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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM16673 (4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | 114 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107675 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 142 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107677 (1-(3-Chloro-4-fluorophenyl)-3-(3-(methyl (2-methyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 232 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107675 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 271 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107673 (1-(3-(6-Chloro-2-methylpyrimidin-4-ylamino)phenyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 298 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107677 (1-(3-Chloro-4-fluorophenyl)-3-(3-(methyl (2-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 366 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107674 (1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morp...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 626 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107673 (1-(3-(6-Chloro-2-methylpyrimidin-4-ylamino)phenyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 722 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107674 (1-(3-Chloro-4-fluorophenyl)-3-(3-(2-methyl- 6-morp...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107678 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107678 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107679 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.99E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107679 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(methy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.28E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM107676 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.17E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM107676 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(3-(2- me...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Shanghai Institute of Pharmaceutical Industry, 1111 Zhongshan North One Road, Hongkou District, Shanghai, 200437, China | Assay Description Compounds were prepared in DMSO at 10mmol/L and serially diluted in a 96-well plate as the source plate. The intermediate plate consists of 4µL... | Chem Biol Drug Des 83: 27-36 (2014) Article DOI: 10.1111/cbdd.12198 BindingDB Entry DOI: 10.7270/Q2VH5MHM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
