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PubMed code 26259807

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115425
PNG
(CHEMBL3608593)
Show SMILES Fc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C16H9ClF2N2OS/c17-11-4-2-1-3-10(11)15(22)14-8-20-16(23-14)21-13-6-5-9(18)7-12(13)19/h1-8H,(H,20,21)
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n/an/a 180n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115424
PNG
(CHEMBL3608594)
Show SMILES Oc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C16H10ClFN2O2S/c17-11-4-2-1-3-10(11)15(22)14-8-19-16(23-14)20-13-6-5-9(21)7-12(13)18/h1-8,21H,(H,19,20)
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n/an/a 250n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115423
PNG
(CHEMBL3608595)
Show SMILES Fc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C16H10ClFN2OS/c17-13-4-2-1-3-12(13)15(21)14-9-19-16(22-14)20-11-7-5-10(18)6-8-11/h1-9H,(H,19,20)
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n/an/a 330n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115422
PNG
(CHEMBL3608596)
Show SMILES Nc1cccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)c1F
Show InChI InChI=1S/C16H11ClFN3OS/c17-10-5-2-1-4-9(10)15(22)13-8-20-16(23-13)21-12-7-3-6-11(19)14(12)18/h1-8H,19H2,(H,20,21)
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n/an/a 450n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115421
PNG
(CHEMBL3608597)
Show SMILES Clc1ccccc1C(=O)c1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C16H11ClN2OS/c17-13-9-5-4-8-12(13)15(20)14-10-18-16(21-14)19-11-6-2-1-3-7-11/h1-10H,(H,18,19)
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n/an/a 610n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115420
PNG
(CHEMBL3608598)
Show SMILES Fc1ccccc1Nc1ncc(s1)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C16H10ClFN2OS/c17-11-6-2-1-5-10(11)15(21)14-9-19-16(22-14)20-13-8-4-3-7-12(13)18/h1-9H,(H,19,20)
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n/an/a 790n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115419
PNG
(CHEMBL3608599)
Show SMILES Clc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C16H10Cl2N2OS/c17-10-5-7-11(8-6-10)20-16-19-9-14(22-16)15(21)12-3-1-2-4-13(12)18/h1-9H,(H,19,20)
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n/an/a 910n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115418
PNG
(CHEMBL3608600)
Show SMILES Clc1ccccc1C(=O)c1cnc(Nc2ccc(Br)cc2)s1
Show InChI InChI=1S/C16H10BrClN2OS/c17-10-5-7-11(8-6-10)20-16-19-9-14(22-16)15(21)12-3-1-2-4-13(12)18/h1-9H,(H,19,20)
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n/an/a 940n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115417
PNG
(CHEMBL3608601)
Show SMILES Brc1ccccc1C(=O)c1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C16H11BrN2OS/c17-13-9-5-4-8-12(13)15(20)14-10-18-16(21-14)19-11-6-2-1-3-7-11/h1-10H,(H,18,19)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115434
PNG
(CHEMBL3608592)
Show SMILES O=C(c1cnc(Nc2ccccc2)s1)c1ccccc1
Show InChI InChI=1S/C16H12N2OS/c19-15(12-7-3-1-4-8-12)14-11-17-16(20-14)18-13-9-5-2-6-10-13/h1-11H,(H,17,18)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115416
PNG
(CHEMBL3608977)
Show SMILES Clc1ccccc1C(=O)c1cnc(Nc2cccc(NC(=O)c3ccccc3)c2)s1
Show InChI InChI=1S/C23H16ClN3O2S/c24-19-12-5-4-11-18(19)21(28)20-14-25-23(30-20)27-17-10-6-9-16(13-17)26-22(29)15-7-2-1-3-8-15/h1-14H,(H,25,27)(H,26,29)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115415
PNG
(CHEMBL3608978)
Show SMILES COc1cccc(c1)C(=O)c1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C17H14N2O2S/c1-21-14-9-5-6-12(10-14)16(20)15-11-18-17(22-15)19-13-7-3-2-4-8-13/h2-11H,1H3,(H,18,19)
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n/an/a 1.23E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115414
PNG
(CHEMBL3608979)
Show SMILES Oc1cccc(c1)C(=O)c1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C16H12N2O2S/c19-13-8-4-5-11(9-13)15(20)14-10-17-16(21-14)18-12-6-2-1-3-7-12/h1-10,19H,(H,17,18)
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n/an/a 1.31E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115413
PNG
(CHEMBL3608980)
Show SMILES COc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C17H13ClN2O2S/c1-22-12-8-6-11(7-9-12)20-17-19-10-15(23-17)16(21)13-4-2-3-5-14(13)18/h2-10H,1H3,(H,19,20)
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n/an/a 1.44E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115412
PNG
(CHEMBL3608981)
Show SMILES [O-][N+](=O)c1cccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C16H10ClN3O3S/c17-13-7-2-1-6-12(13)15(21)14-9-18-16(24-14)19-10-4-3-5-11(8-10)20(22)23/h1-9H,(H,18,19)
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n/an/a 1.62E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115411
PNG
(CHEMBL3608982)
Show SMILES Fc1c(NC(=O)c2ccccc2)cccc1Nc1ncc(s1)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C23H15ClFN3O2S/c24-16-10-5-4-9-15(16)21(29)19-13-26-23(31-19)28-18-12-6-11-17(20(18)25)27-22(30)14-7-2-1-3-8-14/h1-13H,(H,26,28)(H,27,30)
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n/an/a 1.98E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115410
PNG
(CHEMBL3608983)
Show SMILES Oc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C16H11ClN2O2S/c17-13-4-2-1-3-12(13)15(21)14-9-18-16(22-14)19-10-5-7-11(20)8-6-10/h1-9,20H,(H,18,19)
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n/an/a 2.04E+3n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115409
PNG
(CHEMBL3608984)
Show SMILES [O-][N+](=O)c1cccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)c1F
Show InChI InChI=1S/C16H9ClFN3O3S/c17-10-5-2-1-4-9(10)15(22)13-8-19-16(25-13)20-11-6-3-7-12(14(11)18)21(23)24/h1-8H,(H,19,20)
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n/an/a 1.27E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115408
PNG
(CHEMBL3608985)
Show SMILES Nc1cccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)c1
Show InChI InChI=1S/C16H12ClN3OS/c17-13-7-2-1-6-12(13)15(21)14-9-19-16(22-14)20-11-5-3-4-10(18)8-11/h1-9H,18H2,(H,19,20)
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n/an/a 1.62E+4n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115407
PNG
(CHEMBL3608986)
Show SMILES Cc1ccccc1C(=O)c1cnc(Nc2ccccc2)s1
Show InChI InChI=1S/C17H14N2OS/c1-12-7-5-6-10-14(12)16(20)15-11-18-17(21-15)19-13-8-3-2-4-9-13/h2-11H,1H3,(H,18,19)
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n/an/a 1.16E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14


(Homo sapiens (Human))		BDBM50115406
PNG
(CHEMBL3608987)
Show SMILES Nc1ccc(Nc2ncc(s2)C(=O)c2ccccc2Cl)cc1
Show InChI InChI=1S/C16H12ClN3OS/c17-13-4-2-1-3-12(13)15(21)14-9-19-16(22-14)20-11-7-5-10(18)6-8-11/h1-9H,18H2,(H,19,20)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Sejong University

Curated by ChEMBL


Assay Description
Inhibition of p38 MAP kinase (unknown origin) by biochemical assay

Bioorg Med Chem Lett 25: 3784-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.094
BindingDB Entry DOI: 10.7270/Q2BC41BX
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%