Affinity Data by PubMed id=25801156

PubMed code 25801156

Found 26 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067181 (CHEMBL3401726) Show SMILES Clc1cc(Cl)cc(c1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067180 (CHEMBL3401725) Show SMILES Clc1ccc(cc1Cl)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067173 (CHEMBL3401720) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067178 (CHEMBL3401723) Show SMILES Clc1ccc(Cl)c(c1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067185 (CHEMBL1578123) Show SMILES O=C(Nc1nc2ccccc2[nH]1)C1CCC1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM39107 (MLS000092864 \| N-(1H-benzimidazol-2-yl)-4-fluorany...) Show SMILES Fc1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067177 (CHEMBL1402439) Show SMILES CN(C)c1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067183 (CHEMBL3401728) Show SMILES O=C(Nc1nc2ccccc2[nH]1)\C=C\c1ccncc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50275235 (CHEMBL486569 \| N-(1H-benzo[d]imidazol-2-yl)-4-chlo...) Show SMILES Clc1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM53441 (MLS001000876 \| N-(1H-benzimidazol-2-yl)-3-chlorany...) Show SMILES Clc1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50184701 (CHEMBL210658 \| N-(1H-benzo[d]imidazol-2-yl)-3-nitr...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM95957 (MLS000680654 \| N-(1H-benzimidazol-2-yl)-4-nitro-be...) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067179 (CHEMBL3401724) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM38984 (MLS000092863 \| N-(1H-benzimidazol-2-yl)-2-fluorany...) Show SMILES Fc1ccccc1C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067184 (CHEMBL3401729) Show SMILES O=C(Nc1nc2ccccc2[nH]1)C1CCCCC1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067176 (CHEMBL3401722) Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1ccncc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067174 (CHEMBL3401721) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067170 (CHEMBL3401716) Show SMILES FC(F)(F)c1ccccc1C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067175 (CHEMBL1604245) Show SMILES COc1ccc(cc1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067169 (CHEMBL3401715) Show SMILES Clc1ccccc1C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM48291 (MLS000566231 \| N-(1H-benzimidazol-2-yl)-3-methoxy-...) Show SMILES COc1cccc(c1)C(=O)Nc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50156074 (1,2-bis(3-fluorobenzylidene)hydrazine \| CHEMBL3718...) Show SMILES Fc1cccc(\C=N\N=C\c2cccc(F)c2)c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067182 (CHEMBL3401727) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067172 (CHEMBL3401719) Show SMILES Clc1cccc(c1)C(=O)Sc1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM48290 (MLS000566310 \| N-(1H-benzimidazol-2-yl)benzamide \|...) Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50067171 (CHEMBL3401718) Show SMILES CN(C(=O)c1cccc(Cl)c1)c1nc2ccccc2[nH]1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulator activity at mGluR5 in mouse BV2 cells assessed as inhibition of nitric oxide production pre-treated 1 hr before lipopol...				Bioorg Med Chem 23: 2211-20 (2015) Article DOI: 10.1016/j.bmc.2015.02.054 BindingDB Entry DOI: 10.7270/Q2D2209T
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%