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PubMed code 25699140

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080771
PNG
(CHEMBL3422449)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C#N)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H9Cl2N3O2/c18-13-6-5-12(7-14(13)19)22-16(8-15(21-22)17(23)24)11-3-1-10(9-20)2-4-11/h1-8H,(H,23,24)
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n/an/an/a 310n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080859
PNG
(CHEMBL3422464)
Show SMILES OC(=O)c1cc(-c2cccc(CNCc3ccc(cc3)-c3ccc(o3)C(O)=O)c2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H21Cl2N3O5/c30-22-9-8-21(13-23(22)31)34-25(14-24(33-34)28(35)36)20-3-1-2-18(12-20)16-32-15-17-4-6-19(7-5-17)26-10-11-27(39-26)29(37)38/h1-14,32H,15-16H2,(H,35,36)(H,37,38)
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n/an/an/a 57n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080776
PNG
(CHEMBL3422444)
Show SMILES OC(=O)c1cc(-c2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N2O2/c17-12-7-6-11(8-13(12)18)20-15(9-14(19-20)16(21)22)10-4-2-1-3-5-10/h1-9H,(H,21,22)
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n/an/an/a 123n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080784
PNG
(CHEMBL3422436)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1cccc(C)c1)C(O)=O
Show InChI InChI=1S/C18H16N2O3/c1-12-4-3-5-14(10-12)20-17(11-16(19-20)18(21)22)13-6-8-15(23-2)9-7-13/h3-11H,1-2H3,(H,21,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080817
PNG
(CHEMBL1402320)
Show SMILES COc1ccc(cc1)-n1nc(cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H14N2O3/c1-22-14-9-7-13(8-10-14)19-16(11-15(18-19)17(20)21)12-5-3-2-4-6-12/h2-11H,1H3,(H,20,21)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080822
PNG
(CHEMBL3422475)
Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3nc(=O)o[nH]3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C26H17Cl2N5O4S/c27-19-10-9-18(11-20(19)28)33-22(12-21(31-33)25(34)35)15-3-1-14(2-4-15)13-29-24(38)17-7-5-16(6-8-17)23-30-26(36)37-32-23/h1-12H,13H2,(H,29,38)(H,34,35)(H,30,32,36)
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n/an/an/a 9.30n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080824
PNG
(CHEMBL3422473)
Show SMILES NS(=O)(=O)c1ccc(cc1)C(=S)NCc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C24H18Cl2N4O4S2/c25-19-10-7-17(11-20(19)26)30-22(12-21(29-30)24(31)32)15-3-1-14(2-4-15)13-28-23(35)16-5-8-18(9-6-16)36(27,33)34/h1-12H,13H2,(H,28,35)(H,31,32)(H2,27,33,34)
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n/an/an/a 34n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080862
PNG
(CHEMBL3422461)
Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(Br)cc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H16BrCl2N3O2S/c25-17-7-5-16(6-8-17)23(33)28-13-14-1-3-15(4-2-14)22-12-21(24(31)32)29-30(22)18-9-10-19(26)20(27)11-18/h1-12H,13H2,(H,28,33)(H,31,32)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080866
PNG
(CHEMBL3422457)
Show SMILES COc1ccc(cc1)C(=O)NCc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C25H19Cl2N3O4/c1-34-19-9-6-17(7-10-19)24(31)28-14-15-2-4-16(5-3-15)23-13-22(25(32)33)29-30(23)18-8-11-20(26)21(27)12-18/h2-13H,14H2,1H3,(H,28,31)(H,32,33)
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n/an/an/a 72n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080767
PNG
(CHEMBL3422453)
Show SMILES OC(=O)c1cc(-c2ccco2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H8Cl2N2O3/c15-9-4-3-8(6-10(9)16)18-12(13-2-1-5-21-13)7-11(17-18)14(19)20/h1-7H,(H,19,20)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080772
PNG
(CHEMBL3422448)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H10Cl2N2O4/c18-12-6-5-11(7-13(12)19)21-15(8-14(20-21)17(24)25)9-1-3-10(4-2-9)16(22)23/h1-8H,(H,22,23)(H,24,25)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080780
PNG
(CHEMBL3422440)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1cccc(Cl)c1)C(O)=O
Show InChI InChI=1S/C17H13ClN2O3/c1-23-14-7-5-11(6-8-14)16-10-15(17(21)22)19-20(16)13-4-2-3-12(18)9-13/h2-10H,1H3,(H,21,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50443304
PNG
(CHEMBL3088227)
Show SMILES Cc1cccc(c1)-n1nc(cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H14N2O2/c1-12-6-5-9-14(10-12)19-16(11-15(18-19)17(20)21)13-7-3-2-4-8-13/h2-11H,1H3,(H,20,21)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50443304
PNG
(CHEMBL3088227)
Show SMILES Cc1cccc(c1)-n1nc(cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H14N2O2/c1-12-6-5-9-14(10-12)19-16(11-15(18-19)17(20)21)13-7-3-2-4-8-13/h2-11H,1H3,(H,20,21)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080861
PNG
(CHEMBL3422462)
Show SMILES OC(=O)c1cc(-c2ccc(CNS(=O)(=O)c3ccccc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C23H17Cl2N3O4S/c24-19-11-10-17(12-20(19)25)28-22(13-21(27-28)23(29)30)16-8-6-15(7-9-16)14-26-33(31,32)18-4-2-1-3-5-18/h1-13,26H,14H2,(H,29,30)
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n/an/an/a 70n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080865
PNG
(CHEMBL3422458)
Show SMILES OC(=O)c1cc(-c2ccc(CNC(=O)c3ccc(Br)cc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H16BrCl2N3O3/c25-17-7-5-16(6-8-17)23(31)28-13-14-1-3-15(4-2-14)22-12-21(24(32)33)29-30(22)18-9-10-19(26)20(27)11-18/h1-12H,13H2,(H,28,31)(H,32,33)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080781
PNG
(CHEMBL3422439)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C17H13BrN2O3/c1-23-14-8-2-11(3-9-14)16-10-15(17(21)22)19-20(16)13-6-4-12(18)5-7-13/h2-10H,1H3,(H,21,22)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080584
PNG
(CHEMBL3421641)
Show SMILES OC(=O)c1cc(-c2ccc(CNC(=O)c3ccccc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H17Cl2N3O3/c25-19-11-10-18(12-20(19)26)29-22(13-21(28-29)24(31)32)16-8-6-15(7-9-16)14-27-23(30)17-4-2-1-3-5-17/h1-13H,14H2,(H,27,30)(H,31,32)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080770
PNG
(CHEMBL3422450)
Show SMILES NCc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C17H13Cl2N3O2/c18-13-6-5-12(7-14(13)19)22-16(8-15(21-22)17(23)24)11-3-1-10(9-20)2-4-11/h1-8H,9,20H2,(H,23,24)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080775
PNG
(CHEMBL3422445)
Show SMILES Cc1cccc(c1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10-3-2-4-11(7-10)16-9-15(17(22)23)20-21(16)12-5-6-13(18)14(19)8-12/h2-9H,1H3,(H,22,23)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080816
PNG
(CHEMBL1576514)
Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H10Cl2N2O2/c17-11-3-1-10(2-4-11)15-9-14(16(21)22)19-20(15)13-7-5-12(18)6-8-13/h1-9H,(H,21,22)
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n/an/an/a 260n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080820
PNG
(CHEMBL3422476)
Show SMILES OC(=O)c1ccc(o1)-c1ccc(C(=S)NCc2ccc(cc2)-c2ccnn2-c2ccc(Cl)c(Cl)c2)c(Cl)c1
Show InChI InChI=1S/C28H18Cl3N3O3S/c29-21-8-6-19(14-23(21)31)34-24(11-12-33-34)17-3-1-16(2-4-17)15-32-27(38)20-7-5-18(13-22(20)30)25-9-10-26(37-25)28(35)36/h1-14H,15H2,(H,32,38)(H,35,36)
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n/an/an/a 1.70n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080828
PNG
(CHEMBL3422471)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2ccc(cc2Cl)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H18Cl3N3O5S/c30-20-8-7-19(12-22(20)32)35-24(13-23(34-35)28(36)37)15-1-3-16(4-2-15)27(41)33-14-18-6-5-17(11-21(18)31)25-9-10-26(40-25)29(38)39/h1-13H,14H2,(H,33,41)(H,36,37)(H,38,39)
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n/an/an/a 0.480n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080855
PNG
(CHEMBL3422468)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2ccc(cc2)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H19Cl2N3O5S/c30-21-10-9-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-5-7-19(8-6-17)27(40)32-15-16-1-3-18(4-2-16)25-11-12-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)
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n/an/an/a 1.5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080674
PNG
(CHEMBL3422455)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=O)NCc2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H17Cl2N3O3/c25-19-11-10-18(12-20(19)26)29-22(13-21(28-29)24(31)32)16-6-8-17(9-7-16)23(30)27-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,27,30)(H,31,32)
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n/an/an/a 83n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080769
PNG
(CHEMBL3422451)
Show SMILES Nc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C16H11Cl2N3O2/c17-12-6-5-11(7-13(12)18)21-15(8-14(20-21)16(22)23)9-1-3-10(19)4-2-9/h1-8H,19H2,(H,22,23)
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n/an/an/a 227n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080778
PNG
(CHEMBL3422442)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C17H12Cl2N2O3/c1-24-12-5-2-10(3-6-12)16-9-15(17(22)23)20-21(16)11-4-7-13(18)14(19)8-11/h2-9H,1H3,(H,22,23)
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n/an/an/a 79n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080779
PNG
(CHEMBL3422441)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C17H13ClN2O3/c1-23-14-8-2-11(3-9-14)16-10-15(17(21)22)19-20(16)13-6-4-12(18)5-7-13/h2-10H,1H3,(H,21,22)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080856
PNG
(CHEMBL3422467)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2cccc(c2)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H19Cl2N3O5S/c30-21-9-8-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-4-6-18(7-5-17)27(40)32-15-16-2-1-3-19(12-16)25-10-11-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)
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n/an/an/a 2.5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080858
PNG
(CHEMBL3422465)
Show SMILES CC(=O)N(Cc1ccc(cc1)-c1ccc(o1)C(O)=O)Cc1cccc(c1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C31H23Cl2N3O6/c1-18(37)35(16-19-5-7-21(8-6-19)28-11-12-29(42-28)31(40)41)17-20-3-2-4-22(13-20)27-15-26(30(38)39)34-36(27)23-9-10-24(32)25(33)14-23/h2-15H,16-17H2,1H3,(H,38,39)(H,40,41)
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n/an/an/a 8.20n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080782
PNG
(CHEMBL3422438)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1cccc(Br)c1)C(O)=O
Show InChI InChI=1S/C17H13BrN2O3/c1-23-14-7-5-11(6-8-14)16-10-15(17(21)22)19-20(16)13-4-2-3-12(18)9-13/h2-10H,1H3,(H,21,22)
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n/an/an/a 140n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080785
PNG
(CHEMBL3422435)
Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-14(16(22)23)20-21(15)11-5-6-12(18)13(19)7-11/h1-8H,(H,22,23)
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n/an/an/a 67n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080816
PNG
(CHEMBL1576514)
Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H10Cl2N2O2/c17-11-3-1-10(2-4-11)15-9-14(16(21)22)19-20(15)13-7-5-12(18)6-8-13/h1-9H,(H,21,22)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080815
PNG
(CHEMBL3422434)
Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-13(16(22)23)20-21(15)14-6-5-11(18)7-12(14)19/h1-8H,(H,22,23)
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n/an/an/a 410n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080817
PNG
(CHEMBL1402320)
Show SMILES COc1ccc(cc1)-n1nc(cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C17H14N2O3/c1-22-14-9-7-13(8-10-14)19-16(11-15(18-19)17(20)21)12-5-3-2-4-6-12/h2-11H,1H3,(H,20,21)
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n/an/an/a 895n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080825
PNG
(CHEMBL3422472)
Show SMILES OC(=O)c1cc(-c2ccc(CN3CCc4cc(ccc4C3=S)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C31H21Cl2N3O5S/c32-23-8-6-21(14-24(23)33)36-26(15-25(34-36)30(37)38)18-3-1-17(2-4-18)16-35-12-11-19-13-20(5-7-22(19)29(35)42)27-9-10-28(41-27)31(39)40/h1-10,13-15H,11-12,16H2,(H,37,38)(H,39,40)
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n/an/an/a 0.540n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080829
PNG
(CHEMBL3422470)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=O)NCc2ccc(cc2Cl)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H18Cl3N3O6/c30-20-8-7-19(12-22(20)32)35-24(13-23(34-35)28(37)38)15-1-3-16(4-2-15)27(36)33-14-18-6-5-17(11-21(18)31)25-9-10-26(41-25)29(39)40/h1-13H,14H2,(H,33,36)(H,37,38)(H,39,40)
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n/an/an/a 9.40n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080860
PNG
(CHEMBL3422463)
Show SMILES OC(=O)c1cc(-c2ccc(CNS(=O)(=O)c3ccc(OC(F)(F)F)cc3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H16Cl2F3N3O5S/c25-19-10-5-16(11-20(19)26)32-22(12-21(31-32)23(33)34)15-3-1-14(2-4-15)13-30-38(35,36)18-8-6-17(7-9-18)37-24(27,28)29/h1-12,30H,13H2,(H,33,34)
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n/an/an/a 56n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080863
PNG
(CHEMBL3422460)
Show SMILES COc1ccc(CNC(=S)c2ccc(cc2)-c2cc(nn2-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1
Show InChI InChI=1S/C25H19Cl2N3O3S/c1-33-19-9-2-15(3-10-19)14-28-24(34)17-6-4-16(5-7-17)23-13-22(25(31)32)29-30(23)18-8-11-20(26)21(27)12-18/h2-13H,14H2,1H3,(H,28,34)(H,31,32)
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n/an/an/a 23n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080864
PNG
(CHEMBL3422459)
Show SMILES OC(=O)c1cc(-c2ccc(cc2)C(=S)NCc2ccccc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C24H17Cl2N3O2S/c25-19-11-10-18(12-20(19)26)29-22(13-21(28-29)24(30)31)16-6-8-17(9-7-16)23(32)27-14-15-4-2-1-3-5-15/h1-13H,14H2,(H,27,32)(H,30,31)
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n/an/an/a 18n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080673
PNG
(CHEMBL3422456)
Show SMILES COc1ccc(CNC(=O)c2ccc(cc2)-c2cc(nn2-c2ccc(Cl)c(Cl)c2)C(O)=O)cc1
Show InChI InChI=1S/C25H19Cl2N3O4/c1-34-19-9-2-15(3-10-19)14-28-24(31)17-6-4-16(5-7-17)23-13-22(25(32)33)29-30(23)18-8-11-20(26)21(27)12-18/h2-13H,14H2,1H3,(H,28,31)(H,32,33)
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n/an/an/a 45n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080768
PNG
(CHEMBL3422452)
Show SMILES OC(=O)c1cc(-c2ccc(O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N2O3/c17-12-6-3-10(7-13(12)18)20-15(8-14(19-20)16(22)23)9-1-4-11(21)5-2-9/h1-8,21H,(H,22,23)
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n/an/an/a 104n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080774
PNG
(CHEMBL3422446)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(Cl)c(Cl)c1)C(O)=O
Show InChI InChI=1S/C17H12Cl2N2O2/c1-10-2-4-11(5-3-10)16-9-15(17(22)23)20-21(16)12-6-7-13(18)14(19)8-12/h2-9H,1H3,(H,22,23)
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n/an/an/a 72n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080815
PNG
(CHEMBL3422434)
Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-13(16(22)23)20-21(15)14-6-5-11(18)7-12(14)19/h1-8H,(H,22,23)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080785
PNG
(CHEMBL3422435)
Show SMILES OC(=O)c1cc(-c2ccc(Cl)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H9Cl3N2O2/c17-10-3-1-9(2-4-10)15-8-14(16(22)23)20-21(15)11-5-6-12(18)13(19)7-11/h1-8H,(H,22,23)
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n/an/an/a 54n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080693
PNG
(CHEMBL3422454)
Show SMILES OC(=O)c1cc(Cc2ccc(O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H12Cl2N2O3/c18-14-6-3-11(8-15(14)19)21-12(9-16(20-21)17(23)24)7-10-1-4-13(22)5-2-10/h1-6,8-9,22H,7H2,(H,23,24)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080777
PNG
(CHEMBL3422443)
Show SMILES COc1ccc(cc1)-c1cc(nn1C1CCCCC1)C(O)=O
Show InChI InChI=1S/C17H20N2O3/c1-22-14-9-7-12(8-10-14)16-11-15(17(20)21)18-19(16)13-5-3-2-4-6-13/h7-11,13H,2-6H2,1H3,(H,20,21)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080783
PNG
(CHEMBL3422437)
Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C18H16N2O3/c1-12-3-7-14(8-4-12)20-17(11-16(19-20)18(21)22)13-5-9-15(23-2)10-6-13/h3-11H,1-2H3,(H,21,22)
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n/an/an/a>500n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080819
PNG
(CHEMBL1709075)
Show SMILES OC(=O)c1cc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C16H12N2O2/c19-16(20)14-11-15(12-7-3-1-4-8-12)18(17-14)13-9-5-2-6-10-13/h1-11H,(H,19,20)
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n/an/an/a 1.15E+3n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) by HSQC NMR-based titration method

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080823
PNG
(CHEMBL3422474)
Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3nnn[nH]3)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H17Cl2N7O2S/c26-19-10-9-18(11-20(19)27)34-22(12-21(31-34)25(35)36)15-3-1-14(2-4-15)13-28-24(37)17-7-5-16(6-8-17)23-29-32-33-30-23/h1-12H,13H2,(H,28,37)(H,35,36)(H,29,30,32,33)
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n/an/an/a 2.20n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080853
PNG
(CHEMBL3422469)
Show SMILES OC(=O)c1cc(-c2ccc(CNC(=S)c3ccc(cc3)-c3ccc(o3)C(O)=O)cc2)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H19Cl2N3O5S/c30-21-10-9-20(13-22(21)31)34-24(14-23(33-34)28(35)36)17-3-1-16(2-4-17)15-32-27(40)19-7-5-18(6-8-19)25-11-12-26(39-25)29(37)38/h1-14H,15H2,(H,32,40)(H,35,36)(H,37,38)
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n/an/an/a 0.550n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080857
PNG
(CHEMBL3422466)
Show SMILES OC(=O)c1cc(-c2cccc(c2)C(=O)NCc2ccc(cc2)-c2ccc(o2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H19Cl2N3O6/c30-21-9-8-20(13-22(21)31)34-24(14-23(33-34)28(36)37)18-2-1-3-19(12-18)27(35)32-15-16-4-6-17(7-5-16)25-10-11-26(40-25)29(38)39/h1-14H,15H2,(H,32,35)(H,36,37)(H,38,39)
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n/an/an/a 22n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50080773
PNG
(CHEMBL3422447)
Show SMILES OC(=O)c1cc(-c2cccc(c2)C(O)=O)n(n1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H10Cl2N2O4/c18-12-5-4-11(7-13(12)19)21-15(8-14(20-21)17(24)25)9-2-1-3-10(6-9)16(22)23/h1-8H,(H,22,23)(H,24,25)
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n/an/an/a 129n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to RPA70N protein (unknown origin) incubated for 1 hr using FITC-ATRIP/FITC-ATRIP2 peptide probe by fluorescence polarization anisot...

ACS Med Chem Lett 6: 140-5 (2015)


Article DOI: 10.1021/ml5003629
BindingDB Entry DOI: 10.7270/Q2HM5B5R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%