Found 25 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158548
(CHEMBL3781511)Show SMILES NC1=C(C(=O)CN1c1cccc(O)c1)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H14N4O2/c18-16-15(17-19-12-6-1-2-7-13(12)20-17)14(23)9-21(16)10-4-3-5-11(22)8-10/h1-8,22H,9,18H2,(H,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158540
(CHEMBL3781099)Show SMILES COc1ccc(Cl)cc1N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:14| Show InChI InChI=1S/C18H15ClN4O2/c1-25-15-7-6-10(19)8-13(15)23-9-14(24)16(17(23)20)18-21-11-4-2-3-5-12(11)22-18/h2-8H,9,20H2,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158547
(CHEMBL3781980)Show SMILES Cc1ccc2nc([nH]c2c1)C1=C(N)N(CC1=O)c1cccc(O)c1 |c:12| Show InChI InChI=1S/C18H16N4O2/c1-10-5-6-13-14(7-10)21-18(20-13)16-15(24)9-22(17(16)19)11-3-2-4-12(23)8-11/h2-8,23H,9,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158541
(CHEMBL3781649)Show SMILES NC1=C(C(=O)CN1c1cccc(Cl)c1)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H13ClN4O/c18-10-4-3-5-11(8-10)22-9-14(23)15(16(22)19)17-20-12-6-1-2-7-13(12)21-17/h1-8H,9,19H2,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158360
(CHEMBL3779986)Show SMILES Cc1ccc2nc([nH]c2c1)C1=C(N)N(CC1=O)c1cccc(Cl)c1 |c:12| Show InChI InChI=1S/C18H15ClN4O/c1-10-5-6-13-14(7-10)22-18(21-13)16-15(24)9-23(17(16)20)12-4-2-3-11(19)8-12/h2-8H,9,20H2,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158543
(CHEMBL3780362)Show SMILES NC1=C(C(=O)CN1c1ccc(O)cc1)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H14N4O2/c18-16-15(17-19-12-3-1-2-4-13(12)20-17)14(23)9-21(16)10-5-7-11(22)8-6-10/h1-8,22H,9,18H2,(H,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158545
(CHEMBL3780482)Show SMILES Cc1ccc(cc1O)N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:13| Show InChI InChI=1S/C18H16N4O2/c1-10-6-7-11(8-14(10)23)22-9-15(24)16(17(22)19)18-20-12-4-2-3-5-13(12)21-18/h2-8,23H,9,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158576
(CHEMBL3780825)Show SMILES COc1ccc(OC)c(c1)N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:15| Show InChI InChI=1S/C19H18N4O3/c1-25-11-7-8-16(26-2)14(9-11)23-10-15(24)17(18(23)20)19-21-12-5-3-4-6-13(12)22-19/h3-9H,10,20H2,1-2H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158549
(CHEMBL3782011)Show SMILES COc1cccc(c1)N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:13| Show InChI InChI=1S/C18H16N4O2/c1-24-12-6-4-5-11(9-12)22-10-15(23)16(17(22)19)18-20-13-7-2-3-8-14(13)21-18/h2-9H,10,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158546
(CHEMBL3780794)Show SMILES Cn1c(nc2ccccc12)C1=C(N)N(CC1=O)c1cccc(O)c1 |c:12| Show InChI InChI=1S/C18H16N4O2/c1-21-14-8-3-2-7-13(14)20-18(21)16-15(24)10-22(17(16)19)11-5-4-6-12(23)9-11/h2-9,23H,10,19H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158574
(CHEMBL3781238)Show SMILES COc1ccc(cc1)N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:13| Show InChI InChI=1S/C18H16N4O2/c1-24-12-8-6-11(7-9-12)22-10-15(23)16(17(22)19)18-20-13-4-2-3-5-14(13)21-18/h2-9H,10,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158361
(CHEMBL3779927)Show SMILES Cc1ccc2nc([nH]c2c1)C1=C(N)N(CC1=O)c1cccc(F)c1 |c:12| Show InChI InChI=1S/C18H15FN4O/c1-10-5-6-13-14(7-10)22-18(21-13)16-15(24)9-23(17(16)20)12-4-2-3-11(19)8-12/h2-8H,9,20H2,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158573
(CHEMBL3781175)Show SMILES COc1ccccc1N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:13| Show InChI InChI=1S/C18H16N4O2/c1-24-15-9-5-4-8-13(15)22-10-14(23)16(17(22)19)18-20-11-6-2-3-7-12(11)21-18/h2-9H,10,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158367
(CHEMBL3780105)Show SMILES NC1=C(C(=O)CN1c1cccc(c1)C(F)(F)F)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C18H13F3N4O/c19-18(20,21)10-4-3-5-11(8-10)25-9-14(26)15(16(25)22)17-23-12-6-1-2-7-13(12)24-17/h1-8H,9,22H2,(H,23,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158539
(CHEMBL3780392)Show SMILES COc1ccc(C)cc1N1CC(=O)C(=C1N)c1nc2ccc(C)cc2[nH]1 |c:14| Show InChI InChI=1S/C20H20N4O2/c1-11-4-6-13-14(8-11)23-20(22-13)18-16(25)10-24(19(18)21)15-9-12(2)5-7-17(15)26-3/h4-9H,10,21H2,1-3H3,(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158544
(CHEMBL3781192)Show SMILES Cn1c(nc2ccccc12)C1=C(N)N(CC1=O)c1ccc(O)cc1 |c:12| Show InChI InChI=1S/C18H16N4O2/c1-21-14-5-3-2-4-13(14)20-18(21)16-15(24)10-22(17(16)19)11-6-8-12(23)9-7-11/h2-9,23H,10,19H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158366
(CHEMBL1457887)Show SMILES NC1=C(C(=O)CN1c1ccc(F)cc1)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H13FN4O/c18-10-5-7-11(8-6-10)22-9-14(23)15(16(22)19)17-20-12-3-1-2-4-13(12)21-17/h1-8H,9,19H2,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158364
(CHEMBL3779960)Show SMILES Cc1ccc2nc([nH]c2c1)C1=C(N)N(CC1=O)c1ccc(Cl)cc1 |c:12| Show InChI InChI=1S/C18H15ClN4O/c1-10-2-7-13-14(8-10)22-18(21-13)16-15(24)9-23(17(16)20)12-5-3-11(19)4-6-12/h2-8H,9,20H2,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158575
(CHEMBL3781689)Show SMILES CCOc1ccccc1N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:14| Show InChI InChI=1S/C19H18N4O2/c1-2-25-16-10-6-5-9-14(16)23-11-15(24)17(18(23)20)19-21-12-7-3-4-8-13(12)22-19/h3-10H,2,11,20H2,1H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158542
(CHEMBL1605162)Show SMILES NC1=C(C(=O)CN1c1ccccc1)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H14N4O/c18-16-15(17-19-12-8-4-5-9-13(12)20-17)14(22)10-21(16)11-6-2-1-3-7-11/h1-9H,10,18H2,(H,19,20) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158572
(CHEMBL3781563)Show SMILES Cc1ccc(cc1)N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:12| Show InChI InChI=1S/C18H16N4O/c1-11-6-8-12(9-7-11)22-10-15(23)16(17(22)19)18-20-13-4-2-3-5-14(13)21-18/h2-9H,10,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158363
(CHEMBL3780837)Show SMILES NC1=C(C(=O)CN1c1ccccc1F)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H13FN4O/c18-10-5-1-4-8-13(10)22-9-14(23)15(16(22)19)17-20-11-6-2-3-7-12(11)21-17/h1-8H,9,19H2,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158362
(CHEMBL3781089)Show SMILES NC1=C(C(=O)CN1c1ccccc1Cl)c1nc2ccccc2[nH]1 |t:1| Show InChI InChI=1S/C17H13ClN4O/c18-10-5-1-4-8-13(10)22-9-14(23)15(16(22)19)17-20-11-6-2-3-7-12(11)21-17/h1-8H,9,19H2,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158577
(CHEMBL3781310)Show SMILES COc1ccc(N2CC(=O)C(=C2N)c2nc3ccccc3[nH]2)c(OC)c1 |c:10| Show InChI InChI=1S/C19H18N4O3/c1-25-11-7-8-14(16(9-11)26-2)23-10-15(24)17(18(23)20)19-21-12-5-3-4-6-13(12)22-19/h3-9H,10,20H2,1-2H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50158550
(CHEMBL3780849)Show SMILES Cc1cccc(c1)N1CC(=O)C(=C1N)c1nc2ccccc2[nH]1 |c:12| Show InChI InChI=1S/C18H16N4O/c1-11-5-4-6-12(9-11)22-10-15(23)16(17(22)19)18-20-13-7-2-3-8-14(13)21-18/h2-9H,10,19H2,1H3,(H,20,21) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected insect Sf21 cells after 25 mins u... |
Bioorg Med Chem 24: 2053-9 (2016)
Article DOI: 10.1016/j.bmc.2016.03.036
BindingDB Entry DOI: 10.7270/Q2D50PVJ |
More data for this
Ligand-Target Pair | |
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