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PubMed code 24113240

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 4


(GUINEA PIG)
BDBM50442803
PNG
(CHEMBL2440453)
Show SMILES CC(O)CCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O3/c1-16(26)7-11-24-12-8-17(9-13-24)15-23-21(27)20-18-5-2-3-6-19(18)25-10-4-14-28-22(20)25/h2-3,5-6,16-17,26H,4,7-15H2,1H3,(H,23,27)
PDB

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.794n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Bioorg Med Chem 21: 7134-45 (2013)


Article DOI: 10.1016/j.bmc.2013.09.004
BindingDB Entry DOI: 10.7270/Q2G44RRT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(GUINEA PIG)
BDBM85026
PNG
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3ccccc23)CC1
Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26)
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DrugBank
MCE
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Bioorg Med Chem 21: 7134-45 (2013)


Article DOI: 10.1016/j.bmc.2013.09.004
BindingDB Entry DOI: 10.7270/Q2G44RRT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(GUINEA PIG)
BDBM50442804
PNG
(CHEMBL2440452)
Show SMILES O=C(NCC1CCNCC1)c1c2OCCCn2c2ccccc12
Show InChI InChI=1S/C18H23N3O2/c22-17(20-12-13-6-8-19-9-7-13)16-14-4-1-2-5-15(14)21-10-3-11-23-18(16)21/h1-2,4-5,13,19H,3,6-12H2,(H,20,22)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
63n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Bioorg Med Chem 21: 7134-45 (2013)


Article DOI: 10.1016/j.bmc.2013.09.004
BindingDB Entry DOI: 10.7270/Q2G44RRT
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(GUINEA PIG)
BDBM50442805
PNG
(CHEMBL2440451)
Show SMILES CCCCN1CCC(CNC(=O)c2c3OCCCn3c3cc(O)ccc23)CC1
Show InChI InChI=1S/C22H31N3O3/c1-2-3-9-24-11-7-16(8-12-24)15-23-21(27)20-18-6-5-17(26)14-19(18)25-10-4-13-28-22(20)25/h5-6,14,16,26H,2-4,7-13,15H2,1H3,(H,23,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
794n/an/an/an/an/an/an/an/a



University of Oslo

Curated by ChEMBL


Assay Description
Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes


Bioorg Med Chem 21: 7134-45 (2013)


Article DOI: 10.1016/j.bmc.2013.09.004
BindingDB Entry DOI: 10.7270/Q2G44RRT
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%