Affinity Data by PubMed id=25937015

PubMed code 25937015

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083317 (CHEMBL3423096) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083267 (CHEMBL3423270) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083334 (CHEMBL3423094) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083318 (CHEMBL3423095) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083316 (CHEMBL3423097) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083313 (CHEMBL3423100) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083315 (CHEMBL3423098) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083265 (CHEMBL3423272) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50156074 (1,2-bis(3-fluorobenzylidene)hydrazine \| CHEMBL3718...) Show SMILES Fc1cccc(\C=N\N=C\c2cccc(F)c2)c1 Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.36E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083353 (CHEMBL3423092) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083263 (CHEMBL3423274) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083352 (CHEMBL3423093) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083266 (CHEMBL3423271) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083264 (CHEMBL3423273) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083354 (CHEMBL3423091) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Mus musculus)	BDBM50083314 (CHEMBL3423099) Show SMILES Show InChI	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Maryland Curated by ChEMBL					Assay Description Positive allosteric modulation at mGluR5 in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 1 hr prior to LPS chall...				Bioorg Med Chem Lett 25: 2275-9 (2015) Article DOI: 10.1016/j.bmcl.2015.04.042 BindingDB Entry DOI: 10.7270/Q2708359
University of Maryland Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%