BindingDB logo
myBDB logout

PubMed code 26306982

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50120378
PNG
(CHEMBL3616709)
Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)NC1C2CC3CC(C2)CC1C3 |TLB:18:17:21:14.13.12,18:13:16.17.19:21,THB:12:13:16:19.20.21,12:20:16:14.18.13,11:12:16.17.19:21,(8.9,3.57,;7.81,3.01,;6.51,3.85,;6.58,5.08,;5.14,3.15,;5.06,1.61,;6.35,.77,;7.73,1.47,;8.76,.8,;3.69,.91,;3.62,-.32,;2.4,1.76,;1.01,1.05,;-.28,1.69,;-1.04,.44,;-1.04,-1.32,;-2.25,-2.11,;-1.85,-.7,;-2.02,.73,;-.4,-.88,;1.11,-.36,;.37,-1.59,)|
Show InChI InChI=1S/C17H20Cl2N2O/c18-13-6-12(7-14(19)15(13)20)17(22)21-16-10-2-8-1-9(4-10)5-11(16)3-8/h6-11,16H,1-5,20H2,(H,21,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human mixed sex human liver microsomes assessed as reduction in conversion of [3H]-cortisone to [3H]-cortisol pre-incuba...

Bioorg Med Chem Lett 25: 4250-3 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.097
BindingDB Entry DOI: 10.7270/Q2ZP47Z5
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50120377
PNG
(CHEMBL1889797)
Show SMILES O=C(NC1C2CC3CC(C2)CC1C3)C1CCCCC1 |TLB:12:11:9:6.5.7,THB:2:3:9:6.5.7,12:6:9:3.11.10,7:6:3:8.9.10,7:8:3:6.5.12,(2.95,-1.31,;1.47,-.87,;1.11,.62,;2.22,1.69,;3.59,2.39,;3.59,3.78,;4.43,5.26,;5.8,4.56,;5.8,3.16,;4.97,1.69,;4.43,2.47,;3.06,3.16,;3.06,4.56,;.35,-1.93,;.72,-3.43,;-.4,-4.49,;-1.87,-4.06,;-2.24,-2.56,;-1.12,-1.5,)|
Show InChI InChI=1S/C17H27NO/c19-17(13-4-2-1-3-5-13)18-16-14-7-11-6-12(9-14)10-15(16)8-11/h11-16H,1-10H2,(H,18,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 86n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human mixed sex human liver microsomes assessed as reduction in conversion of [3H]-cortisone to [3H]-cortisol pre-incuba...

Bioorg Med Chem Lett 25: 4250-3 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.097
BindingDB Entry DOI: 10.7270/Q2ZP47Z5
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50120379
PNG
(CHEMBL3616710)
Show SMILES O=C(NC1C2CC3CC(C2)CC1C3)C1CCCC1 |TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:3:4:7:10.11.12,3:11:7:5.9.4,2:3:7.8.10:12,(3.65,-.32,;3.72,.92,;2.42,1.77,;1.02,1.06,;-.29,1.71,;-1.05,.45,;-1.05,-1.34,;-2.27,-2.13,;-1.87,-.7,;-2.04,.73,;-.4,-.89,;1.12,-.36,;.37,-1.61,;5.11,1.62,;6.47,.91,;7.57,2.01,;6.86,3.39,;5.33,3.15,)|
Show InChI InChI=1S/C16H25NO/c18-16(12-3-1-2-4-12)17-15-13-6-10-5-11(8-13)9-14(15)7-10/h10-15H,1-9H2,(H,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 520n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human mixed sex human liver microsomes assessed as reduction in conversion of [3H]-cortisone to [3H]-cortisol pre-incuba...

Bioorg Med Chem Lett 25: 4250-3 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.097
BindingDB Entry DOI: 10.7270/Q2ZP47Z5
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))		BDBM50120376
PNG
(CHEMBL596815)
Show SMILES O=C(NC1C2CC3CC(C2)CC1C3)N1CCCCC1 |TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:3:4:7:10.11.12,3:11:7:5.9.4,2:3:7.8.10:12|
Show InChI InChI=1S/C16H26N2O/c19-16(18-4-2-1-3-5-18)17-15-13-7-11-6-12(9-13)10-14(15)8-11/h11-15H,1-10H2,(H,17,19)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 873n/an/an/an/an/an/a



Universitat de Barcelona

Curated by ChEMBL


Assay Description
Inhibition of 11beta-HSD1 in human mixed sex human liver microsomes assessed as reduction in conversion of [3H]-cortisone to [3H]-cortisol pre-incuba...

Bioorg Med Chem Lett 25: 4250-3 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.097
BindingDB Entry DOI: 10.7270/Q2ZP47Z5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%