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PubMed code 24685543

Compile data set for download or QSAR
Found 23 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012102
PNG
(CHEMBL3263664)
Show SMILES Cc1ccoc1C(=O)Nc1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H37N5O4/c1-22-7-3-4-8-26(22)34-16-18-35(19-17-34)27-11-10-24(21-25(27)33-31(39)29-23(2)12-20-40-29)30(38)32-13-6-15-36-14-5-9-28(36)37/h3-4,7-8,10-12,20-21H,5-6,9,13-19H2,1-2H3,(H,32,38)(H,33,39)
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n/an/an/an/a 5.08E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012120
PNG
(CHEMBL3263691)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCc1nn[nH]n1
Show InChI InChI=1S/C29H33N9O3/c1-19-5-2-3-6-24(19)37-13-15-38(16-14-37)25-11-10-21(27(39)30-12-4-7-26-33-35-36-34-26)17-22(25)31-28(40)23-18-41-29(32-23)20-8-9-20/h2-3,5-6,10-11,17-18,20H,4,7-9,12-16H2,1H3,(H,30,39)(H,31,40)(H,33,34,35,36)
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n/an/an/an/a 8.90E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012101
PNG
(CHEMBL3263663)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H37N5O4/c1-22-7-3-4-8-26(22)34-17-19-35(20-18-34)27-12-11-24(21-25(27)33-31(39)28-13-10-23(2)40-28)30(38)32-14-6-16-36-15-5-9-29(36)37/h3-4,7-8,10-13,21H,5-6,9,14-20H2,1-2H3,(H,32,38)(H,33,39)
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n/an/an/an/a 1.29E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012111
PNG
(CHEMBL3263676)
Show SMILES Cc1cccc(c1)N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O4/c1-22-5-2-6-25(19-22)36-15-17-37(18-16-36)28-11-10-24(30(40)33-12-4-14-38-13-3-7-29(38)39)20-26(28)34-31(41)27-21-42-32(35-27)23-8-9-23/h2,5-6,10-11,19-21,23H,3-4,7-9,12-18H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 1.44E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012114
PNG
(CHEMBL3263685)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCc1cccc(c1)C(N)=O
Show InChI InChI=1S/C31H31N5O4/c1-21-6-2-3-9-26(21)35-13-15-36(16-14-35)27-12-11-24(19-25(27)34-31(39)28-10-5-17-40-28)30(38)33-20-22-7-4-8-23(18-22)29(32)37/h2-12,17-19H,13-16,20H2,1H3,(H2,32,37)(H,33,38)(H,34,39)
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n/an/an/an/a 4.60E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012121
PNG
(CHEMBL3263692)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)N[C@@H]1CCC[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C31H37N5O5/c1-19-5-2-3-7-25(19)35-13-15-36(16-14-35)26-12-11-21(29(39)32-22-6-4-8-27(37)28(22)38)17-23(26)33-30(40)24-18-41-31(34-24)20-9-10-20/h2-3,5,7,11-12,17-18,20,22,27-28,37-38H,4,6,8-10,13-16H2,1H3,(H,32,39)(H,33,40)/t22-,27-,28+/m1/s1
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n/an/an/an/a 5.30E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012117
PNG
(CHEMBL3263688)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCc1ccncc1
Show InChI InChI=1S/C33H36N6O3/c1-23-5-2-3-7-29(23)38-17-19-39(20-18-38)30-11-10-26(31(40)35-14-4-6-24-12-15-34-16-13-24)21-27(30)36-32(41)28-22-42-33(37-28)25-8-9-25/h2-3,5,7,10-13,15-16,21-22,25H,4,6,8-9,14,17-20H2,1H3,(H,35,40)(H,36,41)
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n/an/an/an/a 1.53E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012100
PNG
(CHEMBL3263661)
Show SMILES CN(C(=O)c1ccco1)c1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H37N5O4/c1-23-8-3-4-9-25(23)34-17-19-35(20-18-34)26-13-12-24(22-27(26)33(2)31(39)28-10-6-21-40-28)30(38)32-14-7-16-36-15-5-11-29(36)37/h3-4,6,8-10,12-13,21-22H,5,7,11,14-20H2,1-2H3,(H,32,38)
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n/an/an/an/a 8.82E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012109
PNG
(CHEMBL3263671)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccccn1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H36N6O3/c1-23-8-2-3-10-27(23)35-18-20-36(21-19-35)28-13-12-24(22-26(28)34-31(40)25-9-4-5-14-32-25)30(39)33-15-7-17-37-16-6-11-29(37)38/h2-5,8-10,12-14,22H,6-7,11,15-21H2,1H3,(H,33,39)(H,34,40)
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n/an/an/an/a 1.85E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012099
PNG
(CHEMBL3263660)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccoc1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C30H35N5O4/c1-22-6-2-3-7-26(22)33-15-17-34(18-16-33)27-10-9-23(20-25(27)32-30(38)24-11-19-39-21-24)29(37)31-12-5-14-35-13-4-8-28(35)36/h2-3,6-7,9-11,19-21H,4-5,8,12-18H2,1H3,(H,31,37)(H,32,38)
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n/an/an/an/a 4.94E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012106
PNG
(CHEMBL3263668)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1csc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O3S/c1-22-6-2-3-7-27(22)36-16-18-37(19-17-36)28-12-11-24(30(40)33-13-5-15-38-14-4-8-29(38)39)20-25(28)34-31(41)26-21-42-32(35-26)23-9-10-23/h2-3,6-7,11-12,20-21,23H,4-5,8-10,13-19H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 1.84E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012107
PNG
(CHEMBL3263669)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C29H37N5O3/c1-21-6-2-3-7-25(21)32-16-18-33(19-17-32)26-12-11-23(20-24(26)31-29(37)22-9-10-22)28(36)30-13-5-15-34-14-4-8-27(34)35/h2-3,6-7,11-12,20,22H,4-5,8-10,13-19H2,1H3,(H,30,36)(H,31,37)
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n/an/an/an/a 1.99E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012110
PNG
(CHEMBL3263674)
Show SMILES FC(F)(F)c1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H35F3N6O4/c33-32(34,35)23-5-1-2-6-26(23)39-15-17-40(18-16-39)27-11-10-22(29(43)36-12-4-14-41-13-3-7-28(41)42)19-24(27)37-30(44)25-20-45-31(38-25)21-8-9-21/h1-2,5-6,10-11,19-21H,3-4,7-9,12-18H2,(H,36,43)(H,37,44)
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n/an/an/an/a 1.00E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012112
PNG
(CHEMBL3263683)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCN1CCCC1=O
Show InChI InChI=1S/C29H33N5O4/c1-21-6-2-3-7-24(21)32-15-17-33(18-16-32)25-11-10-22(20-23(25)31-29(37)26-8-5-19-38-26)28(36)30-12-14-34-13-4-9-27(34)35/h2-3,5-8,10-11,19-20H,4,9,12-18H2,1H3,(H,30,36)(H,31,37)
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n/an/an/an/a 3.00E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012103
PNG
(CHEMBL3263665)
Show SMILES CN(C(=O)c1ccc[nH]1)c1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C31H38N6O3/c1-23-8-3-4-10-26(23)35-18-20-36(21-19-35)27-13-12-24(22-28(27)34(2)31(40)25-9-5-14-32-25)30(39)33-15-7-17-37-16-6-11-29(37)38/h3-5,8-10,12-14,22,32H,6-7,11,15-21H2,1-2H3,(H,33,39)
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n/an/an/an/a 4.90E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012104
PNG
(CHEMBL3263666)
Show SMILES Cc1nc(co1)C(=O)Nc1cc(ccc1N1CCN(CC1)c1ccccc1C)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C30H36N6O4/c1-21-7-3-4-8-26(21)34-15-17-35(18-16-34)27-11-10-23(19-24(27)33-30(39)25-20-40-22(2)32-25)29(38)31-12-6-14-36-13-5-9-28(36)37/h3-4,7-8,10-11,19-20H,5-6,9,12-18H2,1-2H3,(H,31,38)(H,33,39)
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n/an/an/an/a 2.50E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012105
PNG
(CHEMBL3263667)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1coc(n1)C1CC1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H38N6O4/c1-22-6-2-3-7-27(22)36-16-18-37(19-17-36)28-12-11-24(30(40)33-13-5-15-38-14-4-8-29(38)39)20-25(28)34-31(41)26-21-42-32(35-26)23-9-10-23/h2-3,6-7,11-12,20-21,23H,4-5,8-10,13-19H2,1H3,(H,33,40)(H,34,41)
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n/an/an/an/a 9.90E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012113
PNG
(CHEMBL3263684)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCN
Show InChI InChI=1S/C25H29N5O3/c1-18-5-2-3-6-21(18)29-12-14-30(15-13-29)22-9-8-19(24(31)27-11-10-26)17-20(22)28-25(32)23-7-4-16-33-23/h2-9,16-17H,10-15,26H2,1H3,(H,27,31)(H,28,32)
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n/an/an/an/a 1.85E+6n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012115
PNG
(CHEMBL3263686)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCC1CCCC1
Show InChI InChI=1S/C30H36N4O3/c1-22-7-2-5-10-26(22)33-16-18-34(19-17-33)27-13-12-24(29(35)31-15-14-23-8-3-4-9-23)21-25(27)32-30(36)28-11-6-20-37-28/h2,5-7,10-13,20-21,23H,3-4,8-9,14-19H2,1H3,(H,31,35)(H,32,36)
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n/an/an/an/a 1.29E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012119
PNG
(CHEMBL3263690)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCN1C(=O)CCC1=O
Show InChI InChI=1S/C30H33N5O5/c1-21-6-2-3-7-24(21)33-15-17-34(18-16-33)25-10-9-22(20-23(25)32-30(39)26-8-4-19-40-26)29(38)31-13-5-14-35-27(36)11-12-28(35)37/h2-4,6-10,19-20H,5,11-18H2,1H3,(H,31,38)(H,32,39)
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n/an/an/an/a 1.84E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012108
PNG
(CHEMBL3263670)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccccc1)C(=O)NCCCN1CCCC1=O
Show InChI InChI=1S/C32H37N5O3/c1-24-9-5-6-12-28(24)35-19-21-36(22-20-35)29-15-14-26(23-27(29)34-32(40)25-10-3-2-4-11-25)31(39)33-16-8-18-37-17-7-13-30(37)38/h2-6,9-12,14-15,23H,7-8,13,16-22H2,1H3,(H,33,39)(H,34,40)
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n/an/an/an/a 5.54E+5n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012118
PNG
(CHEMBL3263689)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCN1CCOC1=O
Show InChI InChI=1S/C29H33N5O5/c1-21-6-2-3-7-24(21)32-13-15-33(16-14-32)25-10-9-22(20-23(25)31-28(36)26-8-4-18-38-26)27(35)30-11-5-12-34-17-19-39-29(34)37/h2-4,6-10,18,20H,5,11-17,19H2,1H3,(H,30,35)(H,31,36)
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n/an/an/an/a 2.80E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
Follicle-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50012116
PNG
(CHEMBL3263687)
Show SMILES Cc1ccccc1N1CCN(CC1)c1ccc(cc1NC(=O)c1ccco1)C(=O)NCCCC1CCOC1
Show InChI InChI=1S/C30H36N4O4/c1-22-6-2-3-8-26(22)33-14-16-34(17-15-33)27-11-10-24(20-25(27)32-30(36)28-9-5-18-38-28)29(35)31-13-4-7-23-12-19-37-21-23/h2-3,5-6,8-11,18,20,23H,4,7,12-17,19,21H2,1H3,(H,31,35)(H,32,36)
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n/an/an/an/a 8.80E+4n/an/an/an/a



EMD Serono Research Institute

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF as...

Bioorg Med Chem Lett 24: 2168-72 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.018
BindingDB Entry DOI: 10.7270/Q2FB54GX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%