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PubMed code 26653877

Compile data set for download or QSAR
Found 47 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutamate receptor 2


(Rattus norvegicus)		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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PubMed
 1.74E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 2


(Homo sapiens (Human))		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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 2.26E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from GluA2 LBD (unknown origin) incubated for 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 2


(Rattus norvegicus)		BDBM50304101
PNG
((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO3/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(19)7-9/h1-5,7,13,19H,6,18H2,(H,20,21)
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 5.03E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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 6.65E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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 6.88E+3n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA3o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50304101
PNG
((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO3/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(19)7-9/h1-5,7,13,19H,6,18H2,(H,20,21)
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 1.71E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 2.40E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 3.96E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK3A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142607
PNG
(CHEMBL3759390)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(CO)c1)C(O)=O
Show InChI InChI=1S/C16H15Cl2NO3/c17-13-6-10(7-14(19)16(21)22)5-12(15(13)18)11-3-1-2-9(4-11)8-20/h1-6,14,20H,7-8,19H2,(H,21,22)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142603
PNG
(CHEMBL3759469)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1ccc(O)c(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO4/c16-10-4-7(5-11(18)15(21)22)3-9(14(10)17)8-1-2-12(19)13(20)6-8/h1-4,6,11,19-20H,5,18H2,(H,21,22)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142605
PNG
(CHEMBL3759527)
Show SMILES COc1cccc(c1)-c1cc(CC(N)C(O)=O)cc(Cl)c1Cl
Show InChI InChI=1S/C16H15Cl2NO3/c1-22-11-4-2-3-10(8-11)12-5-9(6-13(17)15(12)18)7-14(19)16(20)21/h2-6,8,14H,7,19H2,1H3,(H,20,21)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142612
PNG
(CHEMBL3758318)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1ccc(O)nc1)C(O)=O
Show InChI InChI=1S/C14H12Cl2N2O3/c15-10-4-7(5-11(17)14(20)21)3-9(13(10)16)8-1-2-12(19)18-6-8/h1-4,6,11H,5,17H2,(H,18,19)(H,20,21)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142606
PNG
(CHEMBL3758252)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1ccc2OCCOc2c1)C(O)=O
Show InChI InChI=1S/C17H15Cl2NO4/c18-12-6-9(7-13(20)17(21)22)5-11(16(12)19)10-1-2-14-15(8-10)24-4-3-23-14/h1-2,5-6,8,13H,3-4,7,20H2,(H,21,22)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142609
PNG
(CHEMBL3759138)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(N)c1)C(O)=O
Show InChI InChI=1S/C15H14Cl2N2O2/c16-12-5-8(6-13(19)15(20)21)4-11(14(12)17)9-2-1-3-10(18)7-9/h1-5,7,13H,6,18-19H2,(H,20,21)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142610
PNG
(CHEMBL3759124)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(c1)S(N)(=O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2N2O4S/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(7-9)24(19,22)23/h1-5,7,13H,6,18H2,(H,20,21)(H2,19,22,23)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142608
PNG
(CHEMBL3759809)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1ccc(CO)cc1)C(O)=O
Show InChI InChI=1S/C16H15Cl2NO3/c17-13-6-10(7-14(19)16(21)22)5-12(15(13)18)11-3-1-9(8-20)2-4-11/h1-6,14,20H,7-8,19H2,(H,21,22)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142604
PNG
(CHEMBL3759334)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cc(O)cc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO4/c16-12-2-7(3-13(18)15(21)22)1-11(14(12)17)8-4-9(19)6-10(20)5-8/h1-2,4-6,13,19-20H,3,18H2,(H,21,22)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142616
PNG
(CHEMBL3759154)
Show SMILES NC(Cc1cccc(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142611
PNG
(CHEMBL3759856)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1ccc(cc1)S(N)(=O)=O)C(O)=O
Show InChI InChI=1S/C15H14Cl2N2O4S/c16-12-6-8(7-13(18)15(20)21)5-11(14(12)17)9-1-3-10(4-2-9)24(19,22)23/h1-6,13H,7,18H2,(H,20,21)(H2,19,22,23)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142613
PNG
(CHEMBL3758779)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)
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>5.00E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50304101
PNG
((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO3/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(19)7-9/h1-5,7,13,19H,6,18H2,(H,20,21)
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 5.23E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK3A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 5.41E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 5.47E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA3o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 3


(RAT)		BDBM50304101
PNG
((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO3/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(19)7-9/h1-5,7,13,19H,6,18H2,(H,20,21)
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 5.51E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA3o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50304101
PNG
((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO3/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(19)7-9/h1-5,7,13,19H,6,18H2,(H,20,21)
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 7.81E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK2(V,C,R)A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting m...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Homo sapiens (Human))		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 8.40E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from GluA2 LBD (unknown origin) incubated for 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50304101
PNG
((RS)-2-Amino-3-(5,6-dichloro-3'-hydroxybiphenyl-3-...)
Show SMILES NC(Cc1cc(Cl)c(Cl)c(c1)-c1cccc(O)c1)C(O)=O
Show InChI InChI=1S/C15H13Cl2NO3/c16-12-5-8(6-13(18)15(20)21)4-11(14(12)17)9-2-1-3-10(19)7-9/h1-5,7,13,19H,6,18H2,(H,20,21)
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 9.23E+4n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50142617
PNG
(CHEMBL3758644)
Show SMILES N[C@@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK3A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50142615
PNG
(CHEMBL3759684)
Show SMILES N[C@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK2(V,C,R)A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting m...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50142617
PNG
(CHEMBL3758644)
Show SMILES N[C@@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA3o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50142615
PNG
(CHEMBL3759684)
Show SMILES N[C@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142615
PNG
(CHEMBL3759684)
Show SMILES N[C@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 3


(RAT)		BDBM50142615
PNG
(CHEMBL3759684)
Show SMILES N[C@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA3o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50142617
PNG
(CHEMBL3758644)
Show SMILES N[C@@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from full length rat cloned GluA2(R)o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation count...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50142617
PNG
(CHEMBL3758644)
Show SMILES N[C@@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK3A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 3


(Rattus norvegicus)		BDBM50142615
PNG
(CHEMBL3759684)
Show SMILES N[C@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK3A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 1


(Rattus norvegicus (Rat))		BDBM50142615
PNG
(CHEMBL3759684)
Show SMILES N[C@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]AMPA from rat cloned GluA1o receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting method

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142617
PNG
(CHEMBL3758644)
Show SMILES N[C@@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50142617
PNG
(CHEMBL3758644)
Show SMILES N[C@@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m0/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK2(V,C,R)A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting m...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK2(V,C,R)A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting m...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1


(RAT)		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 1.05E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from recombinant rat GluK1(Q)1b receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2


(Rattus norvegicus)		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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 1.36E+5n/an/an/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Displacement of [3H]SYM2081 from cloned rat GluK2(V,C,R)A receptor expressed in sf9 cells incubated for 1 to 2 hrs by liquid scintillation counting m...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair
Glutamate receptor 2


(Rattus norvegicus)		BDBM50142614
PNG
(CHEMBL3758336)
Show SMILES N[C@@H](Cc1cc(Cl)c(Cl)c(c1)-c1cncc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C14H12Cl2N2O3/c15-11-2-7(3-12(17)14(20)21)1-10(13(11)16)8-4-9(19)6-18-5-8/h1-2,4-6,12,19H,3,17H2,(H,20,21)/t12-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant rat GluA2(Q)i expressed in xenopus oocytes assessed as inhibition of L-glutamate-induced intracellular calciu...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 2


(Rattus norvegicus)		BDBM50142618
PNG
(CHEMBL3759959)
Show SMILES N[C@H](Cc1cccc(c1)-c1cccc(O)c1)C(O)=O |r|
Show InChI InChI=1S/C15H15NO3/c16-14(15(18)19)8-10-3-1-4-11(7-10)12-5-2-6-13(17)9-12/h1-7,9,14,17H,8,16H2,(H,18,19)/t14-/m1/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Antagonist activity against recombinant rat GluA2(Q)i expressed in xenopus oocytes assessed as inhibition of L-glutamate-induced intracellular calciu...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 2


(Homo sapiens (Human))		BDBM50192229
PNG
(3-Bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-1,1-dioxo-...)
Show SMILES NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C2CC3CC2C=C3)cc1Cl |c:21,TLB:9:14:17:19.20|
Show InChI InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
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PubMed
n/an/an/an/a 7.60E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GluA2(Q)i expressed in HEK293 cells assessed as enhancement of glutamate-evoked desensitized current by whole cell patch cl...

J Med Chem 59: 448-61 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01666
BindingDB Entry DOI: 10.7270/Q2VQ34JK
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
* indicates data uncertainty>20%