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PubMed code 26649766

Compile data set for download or QSAR
Found 2 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50139117
PNG
(CHEMBL3759668)
Show SMILES CN(C)CCCCn1c(N)c(-c2nc3ccccc3[nH]2)c2nc(C#N)c(nc12)C#N
Show InChI InChI=1S/C21H21N9/c1-29(2)9-5-6-10-30-19(24)17(20-26-13-7-3-4-8-14(13)27-20)18-21(30)28-16(12-23)15(11-22)25-18/h3-4,7-8H,5-6,9-10,24H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 900n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of purified human topoisomerase 2-mediated relaxation of supercoiled pBR322 DNA at 50 uM incubated for 30 mins in presence of 1 mM ATP by ...

J Med Chem 59: 238-52 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01284
BindingDB Entry DOI: 10.7270/Q27946HM
More data for this
Ligand-Target Pair
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50139117
PNG
(CHEMBL3759668)
Show SMILES CN(C)CCCCn1c(N)c(-c2nc3ccccc3[nH]2)c2nc(C#N)c(nc12)C#N
Show InChI InChI=1S/C21H21N9/c1-29(2)9-5-6-10-30-19(24)17(20-26-13-7-3-4-8-14(13)27-20)18-21(30)28-16(12-23)15(11-22)25-18/h3-4,7-8H,5-6,9-10,24H2,1-2H3,(H,26,27)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.65E+4n/an/an/an/an/an/a



Sun Yat-sen University

Curated by ChEMBL


Assay Description
Inhibition of purified human topoisomerase 2-mediated relaxation of supercoiled pBR322 DNA at 50 uM incubated for 30 mins in presence of 4 mM ATP by ...

J Med Chem 59: 238-52 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01284
BindingDB Entry DOI: 10.7270/Q27946HM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%