Affinity Data by PubMed id=25629304

PubMed code 25629304

Found 3 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Thioredoxin reductase 3 (Homo sapiens (Human))	BDBM50076184 (CHEMBL32856) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lanzhou University Curated by ChEMBL					Assay Description Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs				J Med Chem 58: 1795-805 (2015) Article DOI: 10.1021/jm5016507 BindingDB Entry DOI: 10.7270/Q2KS6T75
Lanzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Thioredoxin reductase 3 (Homo sapiens (Human))	BDBM50076184 (CHEMBL32856) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.28E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lanzhou University Curated by ChEMBL					Assay Description In vitro inhibition of NADPH-reduced TrxR (unknown origin) after 2 hrs incubation by microplate reader				J Med Chem 58: 1795-805 (2015) Article DOI: 10.1021/jm5016507 BindingDB Entry DOI: 10.7270/Q2KS6T75
Lanzhou University Curated by ChEMBL					More data for this Ligand-Target Pair
Thioredoxin reductase 3 (Homo sapiens (Human))	BDBM50384998 (CVD-0019905 \| XANTHOHUMOL) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lanzhou University Curated by ChEMBL					Assay Description Inhibition of TrxR in human HeLa cells assessed as depletion of cellular thiol after 48 hrs				J Med Chem 58: 1795-805 (2015) Article DOI: 10.1021/jm5016507 BindingDB Entry DOI: 10.7270/Q2KS6T75
Lanzhou University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%