Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NAD-dependent protein deacetylase sirtuin-1 (Homo sapiens (Human)) | BDBM50135227 (CHEMBL3747698) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gause Institute of New Antibiotics Curated by ChEMBL | Assay Description Inhibition of human recombinant SIRT1 deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC as substrate incubated for 45 mins by fluorescen... | J Med Chem 58: 9522-34 (2015) Article DOI: 10.1021/acs.jmedchem.5b00859 BindingDB Entry DOI: 10.7270/Q21Z467Q | |||||||||||
More data for this Ligand-Target Pair |