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PubMed code 26633734

Compile data set for download or QSAR
Found 1 hit of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))
BDBM50135227
PNG
(CHEMBL3747698)
Show SMILES CNCCNc1c2C(=O)c3ccccc3C(=O)c2c(NCCNC)c2occc12
Show InChI InChI=1S/C22H24N4O3/c1-23-8-10-25-18-15-7-12-29-22(15)19(26-11-9-24-2)17-16(18)20(27)13-5-3-4-6-14(13)21(17)28/h3-7,12,23-26H,8-11H2,1-2H3
PDB

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KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.93E+3n/an/an/an/an/an/a



Gause Institute of New Antibiotics

Curated by ChEMBL


Assay Description
Inhibition of human recombinant SIRT1 deacetylase activity using Arg-His-Lys-Lys(epsilon-acetyl)-AMC as substrate incubated for 45 mins by fluorescen...


J Med Chem 58: 9522-34 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00859
BindingDB Entry DOI: 10.7270/Q21Z467Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%