Found 13 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498799
(Manassantin A | Manassantin B1)Show SMILES COc1ccc(cc1OC)[C@@H](O)[C@@H](C)Oc1ccc(cc1O)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1 |r| Show InChI InChI=1S/C41H50O11/c1-22-23(2)41(29-13-17-34(37(21-29)49-9)51-25(4)39(44)27-11-16-33(46-6)36(20-27)48-8)52-40(22)28-12-14-31(30(42)18-28)50-24(3)38(43)26-10-15-32(45-5)35(19-26)47-7/h10-25,38-44H,1-9H3/t22-,23-,24-,25-,38+,39+,40+,41+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498797
(CHEMBL3105545)Show SMILES COc1ccc(cc1OC)[C@@H](O)[C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C32H40O8/c1-18-19(2)32(40-31(18)22-10-13-25(35-5)28(16-22)37-7)23-11-14-26(29(17-23)38-8)39-20(3)30(33)21-9-12-24(34-4)27(15-21)36-6/h9-20,30-33H,1-8H3/t18-,19-,20-,30+,31+,32+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498805
(CHEMBL3623807)Show SMILES COc1ccc(cc1OC)C(=O)COc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(OCC(=O)c2ccc(OC)c(OC)c2)c(OC)c1 |r| Show InChI InChI=1S/C40H44O11/c1-23-24(2)40(28-12-16-34(38(20-28)48-8)50-22-30(42)26-10-14-32(44-4)36(18-26)46-6)51-39(23)27-11-15-33(37(19-27)47-7)49-21-29(41)25-9-13-31(43-3)35(17-25)45-5/h9-20,23-24,39-40H,21-22H2,1-8H3/t23-,24-,39+,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498796
(CHEMBL3623808)Show SMILES COc1ccc(cc1OC)[C@@H](O)COc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(OC[C@H](O)c2ccc(OC)c(OC)c2)c(OC)c1 |r| Show InChI InChI=1S/C40H48O11/c1-23-24(2)40(28-12-16-34(38(20-28)48-8)50-22-30(42)26-10-14-32(44-4)36(18-26)46-6)51-39(23)27-11-15-33(37(19-27)47-7)49-21-29(41)25-9-13-31(43-3)35(17-25)45-5/h9-20,23-24,29-30,39-42H,21-22H2,1-8H3/t23-,24-,29+,30+,39+,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498801
(CHEMBL3623806)Show SMILES CO[C@@H]([C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](OC)c2ccc(OC)c(OC)c2)c(OC)c1)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C44H56O11/c1-25-26(2)42(30-16-20-36(40(22-30)50-10)54-28(4)44(52-12)32-14-18-34(46-6)38(24-32)48-8)55-41(25)29-15-19-35(39(21-29)49-9)53-27(3)43(51-11)31-13-17-33(45-5)37(23-31)47-7/h13-28,41-44H,1-12H3/t25-,26-,27-,28-,41+,42+,43+,44+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498794
(CHEMBL3623812)Show SMILES COc1cc(ccc1O[C@H](C)[C@H](O)c1ccccc1)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)[C@H](O)c2ccccc2)c(OC)c1 |r| Show InChI InChI=1S/C38H44O7/c1-23-24(2)38(30-18-20-32(34(22-30)42-6)44-26(4)36(40)28-15-11-8-12-16-28)45-37(23)29-17-19-31(33(21-29)41-5)43-25(3)35(39)27-13-9-7-10-14-27/h7-26,35-40H,1-6H3/t23-,24-,25-,26-,35+,36+,37+,38+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498800
(CHEMBL3623811)Show SMILES COc1cc(ccc1O[C@H](C)C(=O)c1ccccc1)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)C(=O)c2ccccc2)c(OC)c1 |r| Show InChI InChI=1S/C38H40O7/c1-23-24(2)38(30-18-20-32(34(22-30)42-6)44-26(4)36(40)28-15-11-8-12-16-28)45-37(23)29-17-19-31(33(21-29)41-5)43-25(3)35(39)27-13-9-7-10-14-27/h7-26,37-38H,1-6H3/t23-,24-,25-,26-,37+,38+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498804
(CHEMBL3623805)Show SMILES COc1ccc(cc1OC)C(=O)[C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)C(=O)c2ccc(OC)c(OC)c2)c(OC)c1 |r| Show InChI InChI=1S/C42H48O11/c1-23-24(2)42(30-14-18-34(38(22-30)50-10)52-26(4)40(44)28-12-16-32(46-6)36(20-28)48-8)53-41(23)29-13-17-33(37(21-29)49-9)51-25(3)39(43)27-11-15-31(45-5)35(19-27)47-7/h11-26,41-42H,1-10H3/t23-,24-,25-,26-,41+,42+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498803
(CHEMBL3623810)Show SMILES COc1ccc(CCOc2ccc(cc2OC)[C@H]2O[C@@H]([C@H](C)[C@H]2C)c2ccc(OCCc3ccc(OC)c(OC)c3)c(OC)c2)cc1OC |r| Show InChI InChI=1S/C40H48O9/c1-25-26(2)40(30-12-16-34(38(24-30)46-8)48-20-18-28-10-14-32(42-4)36(22-28)44-6)49-39(25)29-11-15-33(37(23-29)45-7)47-19-17-27-9-13-31(41-3)35(21-27)43-5/h9-16,21-26,39-40H,17-20H2,1-8H3/t25-,26-,39+,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498795
(CHEMBL3623809)Show SMILES CO[C@@H](COc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(OC[C@H](OC)c2ccc(OC)c(OC)c2)c(OC)c1)c1ccc(OC)c(OC)c1 |r| Show InChI InChI=1S/C42H52O11/c1-25-26(2)42(30-14-18-34(38(22-30)48-8)52-24-40(50-10)28-12-16-32(44-4)36(20-28)46-6)53-41(25)29-13-17-33(37(21-29)47-7)51-23-39(49-9)27-11-15-31(43-3)35(19-27)45-5/h11-22,25-26,39-42H,23-24H2,1-10H3/t25-,26-,39+,40+,41+,42+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498793
(CHEMBL3623803)Show SMILES COc1ccc(cc1O)C(=O)[C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)C(=O)c2ccc(OC)c(O)c2)c(OC)c1 |r| Show InChI InChI=1S/C40H44O11/c1-21-22(2)40(28-12-16-34(36(20-28)48-8)50-24(4)38(44)26-10-14-32(46-6)30(42)18-26)51-39(21)27-11-15-33(35(19-27)47-7)49-23(3)37(43)25-9-13-31(45-5)29(41)17-25/h9-24,39-42H,1-8H3/t21-,22-,23-,24-,39+,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498802
(CHEMBL3621232)Show SMILES COc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)C(=O)c2ccc(OC)c(OC)c2)c(OC)c1 |r| Show InChI InChI=1S/C32H38O8/c1-18-19(2)32(40-31(18)22-10-13-25(35-5)28(16-22)37-7)23-11-14-26(29(17-23)38-8)39-20(3)30(33)21-9-12-24(34-4)27(15-21)36-6/h9-20,31-32H,1-8H3/t18-,19-,20-,31+,32+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50498798
(CHEMBL3623804)Show SMILES COc1ccc(cc1OC)C(=O)COc1cc(ccc1OC)C(=O)[C@@H](C)Oc1ccc(cc1OC)[C@H]1O[C@@H]([C@H](C)[C@H]1C)c1ccc(O[C@H](C)C(=O)c2ccc(OC)c(OCC(=O)c3ccc(OC)c(OC)c3)c2)c(OC)c1 |r| Show InChI InChI=1S/C60H64O17/c1-33-34(2)60(42-18-24-50(54(30-42)72-12)76-36(4)58(64)40-16-22-48(68-8)56(28-40)74-32-44(62)38-14-20-46(66-6)52(26-38)70-10)77-59(33)41-17-23-49(53(29-41)71-11)75-35(3)57(63)39-15-21-47(67-7)55(27-39)73-31-43(61)37-13-19-45(65-5)51(25-37)69-9/h13-30,33-36,59-60H,31-32H2,1-12H3/t33-,34-,35-,36-,59+,60+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by ChEMBL
| Assay Description Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assay |
J Med Chem 58: 7659-71 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01220 BindingDB Entry DOI: 10.7270/Q2T156N9 |
More data for this Ligand-Target Pair | |