Found 34 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499259
(CHEMBL3734939)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C23H20N2O4S/c1-30(28,29)20-13-9-16(10-14-20)21-15-22(17-5-3-2-4-6-17)25(24-21)19-11-7-18(8-12-19)23(26)27/h2-14,22H,15H2,1H3,(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499266
(CHEMBL3735601)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1cccs1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C21H18N2O4S2/c1-29(26,27)17-10-6-14(7-11-17)18-13-19(20-3-2-12-28-20)23(22-18)16-8-4-15(5-9-16)21(24)25/h2-12,19H,13H2,1H3,(H,24,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499272
(CHEMBL3735534)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C22H21N3O4S2/c1-30(26,27)19-11-7-16(8-12-19)21-15-22(17-5-3-2-4-6-17)25(24-21)18-9-13-20(14-10-18)31(23,28)29/h2-14,22H,15H2,1H3,(H2,23,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499273
(CHEMBL3735352)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1cccs1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C20H19N3O4S3/c1-29(24,25)16-8-4-14(5-9-16)18-13-19(20-3-2-12-28-20)23(22-18)15-6-10-17(11-7-15)30(21,26)27/h2-12,19H,13H2,1H3,(H2,21,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499263
(CHEMBL3735002)Show SMILES COc1cccc(c1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C23H23N3O5S2/c1-31-19-5-3-4-17(14-19)23-15-22(16-6-10-20(11-7-16)32(2,27)28)25-26(23)18-8-12-21(13-9-18)33(24,29)30/h3-14,23H,15H2,1-2H3,(H2,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499274
(CHEMBL3736416)Show SMILES COc1ccc(cc1OC)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:13| Show InChI InChI=1S/C24H25N3O6S2/c1-32-23-13-6-17(14-24(23)33-2)22-15-21(16-4-9-19(10-5-16)34(3,28)29)26-27(22)18-7-11-20(12-8-18)35(25,30)31/h4-14,22H,15H2,1-3H3,(H2,25,30,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499261
(CHEMBL3736140)Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C23H23N3O5S2/c1-31-19-9-3-17(4-10-19)23-15-22(16-5-11-20(12-6-16)32(2,27)28)25-26(23)18-7-13-21(14-8-18)33(24,29)30/h3-14,23H,15H2,1-2H3,(H2,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499271
(CHEMBL3736245)Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C24H22N2O5S/c1-31-20-11-5-17(6-12-20)23-15-22(16-7-13-21(14-8-16)32(2,29)30)25-26(23)19-9-3-18(4-10-19)24(27)28/h3-14,23H,15H2,1-2H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499267
(CHEMBL3735721)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C22H20ClN3O4S2/c1-31(27,28)19-10-4-15(5-11-19)21-14-22(16-2-6-17(23)7-3-16)26(25-21)18-8-12-20(13-9-18)32(24,29)30/h2-13,22H,14H2,1H3,(H2,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499262
(CHEMBL3736014)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C23H19FN2O4S/c1-31(29,30)20-12-6-15(7-13-20)21-14-22(16-2-8-18(24)9-3-16)26(25-21)19-10-4-17(5-11-19)23(27)28/h2-13,22H,14H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499270
(CHEMBL3735457)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C22H20FN3O4S2/c1-31(27,28)19-10-4-15(5-11-19)21-14-22(16-2-6-17(23)7-3-16)26(25-21)18-8-12-20(13-9-18)32(24,29)30/h2-13,22H,14H2,1H3,(H2,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499265
(CHEMBL3735490)Show SMILES COc1ccc(cc1OC)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:13| Show InChI InChI=1S/C25H24N2O6S/c1-32-23-13-8-18(14-24(23)33-2)22-15-21(16-6-11-20(12-7-16)34(3,30)31)26-27(22)19-9-4-17(5-10-19)25(28)29/h4-14,22H,15H2,1-3H3,(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.74E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499269
(CHEMBL3735888)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C23H19ClN2O4S/c1-31(29,30)20-12-6-15(7-13-20)21-14-22(16-2-8-18(24)9-3-16)26(25-21)19-10-4-17(5-11-19)23(27)28/h2-13,22H,14H2,1H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499268
(CHEMBL3735929)Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:15| Show InChI InChI=1S/C25H27N3O7S2/c1-33-23-13-17(14-24(34-2)25(23)35-3)22-15-21(16-5-9-19(10-6-16)36(4,29)30)27-28(22)18-7-11-20(12-8-18)37(26,31)32/h5-14,22H,15H2,1-4H3,(H2,26,31,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499266
(CHEMBL3735601)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1cccs1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C21H18N2O4S2/c1-29(26,27)17-10-6-14(7-11-17)18-13-19(20-3-2-12-28-20)23(22-18)16-8-4-15(5-9-16)21(24)25/h2-12,19H,13H2,1H3,(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499264
(CHEMBL3734866)Show SMILES COc1cccc(c1)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C24H22N2O5S/c1-31-20-5-3-4-18(14-20)23-15-22(16-8-12-21(13-9-16)32(2,29)30)25-26(23)19-10-6-17(7-11-19)24(27)28/h3-14,23H,15H2,1-2H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499259
(CHEMBL3734939)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C23H20N2O4S/c1-30(28,29)20-13-9-16(10-14-20)21-15-22(17-5-3-2-4-6-17)25(24-21)19-11-7-18(8-12-19)23(26)27/h2-14,22H,15H2,1H3,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499272
(CHEMBL3735534)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccccc1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C22H21N3O4S2/c1-30(26,27)19-11-7-16(8-12-19)21-15-22(17-5-3-2-4-6-17)25(24-21)18-9-13-20(14-10-18)31(23,28)29/h2-14,22H,15H2,1H3,(H2,23,28,29) | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM50499260
(CHEMBL3735808)Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:15| Show InChI InChI=1S/C26H26N2O7S/c1-33-23-13-18(14-24(34-2)25(23)35-3)22-15-21(16-7-11-20(12-8-16)36(4,31)32)27-28(22)19-9-5-17(6-10-19)26(29)30/h5-14,22H,15H2,1-4H3,(H,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499273
(CHEMBL3735352)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1cccs1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C20H19N3O4S3/c1-29(24,25)16-8-4-14(5-9-16)18-13-19(20-3-2-12-28-20)23(22-18)15-6-10-17(11-7-15)30(21,26)27/h2-12,19H,13H2,1H3,(H2,21,26,27) | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499261
(CHEMBL3736140)Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C23H23N3O5S2/c1-31-19-9-3-17(4-10-19)23-15-22(16-5-11-20(12-6-16)32(2,27)28)25-26(23)18-7-13-21(14-8-18)33(24,29)30/h3-14,23H,15H2,1-2H3,(H2,24,29,30) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499271
(CHEMBL3736245)Show SMILES COc1ccc(cc1)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C24H22N2O5S/c1-31-20-11-5-17(6-12-20)23-15-22(16-7-13-21(14-8-16)32(2,29)30)25-26(23)19-9-3-18(4-10-19)24(27)28/h3-14,23H,15H2,1-2H3,(H,27,28) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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PC cid
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PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499263
(CHEMBL3735002)Show SMILES COc1cccc(c1)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C23H23N3O5S2/c1-31-19-5-3-4-17(14-19)23-15-22(16-6-10-20(11-7-16)32(2,27)28)25-26(23)18-8-12-21(13-9-18)33(24,29)30/h3-14,23H,15H2,1-2H3,(H2,24,29,30) | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499267
(CHEMBL3735721)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C22H20ClN3O4S2/c1-31(27,28)19-10-4-15(5-11-19)21-14-22(16-2-6-17(23)7-3-16)26(25-21)18-8-12-20(13-9-18)32(24,29)30/h2-13,22H,14H2,1H3,(H2,24,29,30) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499274
(CHEMBL3736416)Show SMILES COc1ccc(cc1OC)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:13| Show InChI InChI=1S/C24H25N3O6S2/c1-32-23-13-6-17(14-24(23)33-2)22-15-21(16-4-9-19(10-5-16)34(3,28)29)26-27(22)18-7-11-20(12-8-18)35(25,30)31/h4-14,22H,15H2,1-3H3,(H2,25,30,31) | PDB
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499262
(CHEMBL3736014)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C23H19FN2O4S/c1-31(29,30)20-12-6-15(7-13-20)21-14-22(16-2-8-18(24)9-3-16)26(25-21)19-10-4-17(5-11-19)23(27)28/h2-13,22H,14H2,1H3,(H,27,28) | PDB
KEGG
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499270
(CHEMBL3735457)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(F)cc1)c1ccc(cc1)S(N)(=O)=O |t:11| Show InChI InChI=1S/C22H20FN3O4S2/c1-31(27,28)19-10-4-15(5-11-19)21-14-22(16-2-6-17(23)7-3-16)26(25-21)18-8-12-20(13-9-18)32(24,29)30/h2-13,22H,14H2,1H3,(H2,24,29,30) | PDB
KEGG
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499265
(CHEMBL3735490)Show SMILES COc1ccc(cc1OC)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:13| Show InChI InChI=1S/C25H24N2O6S/c1-32-23-13-8-18(14-24(23)33-2)22-15-21(16-6-11-20(12-7-16)34(3,30)31)26-27(22)19-9-4-17(5-10-19)25(28)29/h4-14,22H,15H2,1-3H3,(H,28,29) | PDB
KEGG
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499264
(CHEMBL3734866)Show SMILES COc1cccc(c1)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:11| Show InChI InChI=1S/C24H22N2O5S/c1-31-20-5-3-4-18(14-20)23-15-22(16-8-12-21(13-9-16)32(2,29)30)25-26(23)19-10-6-17(7-11-19)24(27)28/h3-14,23H,15H2,1-2H3,(H,27,28) | PDB
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GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499269
(CHEMBL3735888)Show SMILES CS(=O)(=O)c1ccc(cc1)C1=NN(C(C1)c1ccc(Cl)cc1)c1ccc(cc1)C(O)=O |t:11| Show InChI InChI=1S/C23H19ClN2O4S/c1-31(29,30)20-12-6-15(7-13-20)21-14-22(16-2-8-18(24)9-3-16)26(25-21)19-10-4-17(5-11-19)23(27)28/h2-13,22H,14H2,1H3,(H,27,28) | PDB
KEGG
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B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499268
(CHEMBL3735929)Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1c1ccc(cc1)S(N)(=O)=O)c1ccc(cc1)S(C)(=O)=O |c:15| Show InChI InChI=1S/C25H27N3O7S2/c1-33-23-13-17(14-24(34-2)25(23)35-3)22-15-21(16-5-9-19(10-6-16)36(4,29)30)27-28(22)18-7-11-20(12-8-18)37(26,31)32/h5-14,22H,15H2,1-4H3,(H2,26,31,32) | PDB
KEGG
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50499260
(CHEMBL3735808)Show SMILES COc1cc(cc(OC)c1OC)C1CC(=NN1c1ccc(cc1)C(O)=O)c1ccc(cc1)S(C)(=O)=O |c:15| Show InChI InChI=1S/C26H26N2O7S/c1-33-23-13-18(14-24(34-2)25(23)35-3)22-15-21(16-7-11-20(12-8-16)36(4,31)32)27-28(22)19-9-5-17(6-10-19)26(29)30/h5-14,22H,15H2,1-4H3,(H,29,30) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Beni-Suef University
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay |
Bioorg Med Chem Lett 25: 5787-91 (2015)
Article DOI: 10.1016/j.bmcl.2015.10.047
BindingDB Entry DOI: 10.7270/Q2P2724S |
More data for this
Ligand-Target Pair | |
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