Found 11 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM27502
(3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2H)-isoq...)Show InChI InChI=1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21) | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
| Article PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060678
(CHEMBL3394709)Show InChI InChI=1S/C16H12BrNO2/c17-11-5-6-13-10(9-11)7-8-18-15(19)12-3-1-2-4-14(12)16(13,18)20/h1-6,9,20H,7-8H2 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060697
(CHEMBL3394707)Show InChI InChI=1S/C17H15NO4/c1-22-15-8-10-6-7-18-16(20)11-4-2-3-5-12(11)17(18,21)13(10)9-14(15)19/h2-5,8-9,19,21H,6-7H2,1H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 216 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060696
(CHEMBL3394712)Show InChI InChI=1S/C15H19NO3/c1-18-13-7-6-10-11(15(13)19-2)8-9-16-12(10)4-3-5-14(16)17/h6-7,12H,3-5,8-9H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 565 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060762
(CHEMBL3394705)Show InChI InChI=1S/C18H17NO4/c1-22-15-9-11-7-8-19-17(20)12-5-3-4-6-13(12)18(19,21)14(11)10-16(15)23-2/h3-6,9-10,21H,7-8H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 865 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060677
(CHEMBL3394710)Show InChI InChI=1S/C17H15NO2/c1-11-6-7-14-12(10-11)8-9-18-16(19)13-4-2-3-5-15(13)17(14,18)20/h2-7,10,20H,8-9H2,1H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 977 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060701
(CHEMBL3394706)Show InChI InChI=1S/C18H17NO4/c1-22-15-8-7-14-11(16(15)23-2)9-10-19-17(20)12-5-3-4-6-13(12)18(14,19)21/h3-8,21H,9-10H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 983 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060698
(CHEMBL3394708)Show InChI InChI=1S/C17H15NO3/c1-21-12-6-7-14-11(10-12)8-9-18-16(19)13-4-2-3-5-15(13)17(14,18)20/h2-7,10,20H,8-9H2,1H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060676
(CHEMBL3394704)Show InChI InChI=1S/C18H17NO4/c1-22-14-7-8-15(23-2)16-12(14)9-10-19-17(20)11-5-3-4-6-13(11)18(16,19)21/h3-8,21H,9-10H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060702
(CHEMBL3394711)Show InChI InChI=1S/C14H17NO3/c1-17-10-7-9-5-6-15-11(3-4-13(15)16)14(9)12(8-10)18-2/h7-8,11H,3-6H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human)) | BDBM50060743
(CHEMBL3394703)Show SMILES COc1cc2CCN3C(=O)C4C(C5c6ccccc6C4c4ccccc54)C3(O)c2cc1OC |TLB:26:11:18.13:25.20,17:18:25.20:11.10,24:25:18.13:11.10,THB:8:10:18.13:25.20,14:13:25.20:11.10,21:20:18.13:11.10,(-9.33,-2.12,;-8.6,-1.13,;-7.07,-1.29,;-6.45,-2.7,;-4.91,-2.87,;-4.29,-4.28,;-2.76,-4.44,;-1.85,-3.21,;-.32,-3.05,;.5,-3.96,;,-1.54,;-1.33,-.77,;-1.33,.77,;-1.33,-.77,;-2.67,-1.54,;-2.67,-3.08,;-1.33,-3.85,;,-3.08,;,-1.54,;1.33,-.77,;1.33,.77,;2.67,1.54,;2.67,3.08,;1.33,3.85,;,3.08,;,1.54,;-2.48,-1.8,;-2.85,-.63,;-4.01,-1.62,;-4.63,-.21,;-6.16,-.05,;-6.78,1.36,;-6.05,2.36,)| Show InChI InChI=1S/C28H25NO4/c1-32-21-13-15-11-12-29-27(30)25-23-16-7-3-5-9-18(16)24(19-10-6-4-8-17(19)23)26(25)28(29,31)20(15)14-22(21)33-2/h3-10,13-14,23-26,31H,11-12H2,1-2H3 | PDB MMDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pondicherry University
Curated by ChEMBL
| Assay Description Inhibition of PARP1 (unknown origin) in presence of NAD+ by homogenous fluorescence plate assay |
Bioorg Med Chem 23: 488-98 (2015)
Article DOI: 10.1016/j.bmc.2014.12.017 BindingDB Entry DOI: 10.7270/Q2BV7J9N |
More data for this Ligand-Target Pair | |