Affinity Data by PubMed id=26435512

PubMed code 26435512

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50375592 (CHEMBL412272) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	680	n/a	n/a	n/a	n/a
Heinrich Heine University Curated by ChEMBL					Assay Description Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...				Eur J Med Chem 104: 57-72 (2015) Article DOI: 10.1016/j.ejmech.2015.09.024 BindingDB Entry DOI: 10.7270/Q2S185GG
Heinrich Heine University Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50375595 (CHEMBL185878 \| Taurochenodeoxycholate) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.96E+4	n/a	n/a	n/a	n/a
Heinrich Heine University Curated by ChEMBL					Assay Description Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...				Eur J Med Chem 104: 57-72 (2015) Article DOI: 10.1016/j.ejmech.2015.09.024 BindingDB Entry DOI: 10.7270/Q2S185GG
Heinrich Heine University Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50236230 (2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dih...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	5.05E+4	n/a	n/a	n/a	n/a
Heinrich Heine University Curated by ChEMBL					Assay Description Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...				Eur J Med Chem 104: 57-72 (2015) Article DOI: 10.1016/j.ejmech.2015.09.024 BindingDB Entry DOI: 10.7270/Q2S185GG
Heinrich Heine University Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50375592 (CHEMBL412272) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a
Heinrich Heine University Curated by ChEMBL					Assay Description Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...				Eur J Med Chem 104: 57-72 (2015) Article DOI: 10.1016/j.ejmech.2015.09.024 BindingDB Entry DOI: 10.7270/Q2S185GG
Heinrich Heine University Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50236230 (2-((R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dih...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.05E+5	n/a	n/a	n/a	n/a
Heinrich Heine University Curated by ChEMBL					Assay Description Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase ...				Eur J Med Chem 104: 57-72 (2015) Article DOI: 10.1016/j.ejmech.2015.09.024 BindingDB Entry DOI: 10.7270/Q2S185GG
Heinrich Heine University Curated by ChEMBL					More data for this Ligand-Target Pair
G-protein coupled bile acid receptor 1 (Homo sapiens (Human))	BDBM50375595 (CHEMBL185878 \| Taurochenodeoxycholate) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
Heinrich Heine University Curated by ChEMBL					Assay Description Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase re...				Eur J Med Chem 104: 57-72 (2015) Article DOI: 10.1016/j.ejmech.2015.09.024 BindingDB Entry DOI: 10.7270/Q2S185GG
Heinrich Heine University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%