Found 10 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50030474
(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)Show InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid PDB UniChem
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137109
(CHEMBL3754507)Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2ccc(-[#8]-[#6]-c3ccccc3)cc2)-[#6](=O)-[#7]-1 Show InChI InChI=1S/C18H14N2O4/c21-16-15(17(22)20-18(23)19-16)10-12-6-8-14(9-7-12)24-11-13-4-2-1-3-5-13/h1-10H,11H2,(H2,19,20,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137108
(CHEMBL3753473)Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2ccc(cc2)-[#7](-[#6]-[#6]-[#8]-c2ccc(cc2)C#N)-[#6]-[#6]-[#8]-c2ccc(cc2)C#N)-[#6](=O)-[#7]-1 Show InChI InChI=1S/C29H23N5O5/c30-18-21-3-9-24(10-4-21)38-15-13-34(14-16-39-25-11-5-22(19-31)6-12-25)23-7-1-20(2-8-23)17-26-27(35)32-29(37)33-28(26)36/h1-12,17H,13-16H2,(H2,32,33,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137110
(CHEMBL3753490)Show SMILES [#8-]-[#7+](=O)-c1ccc(-[#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]-c2ccc(cc2)-[#7+](-[#8-])=O)-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-3=O)cc2)cc1 Show InChI InChI=1S/C27H23N5O9/c33-25-24(26(34)29-27(35)28-25)17-18-1-3-19(4-2-18)30(13-15-40-22-9-5-20(6-10-22)31(36)37)14-16-41-23-11-7-21(8-12-23)32(38)39/h1-12,17H,13-16H2,(H2,28,29,33,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137111
(CHEMBL3752848)Show SMILES [#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]C(c1ccccc1)(c1ccccc1)c1ccccc1)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C34H31N3O5/c38-22-20-37(29-18-16-25(17-19-29)24-30-31(39)35-33(41)36-32(30)40)21-23-42-34(26-10-4-1-5-11-26,27-12-6-2-7-13-27)28-14-8-3-9-15-28/h1-19,24,38H,20-23H2,(H2,35,36,39,40,41) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137104
(CHEMBL3753560)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]-[#6]-c2ccc(-[#8]-[#6])cc2)-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-3=O)cc2)cc1 Show InChI InChI=1S/C31H33N3O7/c1-38-26-11-5-23(6-12-26)20-40-17-15-34(16-18-41-21-24-7-13-27(39-2)14-8-24)25-9-3-22(4-10-25)19-28-29(35)32-31(37)33-30(28)36/h3-14,19H,15-18,20-21H2,1-2H3,(H2,32,33,35,36,37) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137107
(CHEMBL3754461)Show SMILES O=[#6]-1-[#7]-[#6](=O)\[#6](=[#6]/c2ccc(cc2)-[#7](-[#6]-[#6]-[#8]-[#6]-c2ccccc2)-[#6]-[#6]-[#8]-[#6]-c2ccccc2)-[#6](=O)-[#7]-1 Show InChI InChI=1S/C29H29N3O5/c33-27-26(28(34)31-29(35)30-27)19-22-11-13-25(14-12-22)32(15-17-36-20-23-7-3-1-4-8-23)16-18-37-21-24-9-5-2-6-10-24/h1-14,19H,15-18,20-21H2,(H2,30,31,33,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137105
(CHEMBL3753871)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]-c2ccccn2)-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-3=O)cc2)cc1 Show InChI InChI=1S/C28H28N4O6/c1-36-23-11-7-21(8-12-23)19-37-16-14-32(15-17-38-25-4-2-3-13-29-25)22-9-5-20(6-10-22)18-24-26(33)30-28(35)31-27(24)34/h2-13,18H,14-17,19H2,1H3,(H2,30,31,33,34,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137096
(CHEMBL3753308)Show SMILES [#6]-[#8]-c1ccc(-[#6]-[#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]-[#6]-c2ccccc2)-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-3=O)cc2)cc1 Show InChI InChI=1S/C30H31N3O6/c1-37-26-13-9-24(10-14-26)21-39-18-16-33(15-17-38-20-23-5-3-2-4-6-23)25-11-7-22(8-12-25)19-27-28(34)31-30(36)32-29(27)35/h2-14,19H,15-18,20-21H2,1H3,(H2,31,32,34,35,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.91E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50137106
(CHEMBL3754373)Show SMILES [#6]-[#6](=O)-[#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]-[#6]-c1ccccc1)-c1ccc(\[#6]=[#6]-2/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-2=O)cc1 Show InChI InChI=1S/C24H25N3O6/c1-17(28)33-14-12-27(11-13-32-16-19-5-3-2-4-6-19)20-9-7-18(8-10-20)15-21-22(29)25-24(31)26-23(21)30/h2-10,15H,11-14,16H2,1H3,(H2,25,26,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER)
Curated by ChEMBL
| Assay Description Binding affinity to GST-tagged human PPAR-gamma receptor by FRET assay |
Eur J Med Chem 108: 423-35 (2016)
Article DOI: 10.1016/j.ejmech.2015.11.030 BindingDB Entry DOI: 10.7270/Q2KP841X |
More data for this Ligand-Target Pair | |