Found 3 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
DNA polymerase alpha catalytic subunit
(Homo sapiens (Human)) | BDBM50021053
(CHEMBL3287609)Show SMILES C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1c1ccc2c(N)ncnn12 |r| Show InChI InChI=1S/C12H19N4O13P3/c1-12(18)9(17)8(4-26-31(22,23)29-32(24,25)28-30(19,20)21)27-10(12)6-2-3-7-11(13)14-5-15-16(6)7/h2-3,5,8-10,17-18H,4H2,1H3,(H,22,23)(H,24,25)(H2,13,14,15)(H2,19,20,21)/t8-,9-,10+,12-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Biota Scientific Management Pty. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human DNA polymerase alpha |
ACS Med Chem Lett 5: 679-84 (2014)
Article DOI: 10.1021/ml500077j BindingDB Entry DOI: 10.7270/Q2B56MBN |
More data for this Ligand-Target Pair | |
DNA polymerase beta
(Homo sapiens (Human)) | BDBM50021053
(CHEMBL3287609)Show SMILES C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1c1ccc2c(N)ncnn12 |r| Show InChI InChI=1S/C12H19N4O13P3/c1-12(18)9(17)8(4-26-31(22,23)29-32(24,25)28-30(19,20)21)27-10(12)6-2-3-7-11(13)14-5-15-16(6)7/h2-3,5,8-10,17-18H,4H2,1H3,(H,22,23)(H,24,25)(H2,13,14,15)(H2,19,20,21)/t8-,9-,10+,12-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Biota Scientific Management Pty. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human DNA polymerase beta |
ACS Med Chem Lett 5: 679-84 (2014)
Article DOI: 10.1021/ml500077j BindingDB Entry DOI: 10.7270/Q2B56MBN |
More data for this Ligand-Target Pair | |
DNA polymerase subunit gamma-1
(Homo sapiens (Human)) | BDBM50021053
(CHEMBL3287609)Show SMILES C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1c1ccc2c(N)ncnn12 |r| Show InChI InChI=1S/C12H19N4O13P3/c1-12(18)9(17)8(4-26-31(22,23)29-32(24,25)28-30(19,20)21)27-10(12)6-2-3-7-11(13)14-5-15-16(6)7/h2-3,5,8-10,17-18H,4H2,1H3,(H,22,23)(H,24,25)(H2,13,14,15)(H2,19,20,21)/t8-,9-,10+,12-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Biota Scientific Management Pty. Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human DNA polymerase gamma |
ACS Med Chem Lett 5: 679-84 (2014)
Article DOI: 10.1021/ml500077j BindingDB Entry DOI: 10.7270/Q2B56MBN |
More data for this Ligand-Target Pair | |