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PubMed code 26854379

Compile data set for download or QSAR
Found 96 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50072394
PNG
(1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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n/an/a 7n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50072394
PNG
(1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158394
PNG
(CHEMBL3780645)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C17H23IN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/a 69n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158418
PNG
(CHEMBL3780746)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C17H23BrN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158418
PNG
(CHEMBL3780746)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C17H23BrN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158394
PNG
(CHEMBL3780645)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C17H23IN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/a 324n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158395
PNG
(CHEMBL3782037)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C18H25IN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/a 1.18E+3n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158398
PNG
(CHEMBL3780633)
Show SMILES Cn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
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n/an/a 2.24E+3n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158395
PNG
(CHEMBL3782037)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C18H25IN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/a 2.45E+3n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158409
PNG
(CHEMBL3779931)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C18H25BrN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/a 7.60E+3n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158531
PNG
(CHEMBL3780248)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27ClN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/a 1.36E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158399
PNG
(CHEMBL3780802)
Show SMILES CCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C18H24I2N6O4/c1-2-25-14(19)10(24-18(25)20)8-11(23-16(29)9-5-6-13(27)22-9)17(30)26-7-3-4-12(26)15(21)28/h9,11-12H,2-8H2,1H3,(H2,21,28)(H,22,27)(H,23,29)/t9-,11-,12-/m0/s1
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n/an/a 1.56E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158409
PNG
(CHEMBL3779931)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C18H25BrN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/a 1.86E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158531
PNG
(CHEMBL3780248)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27ClN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/a 2.04E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158399
PNG
(CHEMBL3780802)
Show SMILES CCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C18H24I2N6O4/c1-2-25-14(19)10(24-18(25)20)8-11(23-16(29)9-5-6-13(27)22-9)17(30)26-7-3-4-12(26)15(21)28/h9,11-12H,2-8H2,1H3,(H2,21,28)(H,22,27)(H,23,29)/t9-,11-,12-/m0/s1
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n/an/a 2.93E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158398
PNG
(CHEMBL3780633)
Show SMILES Cn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
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n/an/a 4.80E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158392
PNG
(CHEMBL3781024)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158397
PNG
(CHEMBL3780836)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Cl)[nH]c1Cl)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20Cl2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158400
PNG
(CHEMBL3780191)
Show SMILES CCCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C19H26I2N6O4/c1-2-7-27-15(20)11(25-19(27)21)9-12(24-17(30)10-5-6-14(28)23-10)18(31)26-8-3-4-13(26)16(22)29/h10,12-13H,2-9H2,1H3,(H2,22,29)(H,23,28)(H,24,30)/t10-,12-,13-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158392
PNG
(CHEMBL3781024)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158400
PNG
(CHEMBL3780191)
Show SMILES CCCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C19H26I2N6O4/c1-2-7-27-15(20)11(25-19(27)21)9-12(24-17(30)10-5-6-14(28)23-10)18(31)26-8-3-4-13(26)16(22)29/h10,12-13H,2-9H2,1H3,(H2,22,29)(H,23,28)(H,24,30)/t10-,12-,13-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158396
PNG
(CHEMBL3781773)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27IN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158404
PNG
(CHEMBL3780373)
Show SMILES CCCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C19H27BrN6O4/c1-2-7-25-10-11(22-19(25)20)9-13(24-17(29)12-5-6-15(27)23-12)18(30)26-8-3-4-14(26)16(21)28/h10,12-14H,2-9H2,1H3,(H2,21,28)(H,23,27)(H,24,29)/t12-,13-,14-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158533
PNG
(CHEMBL3781873)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20I2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158397
PNG
(CHEMBL3780836)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Cl)[nH]c1Cl)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20Cl2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158532
PNG
(CHEMBL3781522)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Cl |r|
Show InChI InChI=1S/C17H23ClN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158532
PNG
(CHEMBL3781522)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Cl |r|
Show InChI InChI=1S/C17H23ClN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158404
PNG
(CHEMBL3780373)
Show SMILES CCCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C19H27BrN6O4/c1-2-7-25-10-11(22-19(25)20)9-13(24-17(29)12-5-6-15(27)23-12)18(30)26-8-3-4-14(26)16(21)28/h10,12-14H,2-9H2,1H3,(H2,21,28)(H,23,27)(H,24,29)/t12-,13-,14-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158401
PNG
(CHEMBL3780549)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H26I2N6O4/c24-19-15(29-23(25)31(19)12-13-5-2-1-3-6-13)11-16(28-21(34)14-8-9-18(32)27-14)22(35)30-10-4-7-17(30)20(26)33/h1-3,5-6,14,16-17H,4,7-12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,16-,17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R1 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158396
PNG
(CHEMBL3781773)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27IN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158533
PNG
(CHEMBL3781873)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20I2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158401
PNG
(CHEMBL3780549)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H26I2N6O4/c24-19-15(29-23(25)31(19)12-13-5-2-1-3-6-13)11-16(28-21(34)14-8-9-18(32)27-14)22(35)30-10-4-7-17(30)20(26)33/h1-3,5-6,14,16-17H,4,7-12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,16-,17-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50072394
PNG
(1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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n/an/an/an/a 3.20n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158395
PNG
(CHEMBL3782037)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C18H25IN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 0.100n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50072394
PNG
(1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158409
PNG
(CHEMBL3779931)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C18H25BrN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 1.05E+3n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158398
PNG
(CHEMBL3780633)
Show SMILES Cn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
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n/an/an/an/a 1n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158401
PNG
(CHEMBL3780549)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H26I2N6O4/c24-19-15(29-23(25)31(19)12-13-5-2-1-3-6-13)11-16(28-21(34)14-8-9-18(32)27-14)22(35)30-10-4-7-17(30)20(26)33/h1-3,5-6,14,16-17H,4,7-12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,16-,17-/m0/s1
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n/an/an/an/a 30n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158398
PNG
(CHEMBL3780633)
Show SMILES Cn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
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n/an/an/an/a 272n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158401
PNG
(CHEMBL3780549)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H26I2N6O4/c24-19-15(29-23(25)31(19)12-13-5-2-1-3-6-13)11-16(28-21(34)14-8-9-18(32)27-14)22(35)30-10-4-7-17(30)20(26)33/h1-3,5-6,14,16-17H,4,7-12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,16-,17-/m0/s1
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n/an/an/an/a 53n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158397
PNG
(CHEMBL3780836)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Cl)[nH]c1Cl)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20Cl2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a 5.97E+3n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158392
PNG
(CHEMBL3781024)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158409
PNG
(CHEMBL3779931)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C18H25BrN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 12n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158531
PNG
(CHEMBL3780248)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27ClN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 2.63E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158531
PNG
(CHEMBL3780248)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27ClN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 8.72E+3n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158400
PNG
(CHEMBL3780191)
Show SMILES CCCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C19H26I2N6O4/c1-2-7-27-15(20)11(25-19(27)21)9-12(24-17(30)10-5-6-14(28)23-10)18(31)26-8-3-4-13(26)16(22)29/h10,12-13H,2-9H2,1H3,(H2,22,29)(H,23,28)(H,24,30)/t10-,12-,13-/m0/s1
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n/an/an/an/a 206n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158532
PNG
(CHEMBL3781522)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Cl |r|
Show InChI InChI=1S/C17H23ClN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 320n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158394
PNG
(CHEMBL3780645)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C17H23IN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 5.90n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158401
PNG
(CHEMBL3780549)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H26I2N6O4/c24-19-15(29-23(25)31(19)12-13-5-2-1-3-6-13)11-16(28-21(34)14-8-9-18(32)27-14)22(35)30-10-4-7-17(30)20(26)33/h1-3,5-6,14,16-17H,4,7-12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,16-,17-/m0/s1
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n/an/an/an/a 15n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158399
PNG
(CHEMBL3780802)
Show SMILES CCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C18H24I2N6O4/c1-2-25-14(19)10(24-18(25)20)8-11(23-16(29)9-5-6-13(27)22-9)17(30)26-7-3-4-12(26)15(21)28/h9,11-12H,2-8H2,1H3,(H2,21,28)(H,22,27)(H,23,29)/t9-,11-,12-/m0/s1
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n/an/an/an/a 170n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158404
PNG
(CHEMBL3780373)
Show SMILES CCCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C19H27BrN6O4/c1-2-7-25-10-11(22-19(25)20)9-13(24-17(29)12-5-6-15(27)23-12)18(30)26-8-3-4-14(26)16(21)28/h10,12-14H,2-9H2,1H3,(H2,21,28)(H,23,27)(H,24,29)/t12-,13-,14-/m0/s1
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n/an/an/an/a 32n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158532
PNG
(CHEMBL3781522)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Cl |r|
Show InChI InChI=1S/C17H23ClN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 790n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158400
PNG
(CHEMBL3780191)
Show SMILES CCCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C19H26I2N6O4/c1-2-7-27-15(20)11(25-19(27)21)9-12(24-17(30)10-5-6-14(28)23-10)18(31)26-8-3-4-13(26)16(22)29/h10,12-13H,2-9H2,1H3,(H2,22,29)(H,23,28)(H,24,30)/t10-,12-,13-/m0/s1
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n/an/an/an/a 780n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158397
PNG
(CHEMBL3780836)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Cl)[nH]c1Cl)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20Cl2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a 360n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158392
PNG
(CHEMBL3781024)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158398
PNG
(CHEMBL3780633)
Show SMILES Cn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
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n/an/an/an/a 3.64E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158395
PNG
(CHEMBL3782037)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C18H25IN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158531
PNG
(CHEMBL3780248)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27ClN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 1.91E+3n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158392
PNG
(CHEMBL3781024)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158399
PNG
(CHEMBL3780802)
Show SMILES CCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C18H24I2N6O4/c1-2-25-14(19)10(24-18(25)20)8-11(23-16(29)9-5-6-13(27)22-9)17(30)26-7-3-4-12(26)15(21)28/h9,11-12H,2-8H2,1H3,(H2,21,28)(H,22,27)(H,23,29)/t9-,11-,12-/m0/s1
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n/an/an/an/a 12n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158396
PNG
(CHEMBL3781773)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27IN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 9n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158396
PNG
(CHEMBL3781773)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27IN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 27n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158392
PNG
(CHEMBL3781024)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Br)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27BrN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158533
PNG
(CHEMBL3781873)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20I2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158396
PNG
(CHEMBL3781773)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27IN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 27n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158532
PNG
(CHEMBL3781522)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Cl |r|
Show InChI InChI=1S/C17H23ClN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 87n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158404
PNG
(CHEMBL3780373)
Show SMILES CCCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C19H27BrN6O4/c1-2-7-25-10-11(22-19(25)20)9-13(24-17(29)12-5-6-15(27)23-12)18(30)26-8-3-4-14(26)16(21)28/h10,12-14H,2-9H2,1H3,(H2,21,28)(H,23,27)(H,24,29)/t12-,13-,14-/m0/s1
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n/an/an/an/a 1.68E+5n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50072394
PNG
(1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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n/an/an/an/a 3.10n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158397
PNG
(CHEMBL3780836)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Cl)[nH]c1Cl)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20Cl2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a 380n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158394
PNG
(CHEMBL3780645)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C17H23IN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 5n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158418
PNG
(CHEMBL3780746)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C17H23BrN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 3.40n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158404
PNG
(CHEMBL3780373)
Show SMILES CCCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C19H27BrN6O4/c1-2-7-25-10-11(22-19(25)20)9-13(24-17(29)12-5-6-15(27)23-12)18(30)26-8-3-4-14(26)16(21)28/h10,12-14H,2-9H2,1H3,(H2,21,28)(H,23,27)(H,24,29)/t12-,13-,14-/m0/s1
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n/an/an/an/a 2.56E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158418
PNG
(CHEMBL3780746)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C17H23BrN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 0.460n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158404
PNG
(CHEMBL3780373)
Show SMILES CCCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C19H27BrN6O4/c1-2-7-25-10-11(22-19(25)20)9-13(24-17(29)12-5-6-15(27)23-12)18(30)26-8-3-4-14(26)16(21)28/h10,12-14H,2-9H2,1H3,(H2,21,28)(H,23,27)(H,24,29)/t12-,13-,14-/m0/s1
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n/an/an/an/a 1.30n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158409
PNG
(CHEMBL3779931)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C18H25BrN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158400
PNG
(CHEMBL3780191)
Show SMILES CCCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C19H26I2N6O4/c1-2-7-27-15(20)11(25-19(27)21)9-12(24-17(30)10-5-6-14(28)23-10)18(31)26-8-3-4-13(26)16(22)29/h10,12-13H,2-9H2,1H3,(H2,22,29)(H,23,28)(H,24,30)/t10-,12-,13-/m0/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158396
PNG
(CHEMBL3781773)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(I)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27IN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 339n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158533
PNG
(CHEMBL3781873)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20I2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158394
PNG
(CHEMBL3780645)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C17H23IN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 0.400n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Displacement of [3H]-Me-His-TRH from mouse TRH-R2 expressed in HEK293 cells preincubated for 15 mins measured after 4 hrs


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158399
PNG
(CHEMBL3780802)
Show SMILES CCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C18H24I2N6O4/c1-2-25-14(19)10(24-18(25)20)8-11(23-16(29)9-5-6-13(27)22-9)17(30)26-7-3-4-12(26)15(21)28/h9,11-12H,2-8H2,1H3,(H2,21,28)(H,22,27)(H,23,29)/t9-,11-,12-/m0/s1
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n/an/an/an/a 38n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158397
PNG
(CHEMBL3780836)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(Cl)[nH]c1Cl)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20Cl2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a 1.29E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158409
PNG
(CHEMBL3779931)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C18H25BrN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 1.83E+3n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158399
PNG
(CHEMBL3780802)
Show SMILES CCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C18H24I2N6O4/c1-2-25-14(19)10(24-18(25)20)8-11(23-16(29)9-5-6-13(27)22-9)17(30)26-7-3-4-12(26)15(21)28/h9,11-12H,2-8H2,1H3,(H2,21,28)(H,22,27)(H,23,29)/t9-,11-,12-/m0/s1
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n/an/an/an/a 249n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158533
PNG
(CHEMBL3781873)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20I2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158418
PNG
(CHEMBL3780746)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C17H23BrN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158531
PNG
(CHEMBL3780248)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cn(Cc2ccccc2)c(Cl)n1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H27ClN6O4/c24-23-26-15(13-29(23)12-14-5-2-1-3-6-14)11-17(28-21(33)16-8-9-19(31)27-16)22(34)30-10-4-7-18(30)20(25)32/h1-3,5-6,13,16-18H,4,7-12H2,(H2,25,32)(H,27,31)(H,28,33)/t16-,17-,18-/m0/s1
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n/an/an/an/a 1.57E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158533
PNG
(CHEMBL3781873)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)[nH]c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H20I2N6O4/c17-12-8(22-16(18)23-12)6-9(21-14(27)7-3-4-11(25)20-7)15(28)24-5-1-2-10(24)13(19)26/h7,9-10H,1-6H2,(H2,19,26)(H,20,25)(H,21,27)(H,22,23)/t7-,9-,10-/m0/s1
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n/an/an/an/a>5.00E+4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158395
PNG
(CHEMBL3782037)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C18H25IN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 4.90n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50072394
PNG
(1-[3-(1H-4-imidazolyl)-2-(5-oxotetrahydro-1H-2-pyr...)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
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n/an/an/an/a 0.5n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as Ca2+ release by FLIPR assay


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158532
PNG
(CHEMBL3781522)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Cl |r|
Show InChI InChI=1S/C17H23ClN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 51n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158394
PNG
(CHEMBL3780645)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C17H23IN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 31n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(MOUSE)
BDBM50158418
PNG
(CHEMBL3780746)
Show SMILES Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r|
Show InChI InChI=1S/C17H23BrN6O4/c1-23-8-9(20-17(23)18)7-11(22-15(27)10-4-5-13(25)21-10)16(28)24-6-2-3-12(24)14(19)26/h8,10-12H,2-7H2,1H3,(H2,19,26)(H,21,25)(H,22,27)/t10-,11-,12-/m0/s1
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n/an/an/an/a 28n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R1 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158400
PNG
(CHEMBL3780191)
Show SMILES CCCn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C19H26I2N6O4/c1-2-7-27-15(20)11(25-19(27)21)9-12(24-17(30)10-5-6-14(28)23-10)18(31)26-8-3-4-13(26)16(22)29/h10,12-13H,2-9H2,1H3,(H2,22,29)(H,23,28)(H,24,30)/t10-,12-,13-/m0/s1
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n/an/an/an/a 350n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158401
PNG
(CHEMBL3780549)
Show SMILES NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)[C@@H]1CCC(=O)N1 |r|
Show InChI InChI=1S/C23H26I2N6O4/c24-19-15(29-23(25)31(19)12-13-5-2-1-3-6-13)11-16(28-21(34)14-8-9-18(32)27-14)22(35)30-10-4-7-17(30)20(26)33/h1-3,5-6,14,16-17H,4,7-12H2,(H2,26,33)(H,27,32)(H,28,34)/t14-,16-,17-/m0/s1
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n/an/an/an/a 9n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158398
PNG
(CHEMBL3780633)
Show SMILES Cn1c(I)nc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)c1I |r|
Show InChI InChI=1S/C17H22I2N6O4/c1-24-13(18)9(23-17(24)19)7-10(22-15(28)8-4-5-12(26)21-8)16(29)25-6-2-3-11(25)14(20)27/h8,10-11H,2-7H2,1H3,(H2,20,27)(H,21,26)(H,22,28)/t8-,10-,11-/m0/s1
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n/an/an/an/a 39n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
Thyrotropin-releasing hormone receptor


(Mus musculus)
BDBM50158395
PNG
(CHEMBL3782037)
Show SMILES CCn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1I |r|
Show InChI InChI=1S/C18H25IN6O4/c1-2-24-9-10(21-18(24)19)8-12(23-16(28)11-5-6-14(26)22-11)17(29)25-7-3-4-13(25)15(20)27/h9,11-13H,2-8H2,1H3,(H2,20,27)(H,22,26)(H,23,28)/t11-,12-,13-/m0/s1
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n/an/an/an/a 4n/an/an/an/a



National Institute of Pharmaceutical Education and Research

Curated by ChEMBL


Assay Description
Agonist activity at mouse TRH-R2 expressed in HEK293 cells assessed as IP1 formation after 1 hr by ELISA


Eur J Med Chem 111: 72-83 (2016)


Article DOI: 10.1016/j.ejmech.2016.01.038
BindingDB Entry DOI: 10.7270/Q28G8NKF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%