Found 18 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107317
![PNG](/data/jpeg/tenK5010/BindingDB_50107317.png) (CHEMBL3601177)Show InChI InChI=1S/C21H15ClO3/c22-18-13-11-17(12-14-18)21(24)25-20(16-9-5-2-6-10-16)19(23)15-7-3-1-4-8-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107317
![PNG](/data/jpeg/tenK5010/BindingDB_50107317.png) (CHEMBL3601177)Show InChI InChI=1S/C21H15ClO3/c22-18-13-11-17(12-14-18)21(24)25-20(16-9-5-2-6-10-16)19(23)15-7-3-1-4-8-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107321
![PNG](/data/jpeg/tenK5010/BindingDB_50107321.png) (CHEMBL3601173)Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)OC(C(=O)c1ccccc1)c1ccccc1 Show InChI InChI=1S/C21H15NO5/c23-19(15-7-3-1-4-8-15)20(16-9-5-2-6-10-16)27-21(24)17-11-13-18(14-12-17)22(25)26/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107321
![PNG](/data/jpeg/tenK5010/BindingDB_50107321.png) (CHEMBL3601173)Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)OC(C(=O)c1ccccc1)c1ccccc1 Show InChI InChI=1S/C21H15NO5/c23-19(15-7-3-1-4-8-15)20(16-9-5-2-6-10-16)27-21(24)17-11-13-18(14-12-17)22(25)26/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107320
![PNG](/data/jpeg/tenK5010/BindingDB_50107320.png) (CHEMBL3601174)Show InChI InChI=1S/C21H15FO3/c22-18-14-8-7-13-17(18)21(24)25-20(16-11-5-2-6-12-16)19(23)15-9-3-1-4-10-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107320
![PNG](/data/jpeg/tenK5010/BindingDB_50107320.png) (CHEMBL3601174)Show InChI InChI=1S/C21H15FO3/c22-18-14-8-7-13-17(18)21(24)25-20(16-11-5-2-6-12-16)19(23)15-9-3-1-4-10-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107319
![PNG](/data/jpeg/tenK5010/BindingDB_50107319.png) (CHEMBL3601175)Show InChI InChI=1S/C21H15FO3/c22-18-13-7-12-17(14-18)21(24)25-20(16-10-5-2-6-11-16)19(23)15-8-3-1-4-9-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107319
![PNG](/data/jpeg/tenK5010/BindingDB_50107319.png) (CHEMBL3601175)Show InChI InChI=1S/C21H15FO3/c22-18-13-7-12-17(14-18)21(24)25-20(16-10-5-2-6-11-16)19(23)15-8-3-1-4-9-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM22760
![PNG](/data/jpeg/tenK2/BindingDB_22760.png) (2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one | Be...)Show InChI InChI=1S/C16H16O4/c1-19-13-7-3-11(4-8-13)15(17)16(18)12-5-9-14(20-2)10-6-12/h3-10,15,17H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.17E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM22760
![PNG](/data/jpeg/tenK2/BindingDB_22760.png) (2-hydroxy-1,2-bis(4-methoxyphenyl)ethan-1-one | Be...)Show InChI InChI=1S/C16H16O4/c1-19-13-7-3-11(4-8-13)15(17)16(18)12-5-9-14(20-2)10-6-12/h3-10,15,17H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.17E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107318
![PNG](/data/jpeg/tenK5010/BindingDB_50107318.png) (CHEMBL3601176)Show InChI InChI=1S/C21H15FO3/c22-18-13-11-17(12-14-18)21(24)25-20(16-9-5-2-6-10-16)19(23)15-7-3-1-4-8-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.29E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107318
![PNG](/data/jpeg/tenK5010/BindingDB_50107318.png) (CHEMBL3601176)Show InChI InChI=1S/C21H15FO3/c22-18-13-11-17(12-14-18)21(24)25-20(16-9-5-2-6-10-16)19(23)15-7-3-1-4-8-15/h1-14,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.29E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM22728
![PNG](/data/jpeg/tenK2/BindingDB_22728.png) (2-hydroxy-1,2-diphenylethan-1-one | Benzoin | CHEM...)Show InChI InChI=1S/C14H12O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10,13,15H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.12E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM22728
![PNG](/data/jpeg/tenK2/BindingDB_22728.png) (2-hydroxy-1,2-diphenylethan-1-one | Benzoin | CHEM...)Show InChI InChI=1S/C14H12O2/c15-13(11-7-3-1-4-8-11)14(16)12-9-5-2-6-10-12/h1-10,13,15H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.12E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107322
![PNG](/data/jpeg/tenK5010/BindingDB_50107322.png) (CHEMBL3601172)Show InChI InChI=1S/C21H16O3/c22-19(16-10-4-1-5-11-16)20(17-12-6-2-7-13-17)24-21(23)18-14-8-3-9-15-18/h1-15,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.66E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107322
![PNG](/data/jpeg/tenK5010/BindingDB_50107322.png) (CHEMBL3601172)Show InChI InChI=1S/C21H16O3/c22-19(16-10-4-1-5-11-16)20(17-12-6-2-7-13-17)24-21(23)18-14-8-3-9-15-18/h1-15,20H | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.66E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107316
![PNG](/data/jpeg/tenK5010/BindingDB_50107316.png) (CHEMBL3601178)Show SMILES COc1ccc(cc1)C(OC(=O)c1ccc(F)cc1)C(=O)c1ccc(OC)cc1 Show InChI InChI=1S/C23H19FO5/c1-27-19-11-5-15(6-12-19)21(25)22(16-7-13-20(28-2)14-8-16)29-23(26)17-3-9-18(24)10-4-17/h3-14,22H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.82E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha H1047R mutant in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50107316
![PNG](/data/jpeg/tenK5010/BindingDB_50107316.png) (CHEMBL3601178)Show SMILES COc1ccc(cc1)C(OC(=O)c1ccc(F)cc1)C(=O)c1ccc(OC)cc1 Show InChI InChI=1S/C23H19FO5/c1-27-19-11-5-15(6-12-19)21(25)22(16-7-13-20(28-2)14-8-16)29-23(26)17-3-9-18(24)10-4-17/h3-14,22H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.82E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Al-Zaytoonah University of Jordan
Curated by ChEMBL
| Assay Description Inhibition of PI3Kalpha in human HCT116 cells assessed as cell growth inhibition after 24 hrs by MTT assay |
Bioorg Med Chem Lett 25: 3120-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.011 BindingDB Entry DOI: 10.7270/Q2XW4MKJ |
More data for this Ligand-Target Pair | |