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PubMed code 26442778

Compile data set for download or QSAR
Found 15 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128515
PNG
(CHEMBL3629610)
Show SMILES COc1ccc-2c(c1)C(=O)c1c-2c(=O)c2ccccc2n1C
Show InChI InChI=1S/C18H13NO3/c1-19-14-6-4-3-5-12(14)17(20)15-11-8-7-10(22-2)9-13(11)18(21)16(15)19/h3-9H,1-2H3
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n/an/a 6.60E+3n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM50128509
PNG
(CHEMBL3629616)
Show SMILES O=C1c2ccccc2-c2c1oc1ccccc1c2=O
Show InChI InChI=1S/C16H8O3/c17-14-11-7-3-4-8-12(11)19-16-13(14)9-5-1-2-6-10(9)15(16)18/h1-8H
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NCI pathway
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n/an/a 8.97E+3n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of PLK3 (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128512
PNG
(CHEMBL3629613)
Show SMILES O=C1c2ccccc2-c2c1n(Cc1ccccc1)c1ccccc1c2=O
Show InChI InChI=1S/C23H15NO2/c25-22-18-12-6-7-13-19(18)24(14-15-8-2-1-3-9-15)21-20(22)16-10-4-5-11-17(16)23(21)26/h1-13H,14H2
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n/an/a 1.03E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128514
PNG
(CHEMBL3629611)
Show SMILES COc1ccc2C(=O)c3c(-c2c1)c(=O)c1ccccc1n3C
Show InChI InChI=1S/C18H13NO3/c1-19-14-6-4-3-5-12(14)17(20)15-13-9-10(22-2)7-8-11(13)18(21)16(15)19/h3-9H,1-2H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128510
PNG
(CHEMBL3629615)
Show SMILES COc1ccc-2c(c1)C(=O)c1c-2c(=O)c2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C24H17NO3/c1-28-16-11-12-17-19(13-16)24(27)22-21(17)23(26)18-9-5-6-10-20(18)25(22)14-15-7-3-2-4-8-15/h2-13H,14H2,1H3
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n/an/a 1.64E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128511
PNG
(CHEMBL3629614)
Show SMILES CCOC(=O)n1c2C(=O)c3ccccc3-c2c(=O)c2ccccc12
Show InChI InChI=1S/C19H13NO4/c1-2-24-19(23)20-14-10-6-5-9-13(14)17(21)15-11-7-3-4-8-12(11)18(22)16(15)20/h3-10H,2H2,1H3
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n/an/a 1.65E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128520
PNG
(CHEMBL3629605)
Show SMILES Cn1c2C(=O)c3ccccc3-c2c(=O)c2ccccc12
Show InChI InChI=1S/C17H11NO2/c1-18-13-9-5-4-8-12(13)16(19)14-10-6-2-3-7-11(10)17(20)15(14)18/h2-9H,1H3
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n/an/a 2.89E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128517
PNG
(CHEMBL3629608)
Show SMILES Cc1ccc-2c(c1)C(=O)c1c-2c(=O)c2ccccc2n1C
Show InChI InChI=1S/C18H13NO2/c1-10-7-8-11-13(9-10)18(21)16-15(11)17(20)12-5-3-4-6-14(12)19(16)2/h3-9H,1-2H3
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n/an/a 4.72E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128509
PNG
(CHEMBL3629616)
Show SMILES O=C1c2ccccc2-c2c1oc1ccccc1c2=O
Show InChI InChI=1S/C16H8O3/c17-14-11-7-3-4-8-12(11)19-16-13(14)9-5-1-2-6-10(9)15(16)18/h1-8H
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n/an/a 5.58E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128518
PNG
(CHEMBL3629607)
Show SMILES Cc1cccc-2c1C(=O)c1c-2c(=O)c2ccccc2n1C
Show InChI InChI=1S/C18H13NO2/c1-10-6-5-8-12-14(10)18(21)16-15(12)17(20)11-7-3-4-9-13(11)19(16)2/h3-9H,1-2H3
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n/an/a 7.33E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128519
PNG
(CHEMBL3629604)
Show SMILES Cn1c2C(=O)c3ccccc3-c2c(=O)c2ccc(Cl)cc12
Show InChI InChI=1S/C17H10ClNO2/c1-19-13-8-9(18)6-7-12(13)16(20)14-10-4-2-3-5-11(10)17(21)15(14)19/h2-8H,1H3
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n/an/a 8.85E+4n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128521
PNG
(CHEMBL3629606)
Show SMILES Cn1c2C(=O)c3ccccc3-c2c(=O)c2ccc(cc12)C(F)(F)F
Show InChI InChI=1S/C18H10F3NO2/c1-22-13-8-9(18(19,20)21)6-7-12(13)16(23)14-10-4-2-3-5-11(10)17(24)15(14)22/h2-8H,1H3
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n/an/a 1.17E+5n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128516
PNG
(CHEMBL3629609)
Show SMILES Cn1c2C(=O)c3c(cccc3O)-c2c(=O)c2ccccc12
Show InChI InChI=1S/C17H11NO3/c1-18-11-7-3-2-5-9(11)16(20)14-10-6-4-8-12(19)13(10)17(21)15(14)18/h2-8,19H,1H3
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n/an/a 1.41E+5n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))		BDBM50128520
PNG
(CHEMBL3629605)
Show SMILES Cn1c2C(=O)c3ccccc3-c2c(=O)c2ccccc12
Show InChI InChI=1S/C17H11NO2/c1-18-13-9-5-4-8-12(13)16(19)14-10-6-2-3-7-11(10)17(20)15(14)18/h2-9H,1H3
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n/an/a>2.00E+5n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of PLK3 (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50128513
PNG
(CHEMBL3629612)
Show SMILES COc1cccc2C(=O)c3c(-c12)c(=O)c1ccccc1n3C
Show InChI InChI=1S/C18H13NO3/c1-19-12-8-4-3-6-10(12)17(20)15-14-11(18(21)16(15)19)7-5-9-13(14)22-2/h3-9H,1-2H3
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n/an/a 2.09E+5n/an/an/an/an/an/a



Institute for Basic Science (IBS)

Curated by ChEMBL


Assay Description
Inhibition of TrkA (unknown origin) by radiometric analysis in presence of [gamma-33P]-ATP

Bioorg Med Chem Lett 25: 5186-9 (2015)


Article DOI: 10.1016/j.bmcl.2015.09.070
BindingDB Entry DOI: 10.7270/Q2KP840G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%