Affinity Data by PubMed id=26081289

PubMed code 26081289

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106762 (CHEMBL3601277) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106760 (CHEMBL3601279) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106763 (CHEMBL3601276) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106761 (CHEMBL3601278) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50428519 (CHEMBL2336619) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 2 (Homo sapiens (Human))	BDBM50106759 (CHEMBL3601280) Show SMILES CC(=O)Oc1ccccc1C(=O)OCCCCO[N+]([O-])=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazi...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50106760 (CHEMBL3601279) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50106759 (CHEMBL3601280) Show SMILES CC(=O)Oc1ccccc1C(=O)OCCCCO[N+]([O-])=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50106762 (CHEMBL3601277) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM11639 (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50428519 (CHEMBL2336619) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50106761 (CHEMBL3601278) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair
Prostaglandin G/H synthase 1 (Ovis aries (Sheep))	BDBM50106763 (CHEMBL3601276) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Technische Universitat Dresden Curated by ChEMBL					Assay Description Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resoru...				Bioorg Med Chem Lett 25: 3295-300 (2015) Article DOI: 10.1016/j.bmcl.2015.05.059 BindingDB Entry DOI: 10.7270/Q23N2555
Technische Universitat Dresden Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%