Affinity Data by PubMed id=25224652

PubMed code 25224652

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Eukaryotic elongation factor 2 kinase (Homo sapiens (Human))	BDBM123834 (4-(3-methoxyphenyl)-2,6-dioxo-3,5-piperidinedicarb...) Show SMILES COc1cccc(c1)C1C(C#N)C(=O)NC(=O)C1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin					Assay Description WT eEF-2K (2 nM) was preincubated with various concentrations of inhibitors (0-1000 uM) in assay buffer containing CaCl2 (150 uM), calmodulin (1 uM),...				Chembiochem 15: 2435-42 (2014) Article DOI: 10.1002/cbic.201402321 BindingDB Entry DOI: 10.7270/Q2MK6BJN
The University of Texas at Austin					More data for this Ligand-Target Pair
Eukaryotic elongation factor 2 kinase (Homo sapiens (Human))	BDBM123836 (4-(3,4-dichlorophenyl)-2,6-dioxopiperidine-3,5-dic...) Show SMILES Clc1ccc(cc1Cl)C1C(C#N)C(=O)NC(=O)C1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin					Assay Description WT eEF-2K (2 nM) was preincubated with various concentrations of inhibitors (0-1000 uM) in assay buffer containing CaCl2 (150 uM), calmodulin (1 uM),...				Chembiochem 15: 2435-42 (2014) Article DOI: 10.1002/cbic.201402321 BindingDB Entry DOI: 10.7270/Q2MK6BJN
The University of Texas at Austin					More data for this Ligand-Target Pair
Eukaryotic elongation factor 2 kinase (Homo sapiens (Human))	BDBM123835 (4‐(2‐methylphenyl)‐2,6‐dio...) Show SMILES Cc1ccccc1C1C(C#N)C(=O)NC(=O)C1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin					Assay Description WT eEF-2K (2 nM) was preincubated with various concentrations of inhibitors (0-1000 uM) in assay buffer containing CaCl2 (150 uM), calmodulin (1 uM),...				Chembiochem 15: 2435-42 (2014) Article DOI: 10.1002/cbic.201402321 BindingDB Entry DOI: 10.7270/Q2MK6BJN
The University of Texas at Austin					More data for this Ligand-Target Pair
Eukaryotic elongation factor 2 kinase (Homo sapiens (Human))	BDBM123837 (4‐(4‐methylphenyl)‐2,6‐dio...) Show SMILES Cc1ccc(cc1)C1C(C#N)C(=O)NC(=O)C1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin					Assay Description WT eEF-2K (2 nM) was preincubated with various concentrations of inhibitors (0-1000 uM) in assay buffer containing CaCl2 (150 uM), calmodulin (1 uM),...				Chembiochem 15: 2435-42 (2014) Article DOI: 10.1002/cbic.201402321 BindingDB Entry DOI: 10.7270/Q2MK6BJN
The University of Texas at Austin					More data for this Ligand-Target Pair
Eukaryotic elongation factor 2 kinase (Homo sapiens (Human))	BDBM123839 (4‐(2,6‐dichlorophenyl)‐2,6‐...) Show SMILES Clc1cccc(Cl)c1C1C(C#N)C(=O)NC(=O)C1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin					Assay Description WT eEF-2K (2 nM) was preincubated with various concentrations of inhibitors (0-1000 uM) in assay buffer containing CaCl2 (150 uM), calmodulin (1 uM),...				Chembiochem 15: 2435-42 (2014) Article DOI: 10.1002/cbic.201402321 BindingDB Entry DOI: 10.7270/Q2MK6BJN
The University of Texas at Austin					More data for this Ligand-Target Pair
Eukaryotic elongation factor 2 kinase (Homo sapiens (Human))	BDBM123838 (4‐(3‐hydroxyphenyl)‐2,6‐di...) Show SMILES Oc1cccc(c1)C1C(C#N)C(=O)NC(=O)C1C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin					Assay Description WT eEF-2K (2 nM) was preincubated with various concentrations of inhibitors (0-1000 uM) in assay buffer containing CaCl2 (150 uM), calmodulin (1 uM),...				Chembiochem 15: 2435-42 (2014) Article DOI: 10.1002/cbic.201402321 BindingDB Entry DOI: 10.7270/Q2MK6BJN
The University of Texas at Austin					More data for this Ligand-Target Pair

* indicates data uncertainty>20%