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PubMed code 26599352

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 4 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 1 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 4 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
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n/an/a 580n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500590
PNG
(CHEMBL3754655)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C54H76N14O10/c1-3-4-18-38(61-32(2)69)47(72)66-42-30-45(70)58-24-11-10-20-37(46(55)71)62-50(75)41(29-34-31-60-36-19-9-8-17-35(34)36)64-48(73)39(21-12-25-59-54(56)57)63-49(74)40(28-33-15-6-5-7-16-33)65-51(76)43-22-13-26-67(43)53(78)44-23-14-27-68(44)52(42)77/h5-9,15-17,19,31,37-44,60H,3-4,10-14,18,20-30H2,1-2H3,(H2,55,71)(H,58,70)(H,61,69)(H,62,75)(H,63,74)(H,64,73)(H,65,76)(H,66,72)(H4,56,57,59)/t37-,38-,39-,40+,41-,42-,43-,44-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
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KEGG

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n/an/a 950n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 4 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 5 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 4 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500590
PNG
(CHEMBL3754655)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C54H76N14O10/c1-3-4-18-38(61-32(2)69)47(72)66-42-30-45(70)58-24-11-10-20-37(46(55)71)62-50(75)41(29-34-31-60-36-19-9-8-17-35(34)36)64-48(73)39(21-12-25-59-54(56)57)63-49(74)40(28-33-15-6-5-7-16-33)65-51(76)43-22-13-26-67(43)53(78)44-23-14-27-68(44)52(42)77/h5-9,15-17,19,31,37-44,60H,3-4,10-14,18,20-30H2,1-2H3,(H2,55,71)(H,58,70)(H,61,69)(H,62,75)(H,63,74)(H,64,73)(H,65,76)(H,66,72)(H4,56,57,59)/t37-,38-,39-,40+,41-,42-,43-,44-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 4 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500590
PNG
(CHEMBL3754655)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C54H76N14O10/c1-3-4-18-38(61-32(2)69)47(72)66-42-30-45(70)58-24-11-10-20-37(46(55)71)62-50(75)41(29-34-31-60-36-19-9-8-17-35(34)36)64-48(73)39(21-12-25-59-54(56)57)63-49(74)40(28-33-15-6-5-7-16-33)65-51(76)43-22-13-26-67(43)53(78)44-23-14-27-68(44)52(42)77/h5-9,15-17,19,31,37-44,60H,3-4,10-14,18,20-30H2,1-2H3,(H2,55,71)(H,58,70)(H,61,69)(H,62,75)(H,63,74)(H,64,73)(H,65,76)(H,66,72)(H4,56,57,59)/t37-,38-,39-,40+,41-,42-,43-,44-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 1 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 1 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 1 receptor expressed in HEK293 cells incubated for 40 mins by gamma count...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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n/an/an/an/a 1.80n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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n/an/an/an/a 1.80n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500590
PNG
(CHEMBL3754655)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C54H76N14O10/c1-3-4-18-38(61-32(2)69)47(72)66-42-30-45(70)58-24-11-10-20-37(46(55)71)62-50(75)41(29-34-31-60-36-19-9-8-17-35(34)36)64-48(73)39(21-12-25-59-54(56)57)63-49(74)40(28-33-15-6-5-7-16-33)65-51(76)43-22-13-26-67(43)53(78)44-23-14-27-68(44)52(42)77/h5-9,15-17,19,31,37-44,60H,3-4,10-14,18,20-30H2,1-2H3,(H2,55,71)(H,58,70)(H,61,69)(H,62,75)(H,63,74)(H,64,73)(H,65,76)(H,66,72)(H4,56,57,59)/t37-,38-,39-,40+,41-,42-,43-,44-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
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n/an/an/an/a 42n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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n/an/an/an/a 73n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
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n/an/an/an/a 3.30n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50027084
PNG
(Melatonan)
Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |r|
PDB

KEGG

UniProtKB/SwissProt

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n/an/an/an/a 2.90n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

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n/an/an/an/a 220n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

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n/an/an/an/a>1.00E+3n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 4 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500593
PNG
(CHEMBL4299454)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC2=O)C(N)=O)NC(=O)[C@@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C60H79N15O10/c1-3-4-20-44(68-35(2)76)53(79)72-48-32-51(77)64-26-13-12-23-43(52(61)78)69-56(82)47(30-37-33-66-41-21-10-8-18-39(37)41)71-54(80)45(24-14-27-65-60(62)63)70-55(81)46(29-36-16-6-5-7-17-36)73-58(84)50-25-15-28-75(50)59(85)49(74-57(48)83)31-38-34-67-42-22-11-9-19-40(38)42/h5-11,16-19,21-22,33-34,43-50,66-67H,3-4,12-15,20,23-32H2,1-2H3,(H2,61,78)(H,64,77)(H,68,76)(H,69,82)(H,70,81)(H,71,80)(H,72,79)(H,73,84)(H,74,83)(H4,62,63,65)/t43-,44+,45+,46+,47+,48-,49-,50-/m0/s1
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n/an/an/an/a>1.00E+3n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50500591
PNG
(CHEMBL4299441)
Show SMILES [H][C@]12CCCN1C(=O)[C@@H](Cc1c[nH]c3ccccc13)NC(=O)[C@@H](CC(=O)NCCCC[C@@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C64H81N15O10/c1-3-4-19-48(72-37(2)80)57(83)76-52-34-55(81)68-27-12-11-22-47(56(65)82)73-60(86)51(32-41-35-70-45-20-9-7-17-43(41)45)75-58(84)49(23-13-28-69-64(66)67)74-59(85)50(31-38-25-26-39-15-5-6-16-40(39)30-38)77-62(88)54-24-14-29-79(54)63(89)53(78-61(52)87)33-42-36-71-46-21-10-8-18-44(42)46/h5-10,15-18,20-21,25-26,30,35-36,47-54,70-71H,3-4,11-14,19,22-24,27-29,31-34H2,1-2H3,(H2,65,82)(H,68,81)(H,72,80)(H,73,86)(H,74,85)(H,75,84)(H,76,83)(H,77,88)(H,78,87)(H4,66,67,69)/t47-,48+,49+,50+,51+,52-,53-,54-/m1/s1
PDB

UniProtKB/SwissProt

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n/an/an/an/a 20n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
PDB

KEGG

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n/an/an/an/a 940n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 1 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
PDB

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n/an/an/an/a 1.90n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50500592
PNG
(CHEMBL3752534)
Show SMILES [H][C@@]12CCCN1C(=O)[C@]1([H])CCCN1C(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccc3ccccc3c1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O |r|
Show InChI InChI=1S/C58H78N14O10/c1-3-4-17-42(65-34(2)73)51(76)70-46-32-49(74)62-25-10-9-19-41(50(59)75)66-54(79)45(31-38-33-64-40-18-8-7-16-39(38)40)68-52(77)43(20-11-26-63-58(60)61)67-53(78)44(30-35-23-24-36-14-5-6-15-37(36)29-35)69-55(80)47-21-12-27-71(47)57(82)48-22-13-28-72(48)56(46)81/h5-8,14-16,18,23-24,29,33,41-48,64H,3-4,9-13,17,19-22,25-28,30-32H2,1-2H3,(H2,59,75)(H,62,74)(H,65,73)(H,66,79)(H,67,78)(H,68,77)(H,69,80)(H,70,76)(H4,60,61,63)/t41-,42-,43-,44+,45-,46-,47-,48-/m0/s1
PDB

UniProtKB/SwissProt

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n/an/an/an/a 10n/an/an/an/a



Universit£ di Napoli Federico II

Curated by ChEMBL


Assay Description
Agonist activity at human melanocortin 5 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in prese...

J Med Chem 58: 9773-8 (2015)


Article DOI: 10.1021/acs.jmedchem.5b01285
BindingDB Entry DOI: 10.7270/Q24Q7Z0B
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%