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PubMed code 26810711

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Collagenase 3


(Homo sapiens (Human))		BDBM50500717
PNG
(CHEMBL3752564)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)
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n/an/a 2.20n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500712
PNG
(CHEMBL3754243)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C18H23FNO6PS/c1-13(2)18(27(21,22)23)20-28(24,25)17-9-5-15(6-10-17)14-3-7-16(8-4-14)26-12-11-19/h3-10,13,18,20H,11-12H2,1-2H3,(H2,21,22,23)
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n/an/a 2.40n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50500717
PNG
(CHEMBL3752564)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)
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n/an/a 3n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP8 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500718
PNG
(CHEMBL3751997)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500718
PNG
(CHEMBL3751997)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500717
PNG
(CHEMBL3752564)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)
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n/an/a 8.90n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500717
PNG
(CHEMBL3752564)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C17H22NO6PS/c1-12(2)17(25(19,20)21)18-26(22,23)16-10-6-14(7-11-16)13-4-8-15(24-3)9-5-13/h4-12,17-18H,1-3H3,(H2,19,20,21)
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n/an/a 9.30n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500712
PNG
(CHEMBL3754243)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C18H23FNO6PS/c1-13(2)18(27(21,22)23)20-28(24,25)17-9-5-15(6-10-17)14-3-7-16(8-4-14)26-12-11-19/h3-10,13,18,20H,11-12H2,1-2H3,(H2,21,22,23)
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n/an/a 12n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500712
PNG
(CHEMBL3754243)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C18H23FNO6PS/c1-13(2)18(27(21,22)23)20-28(24,25)17-9-5-15(6-10-17)14-3-7-16(8-4-14)26-12-11-19/h3-10,13,18,20H,11-12H2,1-2H3,(H2,21,22,23)
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n/an/a 19n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500718
PNG
(CHEMBL3751997)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50500716
PNG
(CHEMBL3752419)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP8 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500714
PNG
(CHEMBL3754302)
Show SMILES CC(C)C(N(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C25H29FNO6PS/c1-19(2)25(34(28,29)30)27(18-20-6-4-3-5-7-20)35(31,32)24-14-10-22(11-15-24)21-8-12-23(13-9-21)33-17-16-26/h3-15,19,25H,16-18H2,1-2H3,(H2,28,29,30)
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n/an/a 56n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500714
PNG
(CHEMBL3754302)
Show SMILES CC(C)C(N(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C25H29FNO6PS/c1-19(2)25(34(28,29)30)27(18-20-6-4-3-5-7-20)35(31,32)24-14-10-22(11-15-24)21-8-12-23(13-9-21)33-17-16-26/h3-15,19,25H,16-18H2,1-2H3,(H2,28,29,30)
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n/an/a 73n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50500714
PNG
(CHEMBL3754302)
Show SMILES CC(C)C(N(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C25H29FNO6PS/c1-19(2)25(34(28,29)30)27(18-20-6-4-3-5-7-20)35(31,32)24-14-10-22(11-15-24)21-8-12-23(13-9-21)33-17-16-26/h3-15,19,25H,16-18H2,1-2H3,(H2,28,29,30)
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n/an/a 83n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP8 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500716
PNG
(CHEMBL3752419)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m0/s1
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n/an/a 94n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500714
PNG
(CHEMBL3754302)
Show SMILES CC(C)C(N(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)-c1ccc(OCCF)cc1)P(O)(O)=O
Show InChI InChI=1S/C25H29FNO6PS/c1-19(2)25(34(28,29)30)27(18-20-6-4-3-5-7-20)35(31,32)24-14-10-22(11-15-24)21-8-12-23(13-9-21)33-17-16-26/h3-15,19,25H,16-18H2,1-2H3,(H2,28,29,30)
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n/an/a 96n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500713
PNG
(CHEMBL3752747)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1)P(O)(O)=O
Show InChI InChI=1S/C15H18FN2O5PS/c1-10(2)15(24(19,20)21)18-25(22,23)13-6-3-11(4-7-13)12-5-8-14(16)17-9-12/h3-10,15,18H,1-2H3,(H2,19,20,21)
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n/an/a 393n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500713
PNG
(CHEMBL3752747)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1)P(O)(O)=O
Show InChI InChI=1S/C15H18FN2O5PS/c1-10(2)15(24(19,20)21)18-25(22,23)13-6-3-11(4-7-13)12-5-8-14(16)17-9-12/h3-10,15,18H,1-2H3,(H2,19,20,21)
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n/an/a 628n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500716
PNG
(CHEMBL3752419)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m0/s1
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n/an/a 791n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500713
PNG
(CHEMBL3752747)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1)P(O)(O)=O
Show InChI InChI=1S/C15H18FN2O5PS/c1-10(2)15(24(19,20)21)18-25(22,23)13-6-3-11(4-7-13)12-5-8-14(16)17-9-12/h3-10,15,18H,1-2H3,(H2,19,20,21)
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n/an/a 1.03E+3n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50500719
PNG
(CHEMBL3754314)
Show SMILES COCc1ccc(s1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C16H22NO6PS2/c1-11(2)16(24(18,19)20)17-26(21,22)14-7-4-12(5-8-14)15-9-6-13(25-15)10-23-3/h4-9,11,16-17H,10H2,1-3H3,(H2,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP8 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500715
PNG
(CHEMBL3752826)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(C)s1)P(O)(O)=O
Show InChI InChI=1S/C15H20NO5PS2/c1-10(2)15(22(17,18)19)16-24(20,21)13-7-5-12(6-8-13)14-9-4-11(3)23-14/h4-10,15-16H,1-3H3,(H2,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500716
PNG
(CHEMBL3752419)
Show SMILES COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)N[C@H](CCCCCF)P(O)(O)=O |r|
Show InChI InChI=1S/C19H25FNO6PS/c1-27-17-10-6-15(7-11-17)16-8-12-18(13-9-16)29(25,26)21-19(28(22,23)24)5-3-2-4-14-20/h6-13,19,21H,2-5,14H2,1H3,(H2,22,23,24)/t19-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50500715
PNG
(CHEMBL3752826)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(C)s1)P(O)(O)=O
Show InChI InChI=1S/C15H20NO5PS2/c1-10(2)15(22(17,18)19)16-24(20,21)13-7-5-12(6-8-13)14-9-4-11(3)23-14/h4-10,15-16H,1-3H3,(H2,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP8 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500715
PNG
(CHEMBL3752826)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(C)s1)P(O)(O)=O
Show InChI InChI=1S/C15H20NO5PS2/c1-10(2)15(22(17,18)19)16-24(20,21)13-7-5-12(6-8-13)14-9-4-11(3)23-14/h4-10,15-16H,1-3H3,(H2,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
72 kDa type IV collagenase


(Homo sapiens (Human))		BDBM50500719
PNG
(CHEMBL3754314)
Show SMILES COCc1ccc(s1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C16H22NO6PS2/c1-11(2)16(24(18,19)20)17-26(21,22)14-7-4-12(5-8-14)15-9-6-13(25-15)10-23-3/h4-9,11,16-17H,10H2,1-3H3,(H2,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP2 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Matrix metalloproteinase-9


(Homo sapiens (Human))		BDBM50500719
PNG
(CHEMBL3754314)
Show SMILES COCc1ccc(s1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C16H22NO6PS2/c1-11(2)16(24(18,19)20)17-26(21,22)14-7-4-12(5-8-14)15-9-6-13(25-15)10-23-3/h4-9,11,16-17H,10H2,1-3H3,(H2,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of human MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 as substra...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500719
PNG
(CHEMBL3754314)
Show SMILES COCc1ccc(s1)-c1ccc(cc1)S(=O)(=O)NC(C(C)C)P(O)(O)=O
Show InChI InChI=1S/C16H22NO6PS2/c1-11(2)16(24(18,19)20)17-26(21,22)14-7-4-12(5-8-14)15-9-6-13(25-15)10-23-3/h4-9,11,16-17H,10H2,1-3H3,(H2,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50500715
PNG
(CHEMBL3752826)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(C)s1)P(O)(O)=O
Show InChI InChI=1S/C15H20NO5PS2/c1-10(2)15(22(17,18)19)16-24(20,21)13-7-5-12(6-8-13)14-9-4-11(3)23-14/h4-10,15-16H,1-3H3,(H2,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP13 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
Neutrophil collagenase


(Homo sapiens (Human))		BDBM50500713
PNG
(CHEMBL3752747)
Show SMILES CC(C)C(NS(=O)(=O)c1ccc(cc1)-c1ccc(F)nc1)P(O)(O)=O
Show InChI InChI=1S/C15H18FN2O5PS/c1-10(2)15(24(19,20)21)18-25(22,23)13-6-3-11(4-7-13)12-5-8-14(16)17-9-12/h3-10,15,18H,1-2H3,(H2,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Westf£lische Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Inhibition of MMP8 (unknown origin) using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2...

Bioorg Med Chem 24: 902-9 (2016)


Article DOI: 10.1016/j.bmc.2016.01.017
BindingDB Entry DOI: 10.7270/Q2V69NKB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%