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PubMed code 24332090

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50005206
PNG
(CHEMBL3099788)
Show SMILES Cc1ccc(=O)n(c1)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C20H26N2O2/c1-17-6-11-20(23)22(16-17)18-7-9-19(10-8-18)24-15-5-14-21-12-3-2-4-13-21/h6-11,16H,2-5,12-15H2,1H3
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PubMed
n/an/a 4.07E+3n/an/an/an/an/an/a



Zhejiang Academy of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin) up to 60 mins by ADP-Glo assay

Bioorg Med Chem Lett 24: 220-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.038
BindingDB Entry DOI: 10.7270/Q2PZ5BB0
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50005205
PNG
(CHEMBL3099794)
Show SMILES Cc1ccc(=O)n(c1)-c1ccc(OCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C21H28N2O2/c1-18-7-12-21(24)23(17-18)19-8-10-20(11-9-19)25-16-6-5-15-22-13-3-2-4-14-22/h7-12,17H,2-6,13-16H2,1H3
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PubMed
n/an/a 5.21E+3n/an/an/an/an/an/a



Zhejiang Academy of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin) up to 60 mins by ADP-Glo assay

Bioorg Med Chem Lett 24: 220-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.038
BindingDB Entry DOI: 10.7270/Q2PZ5BB0
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50005207
PNG
(CHEMBL3099785)
Show SMILES CN(C)CCCOc1ccc(cc1)-n1cc(C)ccc1=O
Show InChI InChI=1S/C17H22N2O2/c1-14-5-10-17(20)19(13-14)15-6-8-16(9-7-15)21-12-4-11-18(2)3/h5-10,13H,4,11-12H2,1-3H3
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n/an/a 1.42E+4n/an/an/an/an/an/a



Zhejiang Academy of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin) up to 60 mins by ADP-Glo assay

Bioorg Med Chem Lett 24: 220-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.038
BindingDB Entry DOI: 10.7270/Q2PZ5BB0
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50005204
PNG
(CHEMBL3099800)
Show SMILES Cc1ccc(=O)n(c1)-c1ccc(OCCCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H30N2O2/c1-19-8-13-22(25)24(18-19)20-9-11-21(12-10-20)26-17-7-3-6-16-23-14-4-2-5-15-23/h8-13,18H,2-7,14-17H2,1H3
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n/an/a 1.62E+4n/an/an/an/an/an/a



Zhejiang Academy of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin) up to 60 mins by ADP-Glo assay

Bioorg Med Chem Lett 24: 220-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.038
BindingDB Entry DOI: 10.7270/Q2PZ5BB0
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50005208
PNG
(CHEMBL3099806)
Show SMILES Cc1ccc(=O)n(c1)-c1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C19H24N2O2/c1-16-5-10-19(22)21(15-16)17-6-8-18(9-7-17)23-14-13-20-11-3-2-4-12-20/h5-10,15H,2-4,11-14H2,1H3
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n/an/a 5.43E+4n/an/an/an/an/an/a



Zhejiang Academy of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin) up to 60 mins by ADP-Glo assay

Bioorg Med Chem Lett 24: 220-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.038
BindingDB Entry DOI: 10.7270/Q2PZ5BB0
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))		BDBM50005201
PNG
(AMR-69 | PIRFENIDONE)
Show SMILES Cc1ccc(=O)n(c1)-c1ccccc1
Show InChI InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
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MCE
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PubMed
n/an/a 1.65E+5n/an/an/an/an/an/a



Zhejiang Academy of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of p38alpha (unknown origin) up to 60 mins by ADP-Glo assay

Bioorg Med Chem Lett 24: 220-3 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.038
BindingDB Entry DOI: 10.7270/Q2PZ5BB0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%