Found 17 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085571
(CHEMBL3427709)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@@H]2CCc3c2cccc3C)cc1 |r| Show InChI InChI=1S/C21H24O4/c1-3-24-20(13-21(22)23)15-7-9-16(10-8-15)25-19-12-11-17-14(2)5-4-6-18(17)19/h4-10,19-20H,3,11-13H2,1-2H3,(H,22,23)/t19-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50019110
(CHEMBL3288362)Show InChI InChI=1S/C19H22O4/c1-3-22-18(12-19(20)21)15-8-10-17(11-9-15)23-13-16-7-5-4-6-14(16)2/h4-11,18H,3,12-13H2,1-2H3,(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085592
(CHEMBL3427704)Show SMILES CCO[C@H](CC(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C18H18Cl2O4/c1-2-23-17(10-18(21)22)13-4-6-14(7-5-13)24-11-12-3-8-15(19)16(20)9-12/h3-9,17H,2,10-11H2,1H3,(H,21,22)/t17-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085594
(CHEMBL3427702)Show InChI InChI=1S/C18H18Cl2O4/c1-2-23-17(10-18(21)22)13-4-6-14(7-5-13)24-11-12-3-8-15(19)16(20)9-12/h3-9,17H,2,10-11H2,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
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| Purchase
CHEMBL
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085548
(CHEMBL3425533)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(OCc2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H19F3O4/c1-2-25-17(11-18(23)24)14-5-9-16(10-6-14)26-12-13-3-7-15(8-4-13)19(20,21)22/h3-10,17H,2,11-12H2,1H3,(H,23,24)/t17-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at PPARgamma (unknown origin) |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085569
(CHEMBL3427711)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@@H]2CCc3c2cccc3Cl)cc1 |r| Show InChI InChI=1S/C20H21ClO4/c1-2-24-19(12-20(22)23)13-6-8-14(9-7-13)25-18-11-10-15-16(18)4-3-5-17(15)21/h3-9,18-19H,2,10-12H2,1H3,(H,22,23)/t18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085572
(CHEMBL3427708)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@@H]2CCCc3ccccc23)cc1 |r| Show InChI InChI=1S/C21H24O4/c1-2-24-20(14-21(22)23)16-10-12-17(13-11-16)25-19-9-5-7-15-6-3-4-8-18(15)19/h3-4,6,8,10-13,19-20H,2,5,7,9,14H2,1H3,(H,22,23)/t19-,20+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 62 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085549
(CHEMBL3427715)Show SMILES CCO[C@H](CC(O)=O)c1ccc(O[C@H]2CCc3c2cccc3C(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H21F3O4/c1-2-27-19(12-20(25)26)13-6-8-14(9-7-13)28-18-11-10-15-16(18)4-3-5-17(15)21(22,23)24/h3-9,18-19H,2,10-12H2,1H3,(H,25,26)/t18-,19+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085552
(CHEMBL3427713)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@H]2CCc3c2cccc3C(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H21F3O4/c1-2-27-19(12-20(25)26)13-6-8-14(9-7-13)28-18-11-10-15-16(18)4-3-5-17(15)21(22,23)24/h3-9,18-19H,2,10-12H2,1H3,(H,25,26)/t18-,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085574
(CHEMBL3427706)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@H]2CCc3ccccc23)cc1 |r| Show InChI InChI=1S/C20H22O4/c1-2-23-19(13-20(21)22)15-7-10-16(11-8-15)24-18-12-9-14-5-3-4-6-17(14)18/h3-8,10-11,18-19H,2,9,12-13H2,1H3,(H,21,22)/t18-,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 69 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085568
(CHEMBL3427712)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H21F3O4/c1-2-27-19(12-20(25)26)13-6-8-14(9-7-13)28-18-11-10-15-16(18)4-3-5-17(15)21(22,23)24/h3-9,18-19H,2,10-12H2,1H3,(H,25,26)/t18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085593
(CHEMBL3427703)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1 |r| Show InChI InChI=1S/C18H18Cl2O4/c1-2-23-17(10-18(21)22)13-4-6-14(7-5-13)24-11-12-3-8-15(19)16(20)9-12/h3-9,17H,2,10-11H2,1H3,(H,21,22)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085550
(CHEMBL3427714)Show SMILES CCO[C@H](CC(O)=O)c1ccc(O[C@@H]2CCc3c2cccc3C(F)(F)F)cc1 |r| Show InChI InChI=1S/C21H21F3O4/c1-2-27-19(12-20(25)26)13-6-8-14(9-7-13)28-18-11-10-15-16(18)4-3-5-17(15)21(22,23)24/h3-9,18-19H,2,10-12H2,1H3,(H,25,26)/t18-,19-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 330 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085570
(CHEMBL3427710)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@@H]2CCc3c2cccc3OCC)cc1 |r| Show InChI InChI=1S/C22H26O5/c1-3-25-19-7-5-6-17-18(19)12-13-20(17)27-16-10-8-15(9-11-16)21(26-4-2)14-22(23)24/h5-11,20-21H,3-4,12-14H2,1-2H3,(H,23,24)/t20-,21+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085573
(CHEMBL3427707)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(OC2Cc3ccccc3C2)cc1 |r| Show InChI InChI=1S/C20H22O4/c1-2-23-19(13-20(21)22)14-7-9-17(10-8-14)24-18-11-15-5-3-4-6-16(15)12-18/h3-10,18-19H,2,11-13H2,1H3,(H,21,22)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 83 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085548
(CHEMBL3425533)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(OCc2ccc(cc2)C(F)(F)F)cc1 |r| Show InChI InChI=1S/C19H19F3O4/c1-2-25-17(11-18(23)24)14-5-9-16(10-6-14)26-12-13-3-7-15(8-4-13)19(20,21)22/h3-10,17H,2,11-12H2,1H3,(H,23,24)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
Free fatty acid receptor 1
(Homo sapiens (Human)) | BDBM50085591
(CHEMBL3427705)Show SMILES CCO[C@@H](CC(O)=O)c1ccc(O[C@@H]2CCc3ccccc23)cc1 |r| Show InChI InChI=1S/C20H22O4/c1-2-23-19(13-20(21)22)15-7-10-16(11-8-15)24-18-12-9-14-5-3-4-6-17(14)18/h3-8,10-11,18-19H,2,9,12-13H2,1H3,(H,21,22)/t18-,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 31 | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux by FLIPR assay |
ACS Med Chem Lett 6: 266-70 (2015)
Article DOI: 10.1021/ml500391n
BindingDB Entry DOI: 10.7270/Q26T0PBH |
More data for this
Ligand-Target Pair | |
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