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PubMed code 26684851

Compile data set for download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human ERG

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134444
PNG
(CHEMBL3747085)
Show SMILES Cc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H18N4O2/c1-14-7-8-18(20-12-14)22-9-10-23-17(19(22)24)11-15(21-23)13-25-16-5-3-2-4-6-16/h2-8,11-12H,9-10,13H2,1H3
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n/an/an/an/a 186n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134446
PNG
(CHEMBL3747597)
Show SMILES Fc1cnc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C17H14FN5O2/c18-12-9-19-17(20-10-12)22-6-7-23-15(16(22)24)8-13(21-23)11-25-14-4-2-1-3-5-14/h1-5,8-10H,6-7,11H2
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n/an/an/an/a 759n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134455
PNG
(CHEMBL3747522)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccn3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-4-6-15(7-5-13)22-9-10-23-16(18(22)24)11-14(21-23)12-25-17-3-1-2-8-20-17/h1-8,11H,9-10,12H2
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n/an/an/an/a 490n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134440
PNG
(CHEMBL3745940)
Show SMILES O=C1N(CCn2nc(COc3ccccc3)cc12)c1ccccn1
Show InChI InChI=1S/C18H16N4O2/c23-18-16-12-14(13-24-15-6-2-1-3-7-15)20-22(16)11-10-21(18)17-8-4-5-9-19-17/h1-9,12H,10-11,13H2
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n/an/an/an/a 760n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134463
PNG
(CHEMBL3747012)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccncc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-1-3-15(4-2-13)22-9-10-23-17(18(22)24)11-14(21-23)12-25-16-5-7-20-8-6-16/h1-8,11H,9-10,12H2
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n/an/an/an/a 690n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134465
PNG
(CHEMBL3746325)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3cccc(F)c3)cc2C1=O
Show InChI InChI=1S/C18H14F2N4O2/c19-12-2-1-3-15(8-12)26-11-14-9-16-18(25)23(6-7-24(16)22-14)17-5-4-13(20)10-21-17/h1-5,8-10H,6-7,11H2
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n/an/an/an/a 91n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by [35S]-GTPgammaS binding assay

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134479
PNG
(CHEMBL3745901)
Show SMILES Fc1ccccc1N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-16-8-4-5-9-17(16)22-10-11-23-18(19(22)24)12-14(21-23)13-25-15-6-2-1-3-7-15/h1-9,12H,10-11,13H2
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n/an/an/an/a 158n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134480
PNG
(CHEMBL3746731)
Show SMILES Fc1cccc(c1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-5-4-6-16(11-14)22-9-10-23-18(19(22)24)12-15(21-23)13-25-17-7-2-1-3-8-17/h1-8,11-12H,9-10,13H2
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n/an/an/an/a 126n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134438
PNG
(CHEMBL3747073)
Show SMILES Cc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H19N3O2/c1-15-7-9-17(10-8-15)22-11-12-23-19(20(22)24)13-16(21-23)14-25-18-5-3-2-4-6-18/h2-10,13H,11-12,14H2,1H3
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n/an/an/an/a 71n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134440
PNG
(CHEMBL3745940)
Show SMILES O=C1N(CCn2nc(COc3ccccc3)cc12)c1ccccn1
Show InChI InChI=1S/C18H16N4O2/c23-18-16-12-14(13-24-15-6-2-1-3-7-15)20-22(16)11-10-21(18)17-8-4-5-9-19-17/h1-9,12H,10-11,13H2
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n/an/an/an/a 759n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 126n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134445
PNG
(CHEMBL3746298)
Show SMILES COc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H18N4O3/c1-25-16-7-8-18(20-12-16)22-9-10-23-17(19(22)24)11-14(21-23)13-26-15-5-3-2-4-6-15/h2-8,11-12H,9-10,13H2,1H3
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n/an/an/an/a 617n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134474
PNG
(CHEMBL3746294)
Show SMILES Cc1c(COc2ccccc2)nn2CCN(C(=O)c12)c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-14-18(13-26-17-5-3-2-4-6-17)22-24-12-11-23(20(25)19(14)24)16-9-7-15(21)8-10-16/h2-10H,11-13H2,1H3
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n/an/an/an/a 1.23E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134476
PNG
(CHEMBL3746299)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)c(Cl)c2C1=O
Show InChI InChI=1S/C19H15ClFN3O2/c20-17-16(12-26-15-4-2-1-3-5-15)22-24-11-10-23(19(25)18(17)24)14-8-6-13(21)7-9-14/h1-9H,10-12H2
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n/an/an/an/a<3.02E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134480
PNG
(CHEMBL3746731)
Show SMILES Fc1cccc(c1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-5-4-6-16(11-14)22-9-10-23-18(19(22)24)12-15(21-23)13-25-17-7-2-1-3-8-17/h1-8,11-12H,9-10,13H2
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n/an/an/an/a 130n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134437
PNG
(CHEMBL3746591)
Show SMILES Fc1ccc(cc1F)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H15F2N3O2/c20-16-7-6-14(11-17(16)21)23-8-9-24-18(19(23)25)10-13(22-24)12-26-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 87n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134438
PNG
(CHEMBL3747073)
Show SMILES Cc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H19N3O2/c1-15-7-9-17(10-8-15)22-11-12-23-19(20(22)24)13-16(21-23)14-25-18-5-3-2-4-6-18/h2-10,13H,11-12,14H2,1H3
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n/an/an/an/a 71n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134449
PNG
(CHEMBL3745812)
Show SMILES Fc1ccc(OCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H15F2N3O2/c20-13-1-5-16(6-2-13)23-9-10-24-18(19(23)25)11-15(22-24)12-26-17-7-3-14(21)4-8-17/h1-8,11H,9-10,12H2
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n/an/an/an/a 100n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134457
PNG
(CHEMBL3746779)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3cccnc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-3-5-15(6-4-13)22-8-9-23-17(18(22)24)10-14(21-23)12-25-16-2-1-7-20-11-16/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 3.98E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Rattus norvegicus (Rat))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assay

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134441
PNG
(CHEMBL3746240)
Show SMILES O=C1N(CCn2nc(COc3ccccc3)cc12)c1cccnc1
Show InChI InChI=1S/C18H16N4O2/c23-18-17-11-14(13-24-16-6-2-1-3-7-16)20-22(17)10-9-21(18)15-5-4-8-19-12-15/h1-8,11-12H,9-10,13H2
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n/an/an/an/a 2.09E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134442
PNG
(CHEMBL3747717)
Show SMILES O=C1N(CCn2nc(COc3ccccc3)cc12)c1ccncc1
Show InChI InChI=1S/C18H16N4O2/c23-18-17-12-14(13-24-16-4-2-1-3-5-16)20-22(17)11-10-21(18)15-6-8-19-9-7-15/h1-9,12H,10-11,13H2
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n/an/an/an/a 2.09E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134457
PNG
(CHEMBL3746779)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3cccnc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-3-5-15(6-4-13)22-8-9-23-17(18(22)24)10-14(21-23)12-25-16-2-1-7-20-11-16/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 3.98E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134453
PNG
(CHEMBL3746604)
Show SMILES Cc1ccc(OCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-14-2-8-18(9-3-14)26-13-16-12-19-20(25)23(10-11-24(19)22-16)17-6-4-15(21)5-7-17/h2-9,12H,10-11,13H2,1H3
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n/an/an/an/a 300n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134468
PNG
(CHEMBL3747072)
Show SMILES CC(Oc1ccccc1)c1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-14(26-17-5-3-2-4-6-17)18-13-19-20(25)23(11-12-24(19)22-18)16-9-7-15(21)8-10-16/h2-10,13-14H,11-12H2,1H3
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n/an/an/an/a 7.76E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134476
PNG
(CHEMBL3746299)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)c(Cl)c2C1=O
Show InChI InChI=1S/C19H15ClFN3O2/c20-17-16(12-26-15-4-2-1-3-5-15)22-24-11-10-23(19(25)18(17)24)14-8-6-13(21)7-9-14/h1-9H,10-12H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 6.76E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells by [35S]-GTPgammaS binding assay

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134463
PNG
(CHEMBL3747012)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccncc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-1-3-15(4-2-13)22-9-10-23-17(18(22)24)11-14(21-23)12-25-16-5-7-20-8-6-16/h1-8,11H,9-10,12H2
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n/an/an/an/a 692n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a 158n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134468
PNG
(CHEMBL3747072)
Show SMILES CC(Oc1ccccc1)c1cc2C(=O)N(CCn2n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-14(26-17-5-3-2-4-6-17)18-13-19-20(25)23(11-12-24(19)22-18)16-9-7-15(21)8-10-16/h2-10,13-14H,11-12H2,1H3
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n/an/an/an/a 7.76E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134473
PNG
(CHEMBL3747078)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)nc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-8-14(9-7-13)22-10-11-23-17(18(22)24)20-16(21-23)12-25-15-4-2-1-3-5-15/h1-9H,10-12H2
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n/an/an/an/a 2.82E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134439
PNG
(CHEMBL3747662)
Show SMILES COc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-7-16(8-10-17)22-11-12-23-19(20(22)24)13-15(21-23)14-26-18-5-3-2-4-6-18/h2-10,13H,11-12,14H2,1H3
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n/an/an/an/a 110n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134441
PNG
(CHEMBL3746240)
Show SMILES O=C1N(CCn2nc(COc3ccccc3)cc12)c1cccnc1
Show InChI InChI=1S/C18H16N4O2/c23-18-17-11-14(13-24-16-6-2-1-3-7-16)20-22(17)10-9-21(18)15-5-4-8-19-12-15/h1-8,11-12H,9-10,13H2
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n/an/an/an/a 2.09E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134442
PNG
(CHEMBL3747717)
Show SMILES O=C1N(CCn2nc(COc3ccccc3)cc12)c1ccncc1
Show InChI InChI=1S/C18H16N4O2/c23-18-17-12-14(13-24-16-4-2-1-3-5-16)20-22(17)11-10-21(18)15-6-8-19-9-7-15/h1-9,12H,10-11,13H2
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n/an/an/an/a 2.09E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134444
PNG
(CHEMBL3747085)
Show SMILES Cc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H18N4O2/c1-14-7-8-18(20-12-14)22-9-10-23-17(19(22)24)11-15(21-23)13-25-16-5-3-2-4-6-16/h2-8,11-12H,9-10,13H2,1H3
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n/an/an/an/a 190n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134455
PNG
(CHEMBL3747522)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccn3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-4-6-15(7-5-13)22-9-10-23-16(18(22)24)11-14(21-23)12-25-17-3-1-2-8-20-17/h1-8,11H,9-10,12H2
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n/an/an/an/a 490n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a 160n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134467
PNG
(CHEMBL3747260)
Show SMILES Fc1ccnc(c1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-14-6-7-20-16(10-14)22-8-9-23-15(18(22)24)11-17(21-23)25-12-13-4-2-1-3-5-13/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a 3.39E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134448
PNG
(CHEMBL3747118)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3cccc(F)c3)cc2C1=O
Show InChI InChI=1S/C19H15F2N3O2/c20-13-4-6-16(7-5-13)23-8-9-24-18(19(23)25)11-15(22-24)12-26-17-3-1-2-14(21)10-17/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 100n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134467
PNG
(CHEMBL3747260)
Show SMILES Fc1ccnc(c1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-14-6-7-20-16(10-14)22-8-9-23-15(18(22)24)11-17(21-23)25-12-13-4-2-1-3-5-13/h1-7,10-11H,8-9,12H2
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n/an/an/an/a<3.02E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134469
PNG
(CHEMBL3746344)
Show SMILES Fc1ccc(cc1)N1CCCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H18FN3O2/c21-15-7-9-17(10-8-15)23-11-4-12-24-19(20(23)25)13-16(22-24)14-26-18-5-2-1-3-6-18/h1-3,5-10,13H,4,11-12,14H2
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n/an/an/an/a 540n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 8


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu8 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 6


(Rattus norvegicus (Rat))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGlu6 receptor expressed in CHO cells by [35S]-GTPgammaS binding assay

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134447
PNG
(CHEMBL3747433)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3F)cc2C1=O
Show InChI InChI=1S/C19H15F2N3O2/c20-13-5-7-15(8-6-13)23-9-10-24-17(19(23)25)11-14(22-24)12-26-18-4-2-1-3-16(18)21/h1-8,11H,9-10,12H2
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n/an/an/an/a 148n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134465
PNG
(CHEMBL3746325)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3cccc(F)c3)cc2C1=O
Show InChI InChI=1S/C18H14F2N4O2/c19-12-2-1-3-15(8-12)26-11-14-9-16-18(25)23(6-7-24(16)22-14)17-5-4-13(20)10-21-17/h1-5,8-10H,6-7,11H2
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n/an/an/an/a 91n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134469
PNG
(CHEMBL3746344)
Show SMILES Fc1ccc(cc1)N1CCCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H18FN3O2/c21-15-7-9-17(10-8-15)23-11-4-12-24-19(20(23)25)13-16(22-24)14-26-18-5-2-1-3-6-18/h1-3,5-10,13H,4,11-12,14H2
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n/an/an/an/a 87n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 130n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134446
PNG
(CHEMBL3747597)
Show SMILES Fc1cnc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C17H14FN5O2/c18-12-9-19-17(20-10-12)22-6-7-23-15(16(22)24)8-13(21-23)11-25-14-4-2-1-3-5-14/h1-5,8-10H,6-7,11H2
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n/an/an/an/a 760n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134447
PNG
(CHEMBL3747433)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3F)cc2C1=O
Show InChI InChI=1S/C19H15F2N3O2/c20-13-5-7-15(8-6-13)23-9-10-24-17(19(23)25)11-14(22-24)12-26-18-4-2-1-3-16(18)21/h1-8,11H,9-10,12H2
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n/an/an/an/a 150n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134469
PNG
(CHEMBL3746344)
Show SMILES Fc1ccc(cc1)N1CCCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H18FN3O2/c21-15-7-9-17(10-8-15)23-11-4-12-24-19(20(23)25)13-16(22-24)14-26-18-5-2-1-3-6-18/h1-3,5-10,13H,4,11-12,14H2
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n/an/an/an/a 87.1n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134437
PNG
(CHEMBL3746591)
Show SMILES Fc1ccc(cc1F)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H15F2N3O2/c20-16-7-6-14(11-17(16)21)23-8-9-24-18(19(23)25)10-13(22-24)12-26-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 87n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134449
PNG
(CHEMBL3745812)
Show SMILES Fc1ccc(OCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H15F2N3O2/c20-13-1-5-16(6-2-13)23-9-10-24-18(19(23)25)11-15(22-24)12-26-17-7-3-14(21)4-8-17/h1-8,11H,9-10,12H2
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n/an/an/an/a 105n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134464
PNG
(CHEMBL3747732)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccc(F)cn3)cc2C1=O
Show InChI InChI=1S/C18H14F2N4O2/c19-12-1-4-15(5-2-12)23-7-8-24-16(18(23)25)9-14(22-24)11-26-17-6-3-13(20)10-21-17/h1-6,9-10H,7-8,11H2
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n/an/an/an/a 7.94E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134479
PNG
(CHEMBL3745901)
Show SMILES Fc1ccccc1N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-16-8-4-5-9-17(16)22-10-11-23-18(19(22)24)12-14(21-23)13-25-15-6-2-1-3-7-15/h1-9,12H,10-11,13H2
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n/an/an/an/a 160n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134435
PNG
(CHEMBL3747735)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-6-8-16(9-7-14)22-10-11-23-18(19(22)24)12-15(21-23)13-25-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2
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n/an/an/an/a 65n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134445
PNG
(CHEMBL3746298)
Show SMILES COc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H18N4O3/c1-25-16-7-8-18(20-12-16)22-9-10-23-17(19(22)24)11-14(21-23)13-26-15-5-3-2-4-6-15/h2-8,11-12H,9-10,13H2,1H3
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n/an/an/an/a 620n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134448
PNG
(CHEMBL3747118)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3cccc(F)c3)cc2C1=O
Show InChI InChI=1S/C19H15F2N3O2/c20-13-4-6-16(7-5-13)23-8-9-24-18(19(23)25)11-15(22-24)12-26-17-3-1-2-14(21)10-17/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 100n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134438
PNG
(CHEMBL3747073)
Show SMILES Cc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H19N3O2/c1-15-7-9-17(10-8-15)22-11-12-23-19(20(22)24)13-16(21-23)14-25-18-5-3-2-4-6-18/h2-10,13H,11-12,14H2,1H3
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n/an/an/an/a 150n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134435
PNG
(CHEMBL3747735)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-6-8-16(9-7-14)22-10-11-23-18(19(22)24)12-15(21-23)13-25-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2
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n/an/an/an/a 65n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134436
PNG
(CHEMBL3746540)
Show SMILES Fc1ccc(N2CCn3nc(COc4ccccc4)cc3C2=O)c(F)c1
Show InChI InChI=1S/C19H15F2N3O2/c20-13-6-7-17(16(21)10-13)23-8-9-24-18(19(23)25)11-14(22-24)12-26-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 100n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134439
PNG
(CHEMBL3747662)
Show SMILES COc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C20H19N3O3/c1-25-17-9-7-16(8-10-17)22-11-12-23-19(20(22)24)13-15(21-23)14-26-18-5-3-2-4-6-18/h2-10,13H,11-12,14H2,1H3
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n/an/an/an/a 115n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134453
PNG
(CHEMBL3746604)
Show SMILES Cc1ccc(OCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-14-2-8-18(9-3-14)26-13-16-12-19-20(25)23(10-11-24(19)22-16)17-6-4-15(21)5-7-17/h2-9,12H,10-11,13H2,1H3
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n/an/an/an/a 302n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134436
PNG
(CHEMBL3746540)
Show SMILES Fc1ccc(N2CCn3nc(COc4ccccc4)cc3C2=O)c(F)c1
Show InChI InChI=1S/C19H15F2N3O2/c20-13-6-7-17(16(21)10-13)23-8-9-24-18(19(23)25)11-14(22-24)12-26-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a 100n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134464
PNG
(CHEMBL3747732)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccc(F)cn3)cc2C1=O
Show InChI InChI=1S/C18H14F2N4O2/c19-12-1-4-15(5-2-12)23-7-8-24-16(18(23)25)9-14(22-24)11-26-17-6-3-13(20)10-21-17/h1-6,9-10H,7-8,11H2
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n/an/an/an/a 7.94E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134473
PNG
(CHEMBL3747078)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)nc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-8-14(9-7-13)22-10-11-23-17(18(22)24)20-16(21-23)12-25-15-4-2-1-3-5-15/h1-9H,10-12H2
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n/an/an/an/a 2.81E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50134474
PNG
(CHEMBL3746294)
Show SMILES Cc1c(COc2ccccc2)nn2CCN(C(=O)c12)c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-14-18(13-26-17-5-3-2-4-6-17)22-24-12-11-23(20(25)19(14)24)16-9-7-15(21)8-10-16/h2-10H,11-13H2,1H3
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n/an/an/an/a 1.23E+3n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134435
PNG
(CHEMBL3747735)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-14-6-8-16(9-7-14)22-10-11-23-18(19(22)24)12-15(21-23)13-25-17-4-2-1-3-5-17/h1-9,12H,10-11,13H2
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n/an/an/an/a 74n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134449
PNG
(CHEMBL3745812)
Show SMILES Fc1ccc(OCc2cc3C(=O)N(CCn3n2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H15F2N3O2/c20-13-1-5-16(6-2-13)23-9-10-24-18(19(23)25)11-15(22-24)12-26-17-7-3-14(21)4-8-17/h1-8,11H,9-10,12H2
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n/an/an/an/a 34n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 3


(Homo sapiens (Human))		BDBM50134455
PNG
(CHEMBL3747522)
Show SMILES Fc1ccc(cc1)N1CCn2nc(COc3ccccn3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-4-6-15(7-5-13)22-9-10-23-16(18(22)24)11-14(21-23)12-25-17-3-1-2-8-20-17/h1-8,11H,9-10,12H2
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n/an/an/an/a 290n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilization

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu1 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 7


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu7 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134443
PNG
(CHEMBL3746457)
Show SMILES Fc1ccc(nc1)N1CCn2nc(COc3ccccc3)cc2C1=O
Show InChI InChI=1S/C18H15FN4O2/c19-13-6-7-17(20-11-13)22-8-9-23-16(18(22)24)10-14(21-23)12-25-15-4-2-1-3-5-15/h1-7,10-11H,8-9,12H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells assessed as calcium mobilization by fluorescence analysis

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
PDB

UniProtKB/SwissProt

antibodypedia
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CHEMBL
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UniChem

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Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in HEK293 cells by [35S]-GTPgammaS binding assay

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50134466
PNG
(CHEMBL3747116)
Show SMILES Fc1ccc(cc1)N1CCn2nc(OCc3ccccc3)cc2C1=O
Show InChI InChI=1S/C19H16FN3O2/c20-15-6-8-16(9-7-15)22-10-11-23-17(19(22)24)12-18(21-23)25-13-14-4-2-1-3-5-14/h1-9,12H,10-11,13H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Janssen Research and Development

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGlu4 receptor expressed in L929sA cells by [35S]-GTPgammaS binding assay

Bioorg Med Chem Lett 26: 429-34 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.098
BindingDB Entry DOI: 10.7270/Q2SJ1NGS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%