Affinity Data by PubMed id=26433631

PubMed code 26433631

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Squalene synthase (Rattus norvegicus)	BDBM50125785 (CHEMBL3623842) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...				Bioorg Med Chem 23: 7015-23 (2015) Article DOI: 10.1016/j.bmc.2015.09.034 BindingDB Entry DOI: 10.7270/Q2SJ1NFB
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Squalene synthase (Rattus norvegicus)	BDBM50125784 (CHEMBL3623843) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...				Bioorg Med Chem 23: 7015-23 (2015) Article DOI: 10.1016/j.bmc.2015.09.034 BindingDB Entry DOI: 10.7270/Q2SJ1NFB
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Squalene synthase (Rattus norvegicus)	BDBM50125786 (CHEMBL3623841) Show SMILES Br.CN1CCOC(O)(C1)c1ccc2c(ccc3ccccc23)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...				Bioorg Med Chem 23: 7015-23 (2015) Article DOI: 10.1016/j.bmc.2015.09.034 BindingDB Entry DOI: 10.7270/Q2SJ1NFB
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Squalene synthase (Rattus norvegicus)	BDBM50125787 (CHEMBL3623679) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...				Bioorg Med Chem 23: 7015-23 (2015) Article DOI: 10.1016/j.bmc.2015.09.034 BindingDB Entry DOI: 10.7270/Q2SJ1NFB
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Squalene synthase (Rattus norvegicus)	BDBM50125788 (CHEMBL3623678) Show SMILES Br.OC1(CN2CCCCC2CO1)c1ccc(cc1)C1CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...				Bioorg Med Chem 23: 7015-23 (2015) Article DOI: 10.1016/j.bmc.2015.09.034 BindingDB Entry DOI: 10.7270/Q2SJ1NFB
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Squalene synthase (Rattus norvegicus)	BDBM50125789 (CHEMBL3623677) Show SMILES Br.CN1CCOC(O)(C1)c1ccc(cc1)C1CCCCC1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 3...				Bioorg Med Chem 23: 7015-23 (2015) Article DOI: 10.1016/j.bmc.2015.09.034 BindingDB Entry DOI: 10.7270/Q2SJ1NFB
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%