Found 11 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by FRET assay in presence of 30 uM ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 338 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Src catalytic domain in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 864 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Abl1 catalytic domain in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of human full length EphB4 expressed in MEF cells assessed as inhibition of human ephrin B2/FC chimera-stimulated receptor autophosphoryla... |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Lck catalytic domain in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50393034
(CHEMBL2152704)Show SMILES Cc1ccc(O)cc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(21.85,-7.48,;23.19,-8.25,;24.52,-7.48,;25.87,-8.25,;25.86,-9.8,;27.2,-10.57,;24.52,-10.56,;23.19,-9.78,;21.86,-10.55,;20.52,-9.78,;20.52,-8.25,;19.2,-7.49,;17.87,-8.26,;17.88,-9.78,;16.54,-10.55,;19.19,-10.54,;19.18,-12.07,;17.85,-12.85,;17.85,-14.39,;19.18,-15.15,;20.52,-14.39,;20.51,-12.85,;21.85,-12.09,;23.18,-12.87,)| Show InChI InChI=1S/C18H18N4O2/c1-10-6-7-11(23)8-14(10)22-17-15(16(19)20-9-21-17)12-4-2-3-5-13(12)18(22)24/h6-9,23H,2-5H2,1H3,(H2,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant EGFR catalytic domain in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393033
(CHEMBL2152699)Show InChI InChI=1S/C18H18N4O2/c1-24-12-6-4-5-11(9-12)22-17-15(16(19)20-10-21-17)13-7-2-3-8-14(13)18(22)23/h4-6,9-10H,2-3,7-8H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393035
(CHEMBL2152698)Show SMILES Cc1ccccc1-n1c2ncnc(N)c2c2CCCCc2c1=O |(-4.18,5.32,;-2.85,4.55,;-1.51,5.32,;-.17,4.55,;-.18,3,;-1.51,2.24,;-2.85,3.02,;-4.18,2.25,;-5.52,3.02,;-5.52,4.55,;-6.84,5.31,;-8.17,4.54,;-8.16,3.02,;-9.5,2.25,;-6.85,2.26,;-6.85,.73,;-8.18,-.05,;-8.18,-1.59,;-6.85,-2.35,;-5.52,-1.59,;-5.53,-.05,;-4.19,.71,;-2.86,-.07,)| Show InChI InChI=1S/C18H18N4O/c1-11-6-2-5-9-14(11)22-17-15(16(19)20-10-21-17)12-7-3-4-8-13(12)18(22)23/h2,5-6,9-10H,3-4,7-8H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393033
(CHEMBL2152699)Show InChI InChI=1S/C18H18N4O2/c1-24-12-6-4-5-11(9-12)22-17-15(16(19)20-10-21-17)13-7-2-3-8-14(13)18(22)23/h4-6,9-10H,2-3,7-8H2,1H3,(H2,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by FRET assay in presence of 30 uM ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50393036
(CHEMBL2152702)Show SMILES COc1cccc(c1)-n1c2ncnc(N)c2c2CC(C)(C)OCc2c1=O Show InChI InChI=1S/C19H20N4O3/c1-19(2)8-13-14(9-26-19)18(24)23(11-5-4-6-12(7-11)25-3)17-15(13)16(20)21-10-22-17/h4-7,10H,8-9H2,1-3H3,(H2,20,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 in presence of 1 uM radiolabeled ATP |
ACS Med Chem Lett 3: 834-838 (2012)
Article DOI: 10.1021/ml3001984
BindingDB Entry DOI: 10.7270/Q28S4R0N |
More data for this
Ligand-Target Pair | |
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