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PubMed code 26755394

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50139061
PNG
(CHEMBL3753101)
Show SMILES COc1ccc(CCNC(=O)c2cc3ccccc3s2)cc1OC
Show InChI InChI=1S/C19H19NO3S/c1-22-15-8-7-13(11-16(15)23-2)9-10-20-19(21)18-12-14-5-3-4-6-17(14)24-18/h3-8,11-12H,9-10H2,1-2H3,(H,20,21)
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n/an/a 150n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50024418
PNG
(5-Methyl-thiophene-2-carboxylic acid (3-imidazol-1...)
Show SMILES Cc1ccc(s1)C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C12H15N3OS/c1-10-3-4-11(17-10)12(16)14-5-2-7-15-8-6-13-9-15/h3-4,6,8-9H,2,5,7H2,1H3,(H,14,16)
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n/an/a 170n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140167
PNG
(CHEMBL1417786)
Show SMILES COc1ccc(CCNC(=O)c2ccc(C)s2)cc1OC
Show InChI InChI=1S/C16H19NO3S/c1-11-4-7-15(21-11)16(18)17-9-8-12-5-6-13(19-2)14(10-12)20-3/h4-7,10H,8-9H2,1-3H3,(H,17,18)
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n/an/a 860n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140162
PNG
(CHEMBL3753583)
Show SMILES COc1ccc(CCNC(=O)CNC(=O)c2ccc(C)s2)cc1OC
Show InChI InChI=1S/C18H22N2O4S/c1-12-4-7-16(25-12)18(22)20-11-17(21)19-9-8-13-5-6-14(23-2)15(10-13)24-3/h4-7,10H,8-9,11H2,1-3H3,(H,19,21)(H,20,22)
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n/an/a 950n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50024407
PNG
(Benzofuran-2-carboxylic acid (3-imidazol-1-yl-prop...)
Show SMILES O=C(NCCCn1ccnc1)c1cc2ccccc2o1
Show InChI InChI=1S/C15H15N3O2/c19-15(17-6-3-8-18-9-7-16-11-18)14-10-12-4-1-2-5-13(12)20-14/h1-2,4-5,7,9-11H,3,6,8H2,(H,17,19)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140161
PNG
(CHEMBL3752639)
Show SMILES O=C(NCCCn1ccnc1)c1cc2ccccc2s1
Show InChI InChI=1S/C15H15N3OS/c19-15(17-6-3-8-18-9-7-16-11-18)14-10-12-4-1-2-5-13(12)20-14/h1-2,4-5,7,9-11H,3,6,8H2,(H,17,19)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140160
PNG
(CHEMBL3754708)
Show SMILES COc1ccc(CCNC(=O)c2cc3ccccc3o2)cc1OC
Show InChI InChI=1S/C19H19NO4/c1-22-16-8-7-13(11-17(16)23-2)9-10-20-19(21)18-12-14-5-3-4-6-15(14)24-18/h3-8,11-12H,9-10H2,1-2H3,(H,20,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140164
PNG
(CHEMBL3753289)
Show SMILES COc1ccc(CCNC(=O)c2sccc2C)cc1OC
Show InChI InChI=1S/C16H19NO3S/c1-11-7-9-21-15(11)16(18)17-8-6-12-4-5-13(19-2)14(10-12)20-3/h4-5,7,9-10H,6,8H2,1-3H3,(H,17,18)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50139063
PNG
(CHEMBL3752181)
Show SMILES O=C(NCCCn1ccnc1)\C=C\c1cccnc1
Show InChI InChI=1S/C14H16N4O/c19-14(5-4-13-3-1-6-15-11-13)17-7-2-9-18-10-8-16-12-18/h1,3-6,8,10-12H,2,7,9H2,(H,17,19)/b5-4+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50139065
PNG
(CHEMBL3752007)
Show SMILES Cc1ccsc1C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C12H15N3OS/c1-10-3-8-17-11(10)12(16)14-4-2-6-15-7-5-13-9-15/h3,5,7-9H,2,4,6H2,1H3,(H,14,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140165
PNG
(CHEMBL3752345)
Show SMILES COc1ccc(CCNC(=O)CNC(=O)c2sccc2C)cc1OC
Show InChI InChI=1S/C18H22N2O4S/c1-12-7-9-25-17(12)18(22)20-11-16(21)19-8-6-13-4-5-14(23-2)15(10-13)24-3/h4-5,7,9-10H,6,8,11H2,1-3H3,(H,19,21)(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50139064
PNG
(CHEMBL3752056)
Show SMILES [O-][N+](=O)c1ccc(s1)C(=O)NCCCn1ccnc1
Show InChI InChI=1S/C11H12N4O3S/c16-11(9-2-3-10(19-9)15(17)18)13-4-1-6-14-7-5-12-8-14/h2-3,5,7-8H,1,4,6H2,(H,13,16)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140166
PNG
(CHEMBL3754501)
Show SMILES COc1ccc(CCNC(=O)\C=C\c2ccccn2)cc1OC
Show InChI InChI=1S/C18H20N2O3/c1-22-16-8-6-14(13-17(16)23-2)10-12-20-18(21)9-7-15-5-3-4-11-19-15/h3-9,11,13H,10,12H2,1-2H3,(H,20,21)/b9-7+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50140163
PNG
(CHEMBL3752097)
Show SMILES COc1ccc(CCNC(=O)c2ccc(s2)[N+]([O-])=O)cc1OC
Show InChI InChI=1S/C15H16N2O5S/c1-21-11-4-3-10(9-12(11)22-2)7-8-16-15(18)13-5-6-14(23-13)17(19)20/h3-6,9H,7-8H2,1-2H3,(H,16,18)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of human Nampt using NAM as substrate after 15 mins by fluorometric method

Bioorg Med Chem Lett 26: 765-8 (2016)


Article DOI: 10.1016/j.bmcl.2015.12.101
BindingDB Entry DOI: 10.7270/Q2MK6FRK
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%