Affinity Data by PubMed id=26122774

PubMed code 26122774

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498393 (CHEMBL3594331) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498392 (CHEMBL3594330) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498399 (CHEMBL3593256) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM19149 (CHEMBL98 \| N-hydroxy-N'-phenyloctanediamide \| SAHA...) Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498395 (CHEMBL3594332) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498391 (CHEMBL3594297) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498388 (CHEMBL3594329) Show SMILES ONC(=O)CCCCOC(=O)c1cccc2[n+]([O-])onc12 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498390 (CHEMBL3594296) Show SMILES Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	437	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498396 (CHEMBL3594295) Show SMILES ONC(=O)CCCCOC(=O)c1ccc2[n+]([O-])onc2c1 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.21E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498389 (CHEMBL3594294) Show SMILES ONC(=O)CCCOC(=O)c1ccc2[n+]([O-])onc2c1 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498397 (CHEMBL3594298) Show SMILES ONC(=O)CCCOC(=O)c1cccc2[n+]([O-])onc12 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.81E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498394 (CHEMBL3594333) Show SMILES OC(=O)c1cccc2[n+]([O-])onc12 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone deacetylase (HDAC1 and HDAC2) (Homo sapiens (Human))	BDBM50498398 (CHEMBL2270111) Show SMILES OC(=O)c1ccc2[n+]([O-])onc2c1 Show InChI	PDB UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of HDAC1/2 in human HeLa cells using Boc-Lys (acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition measured af...				Bioorg Med Chem 23: 4481-4488 (2015) Article DOI: 10.1016/j.bmc.2015.06.015 BindingDB Entry DOI: 10.7270/Q2PG1VQS
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%