Affinity Data by PubMed id=26996373

PubMed code 26996373

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (RAT)	BDBM78940 (METHIOTHEPIN \| MLS000859918 \| Methiothepin mesylat...) Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Guanajuato Curated by ChEMBL					Assay Description Displacement of [3H]-LSD from rat 5-Ht6 receptor expressed in HEK cells after 60 mins by liquid scintillation counting				Bioorg Med Chem Lett 26: 2333-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.036 BindingDB Entry DOI: 10.7270/Q20R9SDH
Universidad de Guanajuato Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM10755 (14C-5-hydroxy tryptamine creatinine disulfate \| 2-...) Show SMILES NCCc1c[nH]c2ccc(O)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Guanajuato Curated by ChEMBL					Assay Description Binding affinity to 5-Ht6 receptor (unknown origin)				Bioorg Med Chem Lett 26: 2333-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.036 BindingDB Entry DOI: 10.7270/Q20R9SDH
Universidad de Guanajuato Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 6 (RAT)	BDBM78940 (METHIOTHEPIN \| MLS000859918 \| Methiothepin mesylat...) Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Guanajuato Curated by ChEMBL					Assay Description Displacement of [3H]-LSD from recombinant rat 5-Ht6 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting				Bioorg Med Chem Lett 26: 2333-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.036 BindingDB Entry DOI: 10.7270/Q20R9SDH
Universidad de Guanajuato Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (RAT)	BDBM78940 (METHIOTHEPIN \| MLS000859918 \| Methiothepin mesylat...) Show SMILES CSc1ccc2Sc3ccccc3CC(N3CCN(C)CC3)c2c1 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Guanajuato Curated by ChEMBL					Assay Description Displacement of [3H]-5HT from recombinant rat 5-Ht6 receptor expressed in HEK293 cells after 120 mins by liquid scintillation counting				Bioorg Med Chem Lett 26: 2333-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.036 BindingDB Entry DOI: 10.7270/Q20R9SDH
Universidad de Guanajuato Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (RAT)	BDBM50500913 (CHEMBL3799903) Show SMILES Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	211	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universidad de Guanajuato Curated by ChEMBL					Assay Description Displacement of [3H]-LSD from rat 5-Ht6 receptor expressed in HEK cells after 60 mins by liquid scintillation counting				Bioorg Med Chem Lett 26: 2333-8 (2016) Article DOI: 10.1016/j.bmcl.2016.03.036 BindingDB Entry DOI: 10.7270/Q20R9SDH
Universidad de Guanajuato Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%