Found 8 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
N-arachidonyl glycine receptor
(Homo sapiens (Human)) | BDBM50448075
(CHEMBL1258979)Show SMILES CC(C)=C[C@H]1C[C@]2(C)[C@H](CC[C@@]3(C)[C@H]2CC[C@H]2Cc4c([nH]c5ccccc45)[C@]32C)O1 |r,wU:11.11,6.6,8.33,13.14,wD:16.17,27.32,4.3,(32.2,-12.88,;30.67,-12.87,;29.92,-11.54,;29.89,-14.18,;28.36,-14.17,;27.46,-12.9,;25.97,-13.36,;25.95,-11.85,;25.95,-14.93,;24.6,-15.69,;23.27,-14.91,;23.28,-13.37,;23.27,-11.84,;24.63,-12.61,;24.63,-11.06,;23.29,-10.28,;21.95,-11.05,;20.48,-10.57,;19.59,-11.84,;20.48,-13.08,;19.57,-14.32,;18.11,-13.84,;16.79,-14.61,;15.46,-13.84,;15.46,-12.31,;16.78,-11.54,;18.11,-12.3,;21.95,-12.6,;21.94,-14.13,;27.43,-15.42,)| Show InChI InChI=1S/C28H37NO/c1-17(2)14-19-16-26(3)23-11-10-18-15-21-20-8-6-7-9-22(20)29-25(21)28(18,5)27(23,4)13-12-24(26)30-19/h6-9,14,18-19,23-24,29H,10-13,15-16H2,1-5H3/t18-,19-,23-,24-,26-,27-,28+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins ... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
G-protein coupled receptor 55
(Homo sapiens (Human)) | BDBM50448075
(CHEMBL1258979)Show SMILES CC(C)=C[C@H]1C[C@]2(C)[C@H](CC[C@@]3(C)[C@H]2CC[C@H]2Cc4c([nH]c5ccccc45)[C@]32C)O1 |r,wU:11.11,6.6,8.33,13.14,wD:16.17,27.32,4.3,(32.2,-12.88,;30.67,-12.87,;29.92,-11.54,;29.89,-14.18,;28.36,-14.17,;27.46,-12.9,;25.97,-13.36,;25.95,-11.85,;25.95,-14.93,;24.6,-15.69,;23.27,-14.91,;23.28,-13.37,;23.27,-11.84,;24.63,-12.61,;24.63,-11.06,;23.29,-10.28,;21.95,-11.05,;20.48,-10.57,;19.59,-11.84,;20.48,-13.08,;19.57,-14.32,;18.11,-13.84,;16.79,-14.61,;15.46,-13.84,;15.46,-12.31,;16.78,-11.54,;18.11,-12.3,;21.95,-12.6,;21.94,-14.13,;27.43,-15.42,)| Show InChI InChI=1S/C28H37NO/c1-17(2)14-19-16-26(3)23-11-10-18-15-21-20-8-6-7-9-22(20)29-25(21)28(18,5)27(23,4)13-12-24(26)30-19/h6-9,14,18-19,23-24,29H,10-13,15-16H2,1-5H3/t18-,19-,23-,24-,26-,27-,28+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of LPI-mediated beta-arrestin recruitment after 90 mins by beta-gala... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
G-protein coupled receptor 55
(Homo sapiens (Human)) | BDBM50448074
(Emindole Sb)Show SMILES CC(C)=CCC[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C |r,wU:12.12,6.6,8.8,14.15,wD:17.18,28.33,6.5,(7.26,-25.92,;7.27,-24.39,;8.61,-23.64,;5.95,-23.62,;5.97,-22.09,;4.62,-21.3,;3.28,-22.08,;3.27,-20.55,;3.27,-23.63,;4.61,-24.41,;1.92,-24.4,;.59,-23.61,;.6,-22.07,;.59,-20.54,;1.94,-21.31,;1.95,-19.76,;.6,-18.98,;-.73,-19.75,;-2.2,-19.27,;-3.1,-20.54,;-2.21,-21.78,;-3.12,-23.02,;-4.58,-22.54,;-5.91,-23.31,;-7.23,-22.54,;-7.23,-21.01,;-5.91,-20.24,;-4.58,-21,;-.73,-21.3,;-.75,-22.83,)| Show InChI InChI=1S/C28H39NO/c1-18(2)9-8-15-26(3)23-13-12-19-17-21-20-10-6-7-11-22(20)29-25(21)28(19,5)27(23,4)16-14-24(26)30/h6-7,9-11,19,23-24,29-30H,8,12-17H2,1-5H3/t19-,23-,24-,26-,27-,28+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of LPI-mediated beta-arrestin recruitment after 90 mins by beta-gala... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
N-arachidonyl glycine receptor
(Homo sapiens (Human)) | BDBM50448073
(CHEMBL3120631)Show SMILES CC(C)=CCC[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O |r,wU:30.34,39.45,37.42,32.37,13.14,11.11,6.6,8.33,wD:35.40,16.17,27.32,6.5,(20.66,-6.65,;19.17,-6.25,;18.78,-4.76,;18.09,-7.35,;16.6,-6.94,;15.51,-8.04,;14.03,-7.64,;14.78,-6.3,;14,-9.19,;12.65,-9.94,;11.33,-9.15,;11.35,-7.61,;11.35,-6.07,;12.7,-6.86,;12.71,-5.32,;11.38,-4.53,;10.05,-5.29,;8.59,-4.81,;7.68,-6.06,;8.57,-7.31,;7.68,-8.55,;6.21,-8.08,;4.87,-8.86,;3.54,-8.09,;3.54,-6.54,;4.87,-5.77,;6.21,-6.53,;10.04,-6.84,;10.02,-8.37,;15.33,-9.98,;15.37,-11.51,;14.06,-12.32,;14.1,-13.84,;12.79,-14.65,;11.44,-13.92,;15.45,-14.58,;15.48,-16.11,;16.75,-13.78,;18.1,-14.51,;16.71,-12.24,;18.02,-11.44,)| Show InChI InChI=1S/C34H49NO6/c1-19(2)9-8-15-32(3)25-13-12-20-17-22-21-10-6-7-11-23(21)35-30(22)34(20,5)33(25,4)16-14-26(32)41-31-29(39)28(38)27(37)24(18-36)40-31/h6-7,9-11,20,24-29,31,35-39H,8,12-18H2,1-5H3/t20-,24+,25-,26-,27+,28-,29-,31-,32-,33-,34+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 10 uM THC-mediated beta-arrestin recruitment after 90 mins by bet... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
G-protein coupled receptor 55
(Homo sapiens (Human)) | BDBM50448073
(CHEMBL3120631)Show SMILES CC(C)=CCC[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O |r,wU:30.34,39.45,37.42,32.37,13.14,11.11,6.6,8.33,wD:35.40,16.17,27.32,6.5,(20.66,-6.65,;19.17,-6.25,;18.78,-4.76,;18.09,-7.35,;16.6,-6.94,;15.51,-8.04,;14.03,-7.64,;14.78,-6.3,;14,-9.19,;12.65,-9.94,;11.33,-9.15,;11.35,-7.61,;11.35,-6.07,;12.7,-6.86,;12.71,-5.32,;11.38,-4.53,;10.05,-5.29,;8.59,-4.81,;7.68,-6.06,;8.57,-7.31,;7.68,-8.55,;6.21,-8.08,;4.87,-8.86,;3.54,-8.09,;3.54,-6.54,;4.87,-5.77,;6.21,-6.53,;10.04,-6.84,;10.02,-8.37,;15.33,-9.98,;15.37,-11.51,;14.06,-12.32,;14.1,-13.84,;12.79,-14.65,;11.44,-13.92,;15.45,-14.58,;15.48,-16.11,;16.75,-13.78,;18.1,-14.51,;16.71,-12.24,;18.02,-11.44,)| Show InChI InChI=1S/C34H49NO6/c1-19(2)9-8-15-32(3)25-13-12-20-17-22-21-10-6-7-11-23(21)35-30(22)34(20,5)33(25,4)16-14-26(32)41-31-29(39)28(38)27(37)24(18-36)40-31/h6-7,9-11,20,24-29,31,35-39H,8,12-18H2,1-5H3/t20-,24+,25-,26-,27+,28-,29-,31-,32-,33-,34+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of LPI-mediated beta-arrestin recruitment after 90 mins by beta-gala... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
N-arachidonyl glycine receptor
(Homo sapiens (Human)) | BDBM50448074
(Emindole Sb)Show SMILES CC(C)=CCC[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C |r,wU:12.12,6.6,8.8,14.15,wD:17.18,28.33,6.5,(7.26,-25.92,;7.27,-24.39,;8.61,-23.64,;5.95,-23.62,;5.97,-22.09,;4.62,-21.3,;3.28,-22.08,;3.27,-20.55,;3.27,-23.63,;4.61,-24.41,;1.92,-24.4,;.59,-23.61,;.6,-22.07,;.59,-20.54,;1.94,-21.31,;1.95,-19.76,;.6,-18.98,;-.73,-19.75,;-2.2,-19.27,;-3.1,-20.54,;-2.21,-21.78,;-3.12,-23.02,;-4.58,-22.54,;-5.91,-23.31,;-7.23,-22.54,;-7.23,-21.01,;-5.91,-20.24,;-4.58,-21,;-.73,-21.3,;-.75,-22.83,)| Show InChI InChI=1S/C28H39NO/c1-18(2)9-8-15-26(3)23-13-12-19-17-21-20-10-6-7-11-22(20)29-25(21)28(19,5)27(23,4)16-14-24(26)30/h6-7,9-11,19,23-24,29-30H,8,12-17H2,1-5H3/t19-,23-,24-,26-,27-,28+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 10 uM THC-mediated beta-arrestin recruitment after 90 mins by bet... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
G-protein coupled receptor 55
(Homo sapiens (Human)) | BDBM50448076
(CHEMBL3120632)Show SMILES COC(C)(C)\C=C\C[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C |r| Show InChI InChI=1S/C29H41NO2/c1-26(2,32-6)15-9-16-27(3)23-13-12-19-18-21-20-10-7-8-11-22(20)30-25(21)29(19,5)28(23,4)17-14-24(27)31/h7-11,15,19,23-24,30-31H,12-14,16-18H2,1-6H3/b15-9+/t19-,23-,24-,27-,28-,29+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Antagonist activity at human GPR55 expressed in CHO cells assessed as inhibition of LPI-mediated beta-arrestin recruitment after 90 mins by beta-gala... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
N-arachidonyl glycine receptor
(Homo sapiens (Human)) | BDBM50448076
(CHEMBL3120632)Show SMILES COC(C)(C)\C=C\C[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1Cc3c([nH]c4ccccc34)[C@]21C |r| Show InChI InChI=1S/C29H41NO2/c1-26(2,32-6)15-9-16-27(3)23-13-12-19-18-21-20-10-7-8-11-22(20)30-25(21)29(19,5)28(23,4)17-14-24(27)31/h7-11,15,19,23-24,30-31H,12-14,16-18H2,1-6H3/b15-9+/t19-,23-,24-,27-,28-,29+/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description
Inverse agonist activity at human GPR18 expressed in CHO cells assessed as inhibition of 7.5 uM THC-mediated beta-arrestin recruitment after 90 mins ... |
J Nat Prod 77: 673-7 (2014)
Article DOI: 10.1021/np400850g
BindingDB Entry DOI: 10.7270/Q2154JJZ |
More data for this
Ligand-Target Pair | |
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