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PubMed code 25380412

Compile data set for download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032334
PNG
(CHEMBL3353541)
Show SMILES C[C@@]1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1 |r|
Show InChI InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032340
PNG
(CHEMBL3353514)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1
Show InChI InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)
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n/an/a 25n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032437
PNG
(CHEMBL3353533)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2ccoc2c1
Show InChI InChI=1S/C28H28N2O5S/c1-28(11-13-30(28)25(31)16-21-18-36-24-6-3-2-5-22(21)24)27(34)29(12-4-7-26(32)33)17-19-8-9-20-10-14-35-23(20)15-19/h2-3,5-6,8-10,14-15,18H,4,7,11-13,16-17H2,1H3,(H,32,33)
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n/an/a 36n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032302
PNG
(CHEMBL3353483)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CC(O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O4S/c1-24(23(31)26(14-22(29)30)13-16-6-8-18(25)9-7-16)10-11-27(24)21(28)12-17-15-32-20-5-3-2-4-19(17)20/h2-9,15H,10-14H2,1H3,(H,29,30)
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n/an/a 36n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032438
PNG
(CHEMBL3353534)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2cn[nH]c2c1
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n/an/a 40n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032300
PNG
(CHEMBL3353485)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O4S/c1-26(12-14-29(26)23(30)15-19-17-34-22-6-3-2-5-21(19)22)25(33)28(13-4-7-24(31)32)16-18-8-10-20(27)11-9-18/h2-3,5-6,8-11,17H,4,7,12-16H2,1H3,(H,31,32)
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n/an/a 42n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032305
PNG
(CHEMBL3353480)
Show SMILES CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12
Show InChI InChI=1S/C26H30ClN3O4S2/c1-26(12-14-30(26)24(31)16-20-18-35-23-7-4-3-6-22(20)23)25(32)29(13-5-15-36(33,34)28-2)17-19-8-10-21(27)11-9-19/h3-4,6-11,18,28H,5,12-17H2,1-2H3
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n/an/a 44n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032378
PNG
(CHEMBL3353532)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2cc[nH]c2c1
Show InChI InChI=1S/C28H29N3O4S/c1-28(11-14-31(28)25(32)16-21-18-36-24-6-3-2-5-22(21)24)27(35)30(13-4-7-26(33)34)17-19-8-9-20-10-12-29-23(20)15-19/h2-3,5-6,8-10,12,15,18,29H,4,7,11,13-14,16-17H2,1H3,(H,33,34)
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n/an/a 48n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032375
PNG
(CHEMBL3353530)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N2O4S/c1-26(12-14-32(26)23(33)15-19-17-37-22-6-3-2-5-21(19)22)25(36)31(13-4-7-24(34)35)16-18-8-10-20(11-9-18)27(28,29)30/h2-3,5-6,8-11,17H,4,7,12-16H2,1H3,(H,34,35)
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n/an/a 57n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032337
PNG
(CHEMBL3353511)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H23ClN2O4S/c1-24(12-14-27(24)22(30)19-15-32-20-6-3-2-5-18(19)20)23(31)26(13-4-7-21(28)29)17-10-8-16(25)9-11-17/h2-3,5-6,8-11,15H,4,7,12-14H2,1H3,(H,28,29)
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n/an/a 63n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032341
PNG
(CHEMBL3353515)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2cc[nH]c2c1
Show InChI InChI=1S/C27H27N3O4S/c1-27(11-14-30(27)25(33)21-17-35-23-6-3-2-5-20(21)23)26(34)29(13-4-7-24(31)32)16-18-8-9-19-10-12-28-22(19)15-18/h2-3,5-6,8-10,12,15,17,28H,4,7,11,13-14,16H2,1H3,(H,31,32)
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n/an/a 63n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032326
PNG
(CHEMBL3353475)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(=O)N1CCOCC1)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C30H34ClN3O4S/c1-30(12-14-34(30)28(36)19-23-21-39-26-6-3-2-5-25(23)26)29(37)33(20-22-8-10-24(31)11-9-22)13-4-7-27(35)32-15-17-38-18-16-32/h2-3,5-6,8-11,21H,4,7,12-20H2,1H3
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n/an/a 76n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032330
PNG
(CHEMBL3353479)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCS(N)(=O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H28ClN3O4S2/c1-25(11-13-29(25)23(30)15-19-17-34-22-6-3-2-5-21(19)22)24(31)28(12-4-14-35(27,32)33)16-18-7-9-20(26)10-8-18/h2-3,5-10,17H,4,11-16H2,1H3,(H2,27,32,33)
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n/an/a 76n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032370
PNG
(CHEMBL3353526)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2ccc3cc[nH]c3c2)c1
Show InChI InChI=1S/C28H33N3O4/c1-19-13-20(2)15-22(14-19)17-25(32)31-12-9-28(31,3)27(35)30(11-4-5-26(33)34)18-21-6-7-23-8-10-29-24(23)16-21/h6-8,10,13-16,29H,4-5,9,11-12,17-18H2,1-3H3,(H,33,34)
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n/an/a 85n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032442
PNG
(CHEMBL3353538)
Show SMILES CC1(CCN1C(=O)Cc1coc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2cc[nH]c2c1
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n/an/a 90n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032439
PNG
(CHEMBL3353535)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2scnc2c1
Show InChI InChI=1S/C27H27N3O4S2/c1-27(10-12-30(27)24(31)14-19-16-35-22-6-3-2-5-20(19)22)26(34)29(11-4-7-25(32)33)15-18-8-9-23-21(13-18)28-17-36-23/h2-3,5-6,8-9,13,16-17H,4,7,10-12,14-15H2,1H3,(H,32,33)
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n/an/a 95n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032342
PNG
(CHEMBL3353516)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2ccoc2c1
Show InChI InChI=1S/C27H26N2O5S/c1-27(11-13-29(27)25(32)21-17-35-23-6-3-2-5-20(21)23)26(33)28(12-4-7-24(30)31)16-18-8-9-19-10-14-34-22(19)15-18/h2-3,5-6,8-10,14-15,17H,4,7,11-13,16H2,1H3,(H,30,31)
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n/an/a 115n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032443
PNG
(CHEMBL3353539)
Show SMILES CC1(CCN1C(=O)Cc1coc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2ccoc2c1
Show InChI InChI=1S/C28H28N2O6/c1-28(11-13-30(28)25(31)16-21-18-36-23-6-3-2-5-22(21)23)27(34)29(12-4-7-26(32)33)17-19-8-9-20-10-14-35-24(20)15-19/h2-3,5-6,8-10,14-15,18H,4,7,11-13,16-17H2,1H3,(H,32,33)
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n/an/a 116n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032279
PNG
(CHEMBL3353502)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H25ClN2O4S/c1-25(12-14-28(25)23(31)20-16-33-21-6-3-2-5-19(20)21)24(32)27(13-4-7-22(29)30)15-17-8-10-18(26)11-9-17/h2-3,5-6,8-11,16H,4,7,12-15H2,1H3,(H,29,30)
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n/an/a 118n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032319
PNG
(CHEMBL3353468)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(N)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H28ClN3O3/c1-16-10-17(2)12-19(11-16)13-22(30)28-9-8-24(28,3)23(31)27(15-21(26)29)14-18-4-6-20(25)7-5-18/h4-7,10-12H,8-9,13-15H2,1-3H3,(H2,26,29)
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n/an/a 123n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032343
PNG
(CHEMBL3353517)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2cn[nH]c2c1
Show InChI InChI=1S/C26H26N4O4S/c1-26(10-12-30(26)24(33)20-16-35-22-6-3-2-5-19(20)22)25(34)29(11-4-7-23(31)32)15-17-8-9-18-14-27-28-21(18)13-17/h2-3,5-6,8-9,13-14,16H,4,7,10-12,15H2,1H3,(H,27,28)(H,31,32)
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n/an/a 130n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032444
PNG
(CHEMBL3353540)
Show SMILES CC1(CCN1C(=O)Cc1coc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2cn[nH]c2c1
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n/an/a 138n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032285
PNG
(CHEMBL3353498)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12
Show InChI InChI=1S/C22H21ClN2O2S/c1-22(21(27)24(2)13-15-7-9-16(23)10-8-15)11-12-25(22)20(26)18-14-28-19-6-4-3-5-17(18)19/h3-10,14H,11-13H2,1-2H3
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032317
PNG
(CHEMBL3353466)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC#N)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN3O2S/c1-26(25(32)29(14-5-4-13-28)17-19-8-10-21(27)11-9-19)12-15-30(26)24(31)16-20-18-33-23-7-3-2-6-22(20)23/h2-3,6-11,18H,4-5,12,14-17H2,1H3
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n/an/a 143n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032373
PNG
(CHEMBL3353528)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2ccc3cn[nH]c3c2)c1
Show InChI InChI=1S/C27H32N4O4/c1-18-11-19(2)13-21(12-18)15-24(32)31-10-8-27(31,3)26(35)30(9-4-5-25(33)34)17-20-6-7-22-16-28-29-23(22)14-20/h6-7,11-14,16H,4-5,8-10,15,17H2,1-3H3,(H,28,29)(H,33,34)
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032322
PNG
(CHEMBL3353471)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(N)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C26H32ClN3O3/c1-18-13-19(2)15-21(14-18)16-24(32)30-12-10-26(30,3)25(33)29(11-4-5-23(28)31)17-20-6-8-22(27)9-7-20/h6-9,13-15H,4-5,10-12,16-17H2,1-3H3,(H2,28,31)
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n/an/a 158n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032278
PNG
(CHEMBL3353503)
Show SMILES CC1(CCN1C(=O)CC1=COC2C=CC=CC12)C(=O)N(CCCC(O)=O)Cc1ccc(Cl)cc1 |c:13,15,t:9|
Show InChI InChI=1S/C26H29ClN2O5/c1-26(12-14-29(26)23(30)15-19-17-34-22-6-3-2-5-21(19)22)25(33)28(13-4-7-24(31)32)16-18-8-10-20(27)11-9-18/h2-3,5-6,8-11,17,21-22H,4,7,12-16H2,1H3,(H,31,32)
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n/an/a 166n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032349
PNG
(CHEMBL3353523)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C26H31ClN2O4/c1-18-13-19(2)15-21(14-18)16-23(30)29-12-10-26(29,3)25(33)28(11-4-5-24(31)32)17-20-6-8-22(27)9-7-20/h6-9,13-15H,4-5,10-12,16-17H2,1-3H3,(H,31,32)
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n/an/a 179n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032277
PNG
(CHEMBL3353504)
Show SMILES CC1(CCN1C(=O)CC1=COC2C=CC=CC12)C(=O)N(CC(O)=O)Cc1ccc(Cl)cc1 |c:13,15,t:9|
Show InChI InChI=1S/C24H25ClN2O5/c1-24(23(31)26(14-22(29)30)13-16-6-8-18(25)9-7-16)10-11-27(24)21(28)12-17-15-32-20-5-3-2-4-19(17)20/h2-9,15,19-20H,10-14H2,1H3,(H,29,30)
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032329
PNG
(CHEMBL3353478)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCS(N)(=O)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C25H32ClN3O4S/c1-18-13-19(2)15-21(14-18)16-23(30)29-11-9-25(29,3)24(31)28(10-4-12-34(27,32)33)17-20-5-7-22(26)8-6-20/h5-8,13-15H,4,9-12,16-17H2,1-3H3,(H2,27,32,33)
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n/an/a 245n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032316
PNG
(CHEMBL3353465)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CC#N)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C24H22ClN3O2S/c1-24(23(30)27(13-11-26)15-17-6-8-19(25)9-7-17)10-12-28(24)22(29)14-18-16-31-21-5-3-2-4-20(18)21/h2-9,16H,10,12-15H2,1H3
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n/an/a 247n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032339
PNG
(CHEMBL3353513)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H25F3N2O4S/c1-25(12-14-31(25)23(34)20-16-36-21-6-3-2-5-19(20)21)24(35)30(13-4-7-22(32)33)15-17-8-10-18(11-9-17)26(27,28)29/h2-3,5-6,8-11,16H,4,7,12-15H2,1H3,(H,32,33)
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n/an/a 256n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032440
PNG
(CHEMBL3353536)
Show SMILES CC1(CCN1C(=O)Cc1coc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N2O5/c1-26(12-14-32(26)23(33)15-19-17-37-22-6-3-2-5-21(19)22)25(36)31(13-4-7-24(34)35)16-18-8-10-20(11-9-18)27(28,29)30/h2-3,5-6,8-11,17H,4,7,12-16H2,1H3,(H,34,35)
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n/an/a 261n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032304
PNG
(CHEMBL3353481)
Show SMILES CNS(=O)(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C26H34ClN3O4S/c1-19-14-20(2)16-22(15-19)17-24(31)30-12-10-26(30,3)25(32)29(11-5-13-35(33,34)28-4)18-21-6-8-23(27)9-7-21/h6-9,14-16,28H,5,10-13,17-18H2,1-4H3
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n/an/a 263n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032309
PNG
(CHEMBL3353001)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12
Show InChI InChI=1S/C23H23ClN2O2S/c1-23(22(28)25(2)14-16-7-9-18(24)10-8-16)11-12-26(23)21(27)13-17-15-29-20-6-4-3-5-19(17)20/h3-10,15H,11-14H2,1-2H3
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032303
PNG
(CHEMBL3353482)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(O)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H27ClN2O4/c1-16-10-17(2)12-19(11-16)13-21(28)27-9-8-24(27,3)23(31)26(15-22(29)30)14-18-4-6-20(25)7-5-18/h4-7,10-12H,8-9,13-15H2,1-3H3,(H,29,30)
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032301
PNG
(CHEMBL3353484)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCC(O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C25H25ClN2O4S/c1-25(24(32)27(12-10-23(30)31)15-17-6-8-19(26)9-7-17)11-13-28(25)22(29)14-18-16-33-21-5-3-2-4-20(18)21/h2-9,16H,10-15H2,1H3,(H,30,31)
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032344
PNG
(CHEMBL3353518)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1ccc2scnc2c1
Show InChI InChI=1S/C26H25N3O4S2/c1-26(10-12-29(26)24(32)19-15-34-21-6-3-2-5-18(19)21)25(33)28(11-4-7-23(30)31)14-17-8-9-22-20(13-17)27-16-35-22/h2-3,5-6,8-9,13,15-16H,4,7,10-12,14H2,1H3,(H,30,31)
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032327
PNG
(CHEMBL3353476)
Show SMILES CC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1csc2ccccc12
Show InChI InChI=1S/C26H28ClN3O3S/c1-18(31)28-12-14-29(16-19-7-9-21(27)10-8-19)25(33)26(2)11-13-30(26)24(32)15-20-17-34-23-6-4-3-5-22(20)23/h3-10,17H,11-16H2,1-2H3,(H,28,31)
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032338
PNG
(CHEMBL3353512)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)c1cccc(Cl)c1
Show InChI InChI=1S/C24H23ClN2O4S/c1-24(11-13-27(24)22(30)19-15-32-20-9-3-2-8-18(19)20)23(31)26(12-5-10-21(28)29)17-7-4-6-16(25)14-17/h2-4,6-9,14-15H,5,10-13H2,1H3,(H,28,29)
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n/an/a 347n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032318
PNG
(CHEMBL3353467)
Show SMILES COC(=O)CCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C27H33ClN2O4/c1-19-14-20(2)16-22(15-19)17-24(31)30-13-11-27(30,3)26(33)29(12-5-6-25(32)34-4)18-21-7-9-23(28)10-8-21/h7-10,14-16H,5-6,11-13,17-18H2,1-4H3
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n/an/a 361n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032325
PNG
(CHEMBL3353474)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C30H38ClN3O4/c1-22-17-23(2)19-25(18-22)20-28(36)34-12-10-30(34,3)29(37)33(21-24-6-8-26(31)9-7-24)11-4-5-27(35)32-13-15-38-16-14-32/h6-9,17-19H,4-5,10-16,20-21H2,1-3H3
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n/an/a 388n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032328
PNG
(CHEMBL3353477)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCNS(C)(=O)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C25H32ClN3O4S/c1-18-13-19(2)15-21(14-18)16-23(30)29-11-9-25(29,3)24(31)28(12-10-27-34(4,32)33)17-20-5-7-22(26)8-6-20/h5-8,13-15,27H,9-12,16-17H2,1-4H3
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n/an/a 429n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032320
PNG
(CHEMBL3353469)
Show SMILES CNC(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C25H30ClN3O3/c1-17-11-18(2)13-20(12-17)14-23(31)29-10-9-25(29,3)24(32)28(16-22(30)27-4)15-19-5-7-21(26)8-6-19/h5-8,11-13H,9-10,14-16H2,1-4H3,(H,27,30)
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n/an/a 442n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032310
PNG
(CHEMBL3353002)
Show SMILES CCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C24H29ClN2O2/c1-5-26(16-19-6-8-21(25)9-7-19)23(29)24(4)10-11-27(24)22(28)15-20-13-17(2)12-18(3)14-20/h6-9,12-14H,5,10-11,15-16H2,1-4H3
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n/an/a 473n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032334
PNG
(CHEMBL3353541)
Show SMILES C[C@@]1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1 |r|
Show InChI InChI=1S/C25H25ClN2O4S/c1-25(11-13-28(25)23(31)20-16-33-21-9-3-2-8-19(20)21)24(32)27(12-5-10-22(29)30)15-17-6-4-7-18(26)14-17/h2-4,6-9,14,16H,5,10-13,15H2,1H3,(H,29,30)/t25-/m1/s1
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n/an/a 483n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against FFA2 receptor in human whole blood assessed as inhibition of sodium acetate-induced CD11b[AE] expression by flow cytometr...

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032377
PNG
(CHEMBL3353531)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1
Show InChI InChI=1S/C26H27ClN2O4S/c1-26(11-13-29(26)23(30)15-19-17-34-22-9-3-2-8-21(19)22)25(33)28(12-5-10-24(31)32)16-18-6-4-7-20(27)14-18/h2-4,6-9,14,17H,5,10-13,15-16H2,1H3,(H,31,32)
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n/an/a 500n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032323
PNG
(CHEMBL3353472)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCC(N)=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C25H30ClN3O3/c1-17-12-18(2)14-20(13-17)15-23(31)29-11-9-25(29,3)24(32)28(10-8-22(27)30)16-19-4-6-21(26)7-5-19/h4-7,12-14H,8-11,15-16H2,1-3H3,(H2,27,30)
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n/an/a 510n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032350
PNG
(CHEMBL3353524)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2ccc(cc2)C(F)(F)F)c1
Show InChI InChI=1S/C27H31F3N2O4/c1-18-13-19(2)15-21(14-18)16-23(33)32-12-10-26(32,3)25(36)31(11-4-5-24(34)35)17-20-6-8-22(9-7-20)27(28,29)30/h6-9,13-15H,4-5,10-12,16-17H2,1-3H3,(H,34,35)
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n/an/a 551n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032346
PNG
(CHEMBL3353520)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)c1cc(Cl)ccn1
Show InChI InChI=1S/C23H22ClN3O4S/c1-23(9-12-27(23)21(30)17-14-32-18-6-3-2-5-16(17)18)22(31)26(11-4-7-20(28)29)19-13-15(24)8-10-25-19/h2-3,5-6,8,10,13-14H,4,7,9,11-12H2,1H3,(H,28,29)
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n/an/a 579n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032347
PNG
(CHEMBL3353521)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)c1ccc(Cl)cn1
Show InChI InChI=1S/C23H22ClN3O4S/c1-23(10-12-27(23)21(30)17-14-32-18-6-3-2-5-16(17)18)22(31)26(11-4-7-20(28)29)19-9-8-15(24)13-25-19/h2-3,5-6,8-9,13-14H,4,7,10-12H2,1H3,(H,28,29)
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n/an/a 663n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032374
PNG
(CHEMBL3353529)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2ccc3scnc3c2)c1
Show InChI InChI=1S/C27H31N3O4S/c1-18-11-19(2)13-21(12-18)15-24(31)30-10-8-27(30,3)26(34)29(9-4-5-25(32)33)16-20-6-7-23-22(14-20)28-17-35-23/h6-7,11-14,17H,4-5,8-10,15-16H2,1-3H3,(H,32,33)
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n/an/a 711n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032372
PNG
(CHEMBL3353527)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2ccc3ccoc3c2)c1
Show InChI InChI=1S/C28H32N2O5/c1-19-13-20(2)15-22(14-19)17-25(31)30-11-9-28(30,3)27(34)29(10-4-5-26(32)33)18-21-6-7-23-8-12-35-24(23)16-21/h6-8,12-16H,4-5,9-11,17-18H2,1-3H3,(H,32,33)
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n/an/a 781n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032336
PNG
(CHEMBL3353510)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)CCc1ccc(Cl)cc1
Show InChI InChI=1S/C26H27ClN2O4S/c1-26(13-16-29(26)24(32)21-17-34-22-6-3-2-5-20(21)22)25(33)28(14-4-7-23(30)31)15-12-18-8-10-19(27)11-9-18/h2-3,5-6,8-11,17H,4,7,12-16H2,1H3,(H,30,31)
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n/an/a 1.14E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032314
PNG
(CHEMBL3353464)
Show SMILES COCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C25H31ClN2O3/c1-18-13-19(2)15-21(14-18)16-23(29)28-10-9-25(28,3)24(30)27(11-12-31-4)17-20-5-7-22(26)8-6-20/h5-8,13-15H,9-12,16-17H2,1-4H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032308
PNG
(CHEMBL3353000)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C23H27ClN2O2/c1-16-11-17(2)13-19(12-16)14-21(27)26-10-9-23(26,3)22(28)25(4)15-18-5-7-20(24)8-6-18/h5-8,11-13H,9-10,14-15H2,1-4H3
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n/an/a 1.43E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032306
PNG
(CHEMBL3352998)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN2O2S/c1-22(21(27)24-13-15-6-8-17(23)9-7-15)10-11-25(22)20(26)12-16-14-28-19-5-3-2-4-18(16)19/h2-9,14H,10-13H2,1H3,(H,24,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032321
PNG
(CHEMBL3353470)
Show SMILES CN(C)C(=O)CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C26H32ClN3O3/c1-18-12-19(2)14-21(13-18)15-23(31)30-11-10-26(30,3)25(33)29(17-24(32)28(4)5)16-20-6-8-22(27)9-7-20/h6-9,12-14H,10-11,15-17H2,1-5H3
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n/an/a 1.58E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032348
PNG
(CHEMBL3353522)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)c1ccc(Cl)nc1
Show InChI InChI=1S/C23H22ClN3O4S/c1-23(10-12-27(23)21(30)17-14-32-18-6-3-2-5-16(17)18)22(31)26(11-4-7-20(28)29)15-8-9-19(24)25-13-15/h2-3,5-6,8-9,13-14H,4,7,10-12H2,1H3,(H,28,29)
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n/an/a 2.85E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032294
PNG
(CHEMBL3353491)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H23ClN2O2/c1-24(23(29)26(2)16-17-10-12-19(25)13-11-17)14-15-27(24)22(28)21-9-5-7-18-6-3-4-8-20(18)21/h3-13H,14-16H2,1-2H3
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n/an/a 3.35E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032311
PNG
(CHEMBL3353003)
Show SMILES CC1(CCN1C(=O)Cc1csc2ccccc12)C(=O)N(CCO)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C24H25ClN2O3S/c1-24(23(30)26(12-13-28)15-17-6-8-19(25)9-7-17)10-11-27(24)22(29)14-18-16-31-21-5-3-2-4-20(18)21/h2-9,16,28H,10-15H2,1H3
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n/an/a 3.35E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032369
PNG
(CHEMBL3353525)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCCC(O)=O)Cc2cccc(Cl)c2)c1
Show InChI InChI=1S/C26H31ClN2O4/c1-18-12-19(2)14-21(13-18)16-23(30)29-11-9-26(29,3)25(33)28(10-5-8-24(31)32)17-20-6-4-7-22(27)15-20/h4,6-7,12-15H,5,8-11,16-17H2,1-3H3,(H,31,32)
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n/an/a 3.35E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032284
PNG
(CHEMBL3353499)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1csc2ccc(Cl)cc12
Show InChI InChI=1S/C22H20Cl2N2O2S/c1-22(21(28)25(2)12-14-3-5-15(23)6-4-14)9-10-26(22)20(27)18-13-29-19-8-7-16(24)11-17(18)19/h3-8,11,13H,9-10,12H2,1-2H3
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n/an/a 3.35E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032293
PNG
(CHEMBL3352828)
Show SMILES COc1c(Cl)scc1C(=O)N1CCC1(C)C(=O)N(C)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-19(18(25)22(2)10-12-4-6-13(20)7-5-12)8-9-23(19)17(24)14-11-27-16(21)15(14)26-3/h4-7,11H,8-10H2,1-3H3
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n/an/a 3.35E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032292
PNG
(CHEMBL3353492)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cn(C)c2ccccc12
Show InChI InChI=1S/C24H26ClN3O2/c1-24(23(30)27(3)15-17-8-10-19(25)11-9-17)12-13-28(24)22(29)14-18-16-26(2)21-7-5-4-6-20(18)21/h4-11,16H,12-15H2,1-3H3
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n/an/a 4.47E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032324
PNG
(CHEMBL3353473)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CC(=O)N2CCOCC2)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C28H34ClN3O4/c1-20-14-21(2)16-23(15-20)17-25(33)32-9-8-28(32,3)27(35)31(18-22-4-6-24(29)7-5-22)19-26(34)30-10-12-36-13-11-30/h4-7,14-16H,8-13,17-19H2,1-3H3
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n/an/a 4.67E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032283
PNG
(CHEMBL3353500)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc2ccccc2s1
Show InChI InChI=1S/C23H23ClN2O2S/c1-23(22(28)25(2)15-16-7-9-18(24)10-8-16)11-12-26(23)21(27)14-19-13-17-5-3-4-6-20(17)29-19/h3-10,13H,11-12,14-15H2,1-2H3
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n/an/a 5.00E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032276
PNG
(CHEMBL3353505)
Show SMILES CC1(CCN1C(=O)Cc1noc2ccccc12)C(=O)N(CC(O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C23H22ClN3O5/c1-23(22(31)26(14-21(29)30)13-15-6-8-16(24)9-7-15)10-11-27(23)20(28)12-18-17-4-2-3-5-19(17)32-25-18/h2-9H,10-14H2,1H3,(H,29,30)
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n/an/a 5.01E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032289
PNG
(CHEMBL3353495)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1ccc2occc2c1
Show InChI InChI=1S/C22H21ClN2O3/c1-22(21(27)24(2)14-15-3-6-18(23)7-4-15)10-11-25(22)20(26)17-5-8-19-16(13-17)9-12-28-19/h3-9,12-13H,10-11,14H2,1-2H3
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n/an/a 5.05E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032295
PNG
(CHEMBL3353490)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C25H25ClN2O2S/c1-25(24(30)27(2)16-18-6-8-22(26)9-7-18)11-12-28(25)23(29)15-19-4-3-5-20(14-19)21-10-13-31-17-21/h3-10,13-14,17H,11-12,15-16H2,1-2H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032296
PNG
(CHEMBL3353489)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C27H27ClN2O2/c1-27(26(32)29(2)19-20-11-13-24(28)14-12-20)15-16-30(27)25(31)18-21-7-6-10-23(17-21)22-8-4-3-5-9-22/h3-14,17H,15-16,18-19H2,1-2H3
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n/an/a 7.61E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032299
PNG
(CHEMBL3353487)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(F)cc(F)c1
Show InChI InChI=1S/C21H21ClF2N2O2/c1-21(20(28)25(2)13-14-3-5-16(22)6-4-14)7-8-26(21)19(27)11-15-9-17(23)12-18(24)10-15/h3-6,9-10,12H,7-8,11,13H2,1-2H3
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n/an/a 7.82E+3n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032441
PNG
(CHEMBL3353537)
Show SMILES CC1(CCN1C(=O)Cc1coc2ccccc12)C(=O)N(CCCC(O)=O)Cc1cccc(Cl)c1
Show InChI InChI=1S/C26H27ClN2O5/c1-26(11-13-29(26)23(30)15-19-17-34-22-9-3-2-8-21(19)22)25(33)28(12-5-10-24(31)32)16-18-6-4-7-20(27)14-18/h2-4,6-9,14,17H,5,10-13,15-16H2,1H3,(H,31,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032307
PNG
(CHEMBL3352999)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)NCc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C22H25ClN2O2/c1-15-10-16(2)12-18(11-15)13-20(26)25-9-8-22(25,3)21(27)24-14-17-4-6-19(23)7-5-17/h4-7,10-12H,8-9,13-14H2,1-3H3,(H,24,27)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032335
PNG
(CHEMBL3353509)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)C1CCCCC1
Show InChI InChI=1S/C24H30N2O4S/c1-24(23(30)25(14-7-12-21(27)28)17-8-3-2-4-9-17)13-15-26(24)22(29)19-16-31-20-11-6-5-10-18(19)20/h5-6,10-11,16-17H,2-4,7-9,12-15H2,1H3,(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032275
PNG
(CHEMBL3353506)
Show SMILES CC1(CCN1C(=O)Cn1cnc2ccccc12)C(=O)N(CC(O)=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN4O4/c1-23(22(32)26(14-21(30)31)12-16-6-8-17(24)9-7-16)10-11-28(23)20(29)13-27-15-25-18-4-2-3-5-19(18)27/h2-9,15H,10-14H2,1H3,(H,30,31)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032312
PNG
(CHEMBL3353004)
Show SMILES Cc1cc(C)cc(CC(=O)N2CCC2(C)C(=O)N(CCN)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H30ClN3O2/c1-17-12-18(2)14-20(13-17)15-22(29)28-10-8-24(28,3)23(30)27(11-9-26)16-19-4-6-21(25)7-5-19/h4-7,12-14H,8-11,15-16,26H2,1-3H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032333
PNG
(CHEMBL3353508)
Show SMILES CCCCN(CCCC(O)=O)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12
Show InChI InChI=1S/C22H28N2O4S/c1-3-4-12-23(13-7-10-19(25)26)21(28)22(2)11-14-24(22)20(27)17-15-29-18-9-6-5-8-16(17)18/h5-6,8-9,15H,3-4,7,10-14H2,1-2H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032331
PNG
(CHEMBL3353486)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C21H22Cl2N2O2/c1-21(20(27)24(2)14-16-5-9-18(23)10-6-16)11-12-25(21)19(26)13-15-3-7-17(22)8-4-15/h3-10H,11-14H2,1-2H3
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032286
PNG
(CHEMBL3353497)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C22H21ClN2O2S/c1-22(21(27)24(2)14-15-7-9-17(23)10-8-15)11-12-25(22)20(26)19-13-16-5-3-4-6-18(16)28-19/h3-10,13H,11-12,14H2,1-2H3
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032298
PNG
(CHEMBL3353488)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C27H27ClN2O2/c1-27(26(32)29(2)19-21-10-14-24(28)15-11-21)16-17-30(27)25(31)18-20-8-12-23(13-9-20)22-6-4-3-5-7-22/h3-15H,16-19H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032291
PNG
(CHEMBL3353493)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cnc2ccccn12
Show InChI InChI=1S/C22H23ClN4O2/c1-22(21(29)25(2)15-16-6-8-17(23)9-7-16)10-12-27(22)20(28)13-18-14-24-19-5-3-4-11-26(18)19/h3-9,11,14H,10,12-13,15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032313
PNG
(CHEMBL3353005)
Show SMILES CNC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cc(C)cc(C)c1
Show InChI InChI=1S/C26H33ClN4O3/c1-18-13-19(2)15-21(14-18)16-23(32)31-11-9-26(31,3)24(33)30(12-10-29-25(34)28-4)17-20-5-7-22(27)8-6-20/h5-8,13-15H,9-12,16-17H2,1-4H3,(H2,28,29,34)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032290
PNG
(CHEMBL3353494)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)c1coc2ccccc12
Show InChI InChI=1S/C22H21ClN2O3/c1-22(21(27)24(2)13-15-7-9-16(23)10-8-15)11-12-25(22)20(26)18-14-28-19-6-4-3-5-17(18)19/h3-10,14H,11-13H2,1-2H3
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032287
PNG
(CHEMBL3353496)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)Cc1cccc2ccsc12
Show InChI InChI=1S/C23H23ClN2O2S/c1-23(22(28)25(2)15-16-6-8-19(24)9-7-16)11-12-26(23)20(27)14-18-5-3-4-17-10-13-29-21(17)18/h3-10,13H,11-12,14-15H2,1-2H3
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Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032345
PNG
(CHEMBL3353519)
Show SMILES CC1(CCN1C(=O)c1csc2ccccc12)C(=O)N(CCCC(O)=O)c1ccccn1
Show InChI InChI=1S/C23H23N3O4S/c1-23(22(30)25(13-6-10-20(27)28)19-9-4-5-12-24-19)11-14-26(23)21(29)17-15-31-18-8-3-2-7-16(17)18/h2-5,7-9,12,15H,6,10-11,13-14H2,1H3,(H,27,28)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032332
PNG
(CHEMBL3353507)
Show SMILES CN(CCCC(O)=O)C(=O)C1(C)CCN1C(=O)c1csc2ccccc12
Show InChI InChI=1S/C19H22N2O4S/c1-19(18(25)20(2)10-5-8-16(22)23)9-11-21(19)17(24)14-12-26-15-7-4-3-6-13(14)15/h3-4,6-7,12H,5,8-11H2,1-2H3,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
Free fatty acid receptor 2


(Homo sapiens (Human))		BDBM50032280
PNG
(CHEMBL3353501)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1(C)CCN1C(=O)CCc1csc2ccccc12
Show InChI InChI=1S/C24H25ClN2O2S/c1-24(23(29)26(2)15-17-7-10-19(25)11-8-17)13-14-27(24)22(28)12-9-18-16-30-21-6-4-3-5-20(18)21/h3-8,10-11,16H,9,12-15H2,1-2H3
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n/an/a>2.00E+4n/an/an/an/an/an/a



Galapagos

Curated by ChEMBL


Assay Description
Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilization

J Med Chem 57: 10044-57 (2014)


Article DOI: 10.1021/jm5012885
BindingDB Entry DOI: 10.7270/Q29S1SM9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%