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PubMed code 26101570

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092976
PNG
(CHEMBL3586478)
Show SMILES CSCC[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C13H17NO4S3/c1-19-6-4-10(13(18)21-8-12(16)17)14-11(15)7-9-3-2-5-20-9/h2-3,5,10H,4,6-8H2,1H3,(H,14,15)(H,16,17)/t10-/m0/s1
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 110n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092982
PNG
(CHEMBL3585360)
Show SMILES OC(=O)CSC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1cccs1 |r|
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 170n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092980
PNG
(CHEMBL3586479)
Show SMILES OC[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C11H13NO5S2/c13-5-8(11(17)19-6-10(15)16)12-9(14)4-7-2-1-3-18-7/h1-3,8,13H,4-6H2,(H,12,14)(H,15,16)/t8-/m0/s1
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 170n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092997
PNG
(CHEMBL3586481)
Show SMILES OC(=O)CSC(=O)[C@H](CCCCNC(=O)Cc1cccs1)NC(=O)Cc1cccs1 |r|
Show InChI InChI=1S/C20H24N2O5S3/c23-17(11-14-5-3-9-28-14)21-8-2-1-7-16(20(27)30-13-19(25)26)22-18(24)12-15-6-4-10-29-15/h3-6,9-10,16H,1-2,7-8,11-13H2,(H,21,23)(H,22,24)(H,25,26)/t16-/m0/s1
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 190n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092979
PNG
(CHEMBL3586477)
Show SMILES CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C14H19NO4S2/c1-9(2)6-11(14(19)21-8-13(17)18)15-12(16)7-10-4-3-5-20-10/h3-5,9,11H,6-8H2,1-2H3,(H,15,16)(H,17,18)/t11-/m0/s1
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 210n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092977
PNG
(CHEMBL3586474)
Show SMILES OC(=O)CSC(=O)CNC(=O)Cc1cccs1
Show InChI InChI=1S/C10H11NO4S2/c12-8(4-7-2-1-3-16-7)11-5-10(15)17-6-9(13)14/h1-3H,4-6H2,(H,11,12)(H,13,14)
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 280n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092842
PNG
(CHEMBL3586476)
Show SMILES CC(C)[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
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 280n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092978
PNG
(CHEMBL3586475)
Show SMILES C[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C11H13NO4S2/c1-7(11(16)18-6-10(14)15)12-9(13)5-8-3-2-4-17-8/h2-4,7H,5-6H2,1H3,(H,12,13)(H,14,15)/t7-/m0/s1
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 410n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50093027
PNG
(CHEMBL3586482)
Show SMILES OC(=O)CSC(=O)[C@@H]1CCCN1C(=O)Cc1cccs1 |r|
Show InChI InChI=1S/C35H46N4O9/c1-5-21(4)30(36-27(40)13-14-28(41)42)32(44)37-29(20(2)3)33(45)39-18-24(17-26(39)31(43)38-35(15-16-35)34(46)47)48-19-23-11-8-10-22-9-6-7-12-25(22)23/h6-12,20-21,24,26,29-30H,5,13-19H2,1-4H3,(H,36,40)(H,37,44)(H,38,43)(H,41,42)(H,46,47)/t21?,24-,26+,29+,30+/m1/s1
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 870n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092981
PNG
(CHEMBL3586480)
Show SMILES OC(=O)CSC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1cccs1 |r|
Show InChI InChI=1S/C17H17NO4S2/c19-15(10-13-7-4-8-23-13)18-14(17(22)24-11-16(20)21)9-12-5-2-1-3-6-12/h1-8,14H,9-11H2,(H,18,19)(H,20,21)/t14-/m0/s1
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 950n/an/an/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Mixed-type inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mi...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092976
PNG
(CHEMBL3586478)
Show SMILES CSCC[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C13H17NO4S3/c1-19-6-4-10(13(18)21-8-12(16)17)14-11(15)7-9-3-2-5-20-9/h2-3,5,10H,4,6-8H2,1H3,(H,14,15)(H,16,17)/t10-/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092979
PNG
(CHEMBL3586477)
Show SMILES CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C14H19NO4S2/c1-9(2)6-11(14(19)21-8-13(17)18)15-12(16)7-10-4-3-5-20-10/h3-5,9,11H,6-8H2,1-2H3,(H,15,16)(H,17,18)/t11-/m0/s1
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n/an/a 69n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092982
PNG
(CHEMBL3585360)
Show SMILES OC(=O)CSC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cc1cccs1 |r|
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n/an/a 290n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092842
PNG
(CHEMBL3586476)
Show SMILES CC(C)[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
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n/an/a 450n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50093027
PNG
(CHEMBL3586482)
Show SMILES OC(=O)CSC(=O)[C@@H]1CCCN1C(=O)Cc1cccs1 |r|
Show InChI InChI=1S/C35H46N4O9/c1-5-21(4)30(36-27(40)13-14-28(41)42)32(44)37-29(20(2)3)33(45)39-18-24(17-26(39)31(43)38-35(15-16-35)34(46)47)48-19-23-11-8-10-22-9-6-7-12-25(22)23/h6-12,20-21,24,26,29-30H,5,13-19H2,1-4H3,(H,36,40)(H,37,44)(H,38,43)(H,41,42)(H,46,47)/t21?,24-,26+,29+,30+/m1/s1
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n/an/a 450n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092977
PNG
(CHEMBL3586474)
Show SMILES OC(=O)CSC(=O)CNC(=O)Cc1cccs1
Show InChI InChI=1S/C10H11NO4S2/c12-8(4-7-2-1-3-16-7)11-5-10(15)17-6-9(13)14/h1-3H,4-6H2,(H,11,12)(H,13,14)
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n/an/a 840n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092978
PNG
(CHEMBL3586475)
Show SMILES C[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C11H13NO4S2/c1-7(11(16)18-6-10(14)15)12-9(13)5-8-3-2-4-17-8/h2-4,7H,5-6H2,1H3,(H,12,13)(H,14,15)/t7-/m0/s1
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n/an/a 910n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092997
PNG
(CHEMBL3586481)
Show SMILES OC(=O)CSC(=O)[C@H](CCCCNC(=O)Cc1cccs1)NC(=O)Cc1cccs1 |r|
Show InChI InChI=1S/C20H24N2O5S3/c23-17(11-14-5-3-9-28-14)21-8-2-1-7-16(20(27)30-13-19(25)26)22-18(24)12-15-6-4-10-29-15/h3-6,9-10,16H,1-2,7-8,11-13H2,(H,21,23)(H,22,24)(H,25,26)/t16-/m0/s1
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n/an/a 1.08E+3n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092980
PNG
(CHEMBL3586479)
Show SMILES OC[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C11H13NO5S2/c13-5-8(11(17)19-6-10(15)16)12-9(14)4-7-2-1-3-18-7/h1-3,8,13H,4-6H2,(H,12,14)(H,15,16)/t8-/m0/s1
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n/an/a 1.49E+3n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase L1 type 3


(Stenotrophomonas maltophilia)		BDBM50092981
PNG
(CHEMBL3586480)
Show SMILES OC(=O)CSC(=O)[C@H](Cc1ccccc1)NC(=O)Cc1cccs1 |r|
Show InChI InChI=1S/C17H17NO4S2/c19-15(10-13-7-4-8-23-13)18-14(17(22)24-11-16(20)21)9-12-5-2-1-3-6-12/h1-8,14H,9-11H2,(H,18,19)(H,20,21)/t14-/m0/s1
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PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Stenotrophomonas maltophilia L1 overexpressed in Escherichia coli BL21 (DE3) using imipenem as substrate incubated for 30 mins prior to...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase type 2


(Bacteroides fragilis)		BDBM50092842
PNG
(CHEMBL3586476)
Show SMILES CC(C)[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C16H18N2O2.C4H4O4/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;5-3(6)1-2-4(7)8/h5-8,10-12H,1-4,9H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-
PDB
MMDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.85E+4n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Bacteroides fragilis CcrA overexpressed in Escherichia coli BL21 (DE3) using cefazolin as substrate incubated for 30 mins prior to test...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
Metallo-beta-lactamase type 2


(Bacteroides fragilis)		BDBM50092976
PNG
(CHEMBL3586478)
Show SMILES CSCC[C@H](NC(=O)Cc1cccs1)C(=O)SCC(O)=O |r|
Show InChI InChI=1S/C13H17NO4S3/c1-19-6-4-10(13(18)21-8-12(16)17)14-11(15)7-9-3-2-5-20-9/h2-3,5,10H,4,6-8H2,1H3,(H,14,15)(H,16,17)/t10-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.23E+5n/an/an/an/an/an/a



Northwest University

Curated by ChEMBL


Assay Description
Inhibition of Bacteroides fragilis CcrA overexpressed in Escherichia coli BL21 (DE3) using cefazolin as substrate incubated for 30 mins prior to test...

ACS Med Chem Lett 6: 660-4 (2015)


Article DOI: 10.1021/acsmedchemlett.5b00098
BindingDB Entry DOI: 10.7270/Q2M04769
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%