,6-9,11H2,1H3,(H,22,26)(H,21,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011284
(CHEMBL3260350)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCC(CC1)C#N)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C20H20N6O3S/c21-10-14-5-7-26(8-6-14)30(28,29)18-3-1-15(2-4-18)11-23-20(27)17-9-16-13-24-25-19(16)22-12-17/h1-4,9,12-14H,5-8,11H2,(H,23,27)(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011285
(CHEMBL3260352 | US10696692, Example 30)Show SMILES OC1CCN(CC1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C19H21N5O4S/c25-16-5-7-24(8-6-16)29(27,28)17-3-1-13(2-4-17)10-21-19(26)15-9-14-12-22-23-18(14)20-11-15/h1-4,9,11-12,16,25H,5-8,10H2,(H,21,26)(H,20,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011286
(CHEMBL3260354 | US10696692, Example 117)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1COC1)c1cnc2[nH]ncc2c1 Show InChI InChI=1S/C21H24N6O4S/c28-21(17-9-16-12-24-25-20(16)22-11-17)23-10-15-1-3-19(4-2-15)32(29,30)27-7-5-26(6-8-27)18-13-31-14-18/h1-4,9,11-12,18H,5-8,10,13-14H2,(H,23,28)(H,22,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011287
(CHEMBL3260344)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1ccc2[nH]ncc2n1 Show InChI InChI=1S/C20H16N4O3S/c25-20(18-11-10-17-19(23-18)13-22-24-17)21-12-14-6-8-16(9-7-14)28(26,27)15-4-2-1-3-5-15/h1-11,13H,12H2,(H,21,25)(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011288
(CHEMBL3260348)Show SMILES Cn1ncc2cc(cnc12)C(=O)NCc1ccc(cc1)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C21H18N4O3S/c1-25-20-16(14-24-25)11-17(13-22-20)21(26)23-12-15-7-9-19(10-8-15)29(27,28)18-5-3-2-4-6-18/h2-11,13-14H,12H2,1H3,(H,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011289
(CHEMBL3260349)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C21H17N3O3S/c25-21(17-12-16-10-11-22-20(16)23-14-17)24-13-15-6-8-19(9-7-15)28(26,27)18-4-2-1-3-5-18/h1-12,14H,13H2,(H,22,23)(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011290
(CHEMBL3260343)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)N1CCCCC1)c1ccc2[nH]ncc2c1 Show InChI InChI=1S/C20H22N4O3S/c25-20(16-6-9-19-17(12-16)14-22-23-19)21-13-15-4-7-18(8-5-15)28(26,27)24-10-2-1-3-11-24/h4-9,12,14H,1-3,10-11,13H2,(H,21,25)(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011291
(CHEMBL3260345)Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)c1cc2cn[nH]c2cn1 Show InChI InChI=1S/C20H16N4O3S/c25-20(18-10-15-12-23-24-19(15)13-21-18)22-11-14-6-8-17(9-7-14)28(26,27)16-4-2-1-3-5-16/h1-10,12-13H,11H2,(H,22,25)(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of C-terminal His-6-tagged full length human NAMPT expressed in Escherichia coli (DE3) cells after 30 mins by mass spectrometry-based anal... |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50438936
(CHEMBL2420629 | GNE-617)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nicotinamide phosphoribosyltransferase
(Mus musculus) | BDBM50438936
(CHEMBL2420629 | GNE-617)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1 Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50011266
(CHEMBL3260358)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of NAMPT in human PC3 cells assessed as reduction in NAD level after 48 hrs by mass spectrometry |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Mus musculus) | BDBM50011266
(CHEMBL3260358)Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(CNC(=O)c2cnc3[nH]ncc3c2)cc1 Show InChI InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
Forma Therapeutics, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of NAMPT in mouse cells assessed as reduction in NAD level after 48 hrs by mass spectrometry |
Bioorg Med Chem Lett 23: 5488-97 (2013)
Article DOI: 10.1016/j.bmcl.2013.08.074
BindingDB Entry DOI: 10.7270/Q2DF6SQ1 |
More data for this
Ligand-Target Pair | |
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