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PubMed code 26901666

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161874
PNG
(CHEMBL3794475)
Show SMILES CCN(CC)c1ccc(C)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27ClN4O/c1-7-26(8-2)16-10-9-13(3)19-20(16)25(5)21(24-19)23-18-14(4)11-15(22)12-17(18)27-6/h9-12H,7-8H2,1-6H3,(H,23,24)
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n/an/a 7.60n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50116105
PNG
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)|
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
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n/an/a 8.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161832
PNG
(CHEMBL3792517)
Show SMILES CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H28Cl2N4O/c1-6-10-28(11-7-2)17-9-8-16(24)20-21(17)27(4)22(26-20)25-19-14(3)12-15(23)13-18(19)29-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,25,26)
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n/an/a 9.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161862
PNG
(CHEMBL3793568)
Show SMILES Cl.CCN(C(C)C)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27BrN4O.ClH/c1-7-26(13(2)3)17-10-8-9-16-20(17)25(5)21(23-16)24-19-14(4)11-15(22)12-18(19)27-6;/h8-13H,7H2,1-6H3,(H,23,24);1H
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161858
PNG
(CHEMBL3793367)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C22H29BrN4O.ClH/c1-6-11-27(12-7-2)18-10-8-9-17-21(18)26(4)22(24-17)25-20-15(3)13-16(23)14-19(20)28-5;/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25);1H
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161958
PNG
(CHEMBL3794479)
Show SMILES CCN(CC)c1ccc(OC)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27ClN4O2/c1-7-26(8-2)15-9-10-16(27-5)19-20(15)25(4)21(24-19)23-18-13(3)11-14(22)12-17(18)28-6/h9-12H,7-8H2,1-6H3,(H,23,24)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161868
PNG
(CHEMBL3793070)
Show SMILES CCN(CC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H24ClN5O/c1-6-27(7-2)16-9-8-14(12-23)19-20(16)26(4)21(25-19)24-18-13(3)10-15(22)11-17(18)28-5/h8-11H,6-7H2,1-5H3,(H,24,25)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161860
PNG
(CHEMBL3793322)
Show SMILES Cl.CCN(CC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C20H25BrN4O.ClH/c1-6-25(7-2)16-10-8-9-15-19(16)24(4)20(22-15)23-18-13(3)11-14(21)12-17(18)26-5;/h8-12H,6-7H2,1-5H3,(H,22,23);1H
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161861
PNG
(CHEMBL3792935)
Show SMILES Cl.CCCCN(CCCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C24H33BrN4O.ClH/c1-6-8-13-29(14-9-7-2)20-12-10-11-19-23(20)28(4)24(26-19)27-22-17(3)15-18(25)16-21(22)30-5;/h10-12,15-16H,6-9,13-14H2,1-5H3,(H,26,27);1H
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161841
PNG
(CHEMBL3793985)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H29ClN4O/c1-6-11-27(12-7-2)18-10-8-9-17-21(18)26(4)22(24-17)25-20-15(3)13-16(23)14-19(20)28-5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161866
PNG
(CHEMBL3794030)
Show SMILES CCCN(CCC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C23H28ClN5O/c1-6-10-29(11-7-2)18-9-8-16(14-25)21-22(18)28(4)23(27-21)26-20-15(3)12-17(24)13-19(20)30-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,26,27)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161854
PNG
(CHEMBL3794051)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C)c12
Show InChI InChI=1S/C23H32N4/c1-7-12-27(13-8-2)20-11-9-10-19-22(20)26(6)23(24-19)25-21-17(4)14-16(3)15-18(21)5/h9-11,14-15H,7-8,12-13H2,1-6H3,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161859
PNG
(CHEMBL3792636)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3C(C)C)n(C)c12
Show InChI InChI=1S/C24H33ClN4.ClH/c1-7-12-29(13-8-2)21-11-9-10-20-23(21)28(6)24(26-20)27-22-17(5)14-18(25)15-19(22)16(3)4;/h9-11,14-16H,7-8,12-13H2,1-6H3,(H,26,27);1H
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n/an/a 22n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161867
PNG
(CHEMBL3793277)
Show SMILES CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C20H24Cl2N4O/c1-6-26(7-2)15-9-8-14(22)18-19(15)25(4)20(24-18)23-17-12(3)10-13(21)11-16(17)27-5/h8-11H,6-7H2,1-5H3,(H,23,24)
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n/an/a 24n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161863
PNG
(CHEMBL3793560)
Show SMILES COCCN(CCOC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C22H29BrN4O3/c1-15-13-16(23)14-19(30-5)20(15)25-22-24-17-7-6-8-18(21(17)26(22)2)27(9-11-28-3)10-12-29-4/h6-8,13-14H,9-12H2,1-5H3,(H,24,25)
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n/an/a 65n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161856
PNG
(CHEMBL3793190)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)sc12
Show InChI InChI=1S/C22H29N3S/c1-6-11-25(12-7-2)19-10-8-9-18-21(19)26-22(23-18)24-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,23,24)
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n/an/a 77n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161851
PNG
(CHEMBL3793744)
Show SMILES OC(=O)C(F)(F)F.CCCN(CCC)c1cccc2nc(Nc3ccc(C)cc3C)n(C)c12
Show InChI InChI=1S/C22H30N4.C2HF3O2/c1-6-13-26(14-7-2)20-10-8-9-19-21(20)25(5)22(24-19)23-18-12-11-16(3)15-17(18)4;3-2(4,5)1(6)7/h8-12,15H,6-7,13-14H2,1-5H3,(H,23,24);(H,6,7)
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n/an/a 84n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161832
PNG
(CHEMBL3792517)
Show SMILES CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H28Cl2N4O/c1-6-10-28(11-7-2)17-9-8-16(24)20-21(17)27(4)22(26-20)25-19-14(3)12-15(23)13-18(19)29-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,25,26)
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n/an/a 88n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-stimulated cAMP accumulation after 4 hrs by steady-gl...

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161853
PNG
(CHEMBL3793781)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C(C)C)c12
Show InChI InChI=1S/C25H36N4/c1-8-13-28(14-9-2)22-12-10-11-21-24(22)29(17(3)4)25(26-21)27-23-19(6)15-18(5)16-20(23)7/h10-12,15-17H,8-9,13-14H2,1-7H3,(H,26,27)
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n/an/a 97n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161844
PNG
(CHEMBL3793329)
Show SMILES OC(=O)C(F)(F)F.CCCN(CCC)c1cccc2nc(Nc3c(C)cccc3C)n(C)c12
Show InChI InChI=1S/C22H30N4.C2HF3O2/c1-6-14-26(15-7-2)19-13-9-12-18-21(19)25(5)22(23-18)24-20-16(3)10-8-11-17(20)4;3-2(4,5)1(6)7/h8-13H,6-7,14-15H2,1-5H3,(H,23,24);(H,6,7)
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n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161864
PNG
(CHEMBL3794050)
Show SMILES CCCN(CCC)c1c(Cl)cc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H27Cl3N4O/c1-6-8-29(9-7-2)20-16(25)12-15(24)19-21(20)28(4)22(27-19)26-18-13(3)10-14(23)11-17(18)30-5/h10-12H,6-9H2,1-5H3,(H,26,27)
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n/an/a 170n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161857
PNG
(CHEMBL3793059)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)oc12
Show InChI InChI=1S/C22H29N3O/c1-6-11-25(12-7-2)19-10-8-9-18-21(19)26-22(23-18)24-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,23,24)
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n/an/a 990n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161852
PNG
(CHEMBL3793751)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(-c3ccccc3)c12
Show InChI InChI=1S/C28H34N4.ClH/c1-6-16-31(17-7-2)25-15-11-14-24-27(25)32(23-12-9-8-10-13-23)28(29-24)30-26-21(4)18-20(3)19-22(26)5;/h8-15,18-19H,6-7,16-17H2,1-5H3,(H,29,30);1H
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n/an/a 2.20E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161855
PNG
(CHEMBL3793362)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)[nH]c12
Show InChI InChI=1S/C22H30N4.ClH/c1-6-11-26(12-7-2)19-10-8-9-18-21(19)25-22(23-18)24-20-16(4)13-15(3)14-17(20)5;/h8-10,13-14H,6-7,11-12H2,1-5H3,(H2,23,24,25);1H
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n/an/a 2.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161865
PNG
(CHEMBL3793845)
Show SMILES CCCN(CCC)c1c(Cl)ccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H28Cl2N4O/c1-6-10-28(11-7-2)20-16(24)8-9-17-21(20)27(4)22(25-17)26-19-14(3)12-15(23)13-18(19)29-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161925
PNG
(CHEMBL3793159)
Show SMILES CCN(CC)c1ccc(-c2ccccc2)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C26H29ClN4O/c1-6-31(7-2)21-14-13-20(18-11-9-8-10-12-18)24-25(21)30(4)26(29-24)28-23-17(3)15-19(27)16-22(23)32-5/h8-16H,6-7H2,1-5H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%