Affinity Data by PubMed id=26280490

PubMed code 26280490

Found 17 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cathepsin K (Homo sapiens (Human))	BDBM19855 (Balicatib \| CHEMBL371064 \| N-[1-(cyanomethylcarbam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Cathepsin K (Homo sapiens (Human))	BDBM50114048 (CHEMBL3605410) Show SMILES Nc1cc(Br)ccc1C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cathepsin K (Homo sapiens (Human))	BDBM50114047 (CHEMBL3605409) Show SMILES Nc1cc(Cl)ccc1C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50114024 (CHEMBL3605413) Show SMILES Nc1ccc(cc1F)C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cathepsin K (Homo sapiens (Human))	BDBM50114027 (CHEMBL3605414) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	55	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50114023 (CHEMBL3605408) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50114050 (CHEMBL3605412) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin K (Homo sapiens (Human))	BDBM50114049 (CHEMBL3605411) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-K using Z-Gly-Pro-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM19855 (Balicatib \| CHEMBL371064 \| N-[1-(cyanomethylcarbam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	503	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50114024 (CHEMBL3605413) Show SMILES Nc1ccc(cc1F)C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50114027 (CHEMBL3605414) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-S using Z-Phe-Val-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50114049 (CHEMBL3605411) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50114023 (CHEMBL3605408) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-S using Z-Phe-Val-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50114024 (CHEMBL3605413) Show SMILES Nc1ccc(cc1F)C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-S using Z-Phe-Val-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50114047 (CHEMBL3605409) Show SMILES Nc1cc(Cl)ccc1C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50114048 (CHEMBL3605410) Show SMILES Nc1cc(Br)ccc1C(=O)NC1(CCCCC1)C(=O)NCC#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19855 (Balicatib \| CHEMBL371064 \| N-[1-(cyanomethylcarbam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	6.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Chemistry Curated by ChEMBL					Assay Description Inhibition of human cathepsin-S using Z-Phe-Val-Arg-AMC as substrate preincubated for 30 mins measured after 10 mins by fluorescence assay				J Med Chem 58: 6928-37 (2015) Article DOI: 10.1021/acs.jmedchem.5b00746 BindingDB Entry DOI: 10.7270/Q2BK1F44
National Institute of Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%