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PubMed code 26883149

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50152098
PNG
(CHEMBL3780654)
Show SMILES CC1=NN(C(C1)c1ccccc1O)C(=O)C(F)(F)F |t:1|
Show InChI InChI=1S/C12H11F3N2O2/c1-7-6-9(8-4-2-3-5-10(8)18)17(16-7)11(19)12(13,14)15/h2-5,9,18H,6H2,1H3
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Article
PubMed
n/an/a 1.86E+3n/an/an/an/an/an/a



Hefei University of Technology

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method


Bioorg Med Chem Lett 26: 1508-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.025
BindingDB Entry DOI: 10.7270/Q2833TX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50105463
PNG
(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)
Show SMILES CCn1c(-c2ccccc2)c2cc(N)ccc2c2ccc(=[NH2+])cc12
Show InChI InChI=1S/C21H19N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,23H,2,22H2,1H3/p+1
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Article
PubMed
n/an/a 2.18E+3n/an/an/an/an/an/a



Hefei University of Technology

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method


Bioorg Med Chem Lett 26: 1508-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.025
BindingDB Entry DOI: 10.7270/Q2833TX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50152096
PNG
(CHEMBL3782024)
Show SMILES CC1=NN(C(C1)c1ccccc1O)C(=O)CF |t:1|
Show InChI InChI=1S/C12H13FN2O2/c1-8-6-10(15(14-8)12(17)7-13)9-4-2-3-5-11(9)16/h2-5,10,16H,6-7H2,1H3
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PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Hefei University of Technology

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method


Bioorg Med Chem Lett 26: 1508-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.025
BindingDB Entry DOI: 10.7270/Q2833TX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50152099
PNG
(CHEMBL3781107)
Show SMILES COc1ccc(cc1)C(=O)N1N=C(C)CC1c1ccccc1O |t:12|
Show InChI InChI=1S/C18H18N2O3/c1-12-11-16(15-5-3-4-6-17(15)21)20(19-12)18(22)13-7-9-14(23-2)10-8-13/h3-10,16,21H,11H2,1-2H3
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PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Hefei University of Technology

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method


Bioorg Med Chem Lett 26: 1508-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.025
BindingDB Entry DOI: 10.7270/Q2833TX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50152100
PNG
(CHEMBL3781523)
Show SMILES CC1=NN(C(C1)c1ccccc1O)C(=O)c1ccc(F)cc1 |t:1|
Show InChI InChI=1S/C17H15FN2O2/c1-11-10-15(14-4-2-3-5-16(14)21)20(19-11)17(22)12-6-8-13(18)9-7-12/h2-9,15,21H,10H2,1H3
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Article
PubMed
n/an/a 2.98E+4n/an/an/an/an/an/a



Hefei University of Technology

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method


Bioorg Med Chem Lett 26: 1508-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.025
BindingDB Entry DOI: 10.7270/Q2833TX9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50152101
PNG
(CHEMBL3780707)
Show SMILES CC1=NN(C(C1)c1cc(Br)ccc1O)S(=O)(=O)c1ccc(cc1)C(F)(F)F |t:1|
Show InChI InChI=1S/C17H14BrF3N2O3S/c1-10-8-15(14-9-12(18)4-7-16(14)24)23(22-10)27(25,26)13-5-2-11(3-6-13)17(19,20)21/h2-7,9,15,24H,8H2,1H3
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Article
PubMed
n/an/a>6.00E+4n/an/an/an/an/an/a



Hefei University of Technology

Curated by ChEMBL


Assay Description
Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method


Bioorg Med Chem Lett 26: 1508-11 (2016)


Article DOI: 10.1016/j.bmcl.2016.02.025
BindingDB Entry DOI: 10.7270/Q2833TX9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%