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PubMed code 26310893

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nucleoprotein


(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)		BDBM50121537
PNG
(CHEMBL3616839)
Show SMILES Cc1onc(c1C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O)-c1ccccc1Cl
Show InChI InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)17-4-2-3-5-18(17)22)21(27)25-12-10-24(11-13-25)15-6-8-16(9-7-15)26(28)29/h2-9H,10-13H2,1H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Genomics Research Center

Curated by ChEMBL


Assay Description
Binding affinity to Influenza A virus (A/WSN/1933(H1N1)) nucleoprotein transfected in 293T cells assessed as inhibition of RNA dependent RNA polymera...

Eur J Med Chem 102: 477-86 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.016
BindingDB Entry DOI: 10.7270/Q2FJ2JK5
More data for this
Ligand-Target Pair
Nucleoprotein


(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)		BDBM50121537
PNG
(CHEMBL3616839)
Show SMILES Cc1onc(c1C(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O)-c1ccccc1Cl
Show InChI InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)17-4-2-3-5-18(17)22)21(27)25-12-10-24(11-13-25)15-6-8-16(9-7-15)26(28)29/h2-9H,10-13H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Genomics Research Center

Curated by ChEMBL


Assay Description
Binding affinity to Influenza A virus (A/WSN/1933(H1N1)) nucleoprotein S377G mutant transfected in 293T cells assessed as inhibition of RNA dependent...

Eur J Med Chem 102: 477-86 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.016
BindingDB Entry DOI: 10.7270/Q2FJ2JK5
More data for this
Ligand-Target Pair
Nucleoprotein


(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)		BDBM50121392
PNG
(CHEMBL3616822)
Show SMILES Cn1c2c3C(OCC(C)(C)n3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1ccccc1F
Show InChI InChI=1S/C25H24FN3O3/c1-25(2)14-32-22(16-12-8-9-13-17(16)26)21-20-18(23(30)28(4)24(31)27(20)3)19(29(21)25)15-10-6-5-7-11-15/h5-13,22H,14H2,1-4H3
PDB

UniProtKB/SwissProt

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PC sid
UniChem
Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Genomics Research Center

Curated by ChEMBL


Assay Description
Binding affinity to Influenza A virus (A/WSN/1933(H1N1)) nucleoprotein S377G mutant transfected in 293T cells assessed as inhibition of RNA dependent...

Eur J Med Chem 102: 477-86 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.016
BindingDB Entry DOI: 10.7270/Q2FJ2JK5
More data for this
Ligand-Target Pair
Nucleoprotein


(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)		BDBM50121392
PNG
(CHEMBL3616822)
Show SMILES Cn1c2c3C(OCC(C)(C)n3c(-c3ccccc3)c2c(=O)n(C)c1=O)c1ccccc1F
Show InChI InChI=1S/C25H24FN3O3/c1-25(2)14-32-22(16-12-8-9-13-17(16)26)21-20-18(23(30)28(4)24(31)27(20)3)19(29(21)25)15-10-6-5-7-11-15/h5-13,22H,14H2,1-4H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.90E+3n/an/an/an/an/an/a



Genomics Research Center

Curated by ChEMBL


Assay Description
Binding affinity to Influenza A virus (A/WSN/1933(H1N1)) nucleoprotein transfected in 293T cells assessed as inhibition of RNA dependent RNA polymera...

Eur J Med Chem 102: 477-86 (2015)


Article DOI: 10.1016/j.ejmech.2015.08.016
BindingDB Entry DOI: 10.7270/Q2FJ2JK5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%