Found 6 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50152098
(CHEMBL3780654)Show InChI InChI=1S/C12H11F3N2O2/c1-7-6-9(8-4-2-3-5-10(8)18)17(16-7)11(19)12(13,14)15/h2-5,9,18H,6H2,1H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method |
Bioorg Med Chem Lett 26: 1508-11 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 |
More data for this Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50105463
(2,7-diamino-10-ethyl-9-phenylphenanthridinium brom...)Show SMILES CCn1c(-c2ccccc2)c2cc(N)ccc2c2ccc(=[NH2+])cc12 Show InChI InChI=1S/C21H19N3/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14/h3-13,23H,2,22H2,1H3/p+1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method |
Bioorg Med Chem Lett 26: 1508-11 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 |
More data for this Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50152096
(CHEMBL3782024)Show InChI InChI=1S/C12H13FN2O2/c1-8-6-10(15(14-8)12(17)7-13)9-4-2-3-5-11(9)16/h2-5,10,16H,6-7H2,1H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method |
Bioorg Med Chem Lett 26: 1508-11 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 |
More data for this Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50152099
(CHEMBL3781107)Show SMILES COc1ccc(cc1)C(=O)N1N=C(C)CC1c1ccccc1O |t:12| Show InChI InChI=1S/C18H18N2O3/c1-12-11-16(15-5-3-4-6-17(15)21)20(19-12)18(22)13-7-9-14(23-2)10-8-13/h3-10,16,21H,11H2,1-2H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method |
Bioorg Med Chem Lett 26: 1508-11 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 |
More data for this Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50152100
(CHEMBL3781523)Show SMILES CC1=NN(C(C1)c1ccccc1O)C(=O)c1ccc(F)cc1 |t:1| Show InChI InChI=1S/C17H15FN2O2/c1-11-10-15(14-4-2-3-5-16(14)21)20(19-11)17(22)12-6-8-13(18)9-7-12/h2-9,15,21H,10H2,1H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method |
Bioorg Med Chem Lett 26: 1508-11 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 |
More data for this Ligand-Target Pair | |
Telomerase reverse transcriptase
(Homo sapiens (Human)) | BDBM50152101
(CHEMBL3780707)Show SMILES CC1=NN(C(C1)c1cc(Br)ccc1O)S(=O)(=O)c1ccc(cc1)C(F)(F)F |t:1| Show InChI InChI=1S/C17H14BrF3N2O3S/c1-10-8-15(14-9-12(18)4-7-16(14)24)23(22-10)27(25,26)13-5-2-11(3-6-13)17(19,20)21/h2-7,9,15,24H,8H2,1H3 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hefei University of Technology
Curated by ChEMBL
| Assay Description Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method |
Bioorg Med Chem Lett 26: 1508-11 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.025 BindingDB Entry DOI: 10.7270/Q2833TX9 |
More data for this Ligand-Target Pair | |