Affinity Data by PubMed id=27020050

PubMed code 27020050

Found 19 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transthyretin (Homo sapiens (Human))	BDBM50410534 (CHEMBL83116) Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cc(Cl)c(O)c(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50410534 (CHEMBL83116) Show SMILES Oc1c(Cl)cc(cc1Cl)-c1cc(Cl)c(O)c(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197882 (CHEMBL3959466) Show SMILES Cc1c(\C=C\c2ccc(Cl)o2)occ1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.02E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197882 (CHEMBL3959466) Show SMILES Cc1c(\C=C\c2ccc(Cl)o2)occ1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.04E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50301375 (3,3',5,5'-tetraiodo-L-thyronine \| 3,5,3',5'-tetrai...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.19E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50301375 (3,3',5,5'-tetraiodo-L-thyronine \| 3,5,3',5'-tetrai...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197881 (CHEMBL3890392) Show SMILES Cc1oc(\C=C\c2ccc(Cl)o2)cc1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197881 (CHEMBL3890392) Show SMILES Cc1oc(\C=C\c2ccc(Cl)o2)cc1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197884 (CHEMBL3969733) Show SMILES Cc1oc(CSCc2cc(C(O)=O)c(C)o2)cc1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197882 (CHEMBL3959466) Show SMILES Cc1c(\C=C\c2ccc(Cl)o2)occ1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	357	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197881 (CHEMBL3890392) Show SMILES Cc1oc(\C=C\c2ccc(Cl)o2)cc1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197882 (CHEMBL3959466) Show SMILES Cc1c(\C=C\c2ccc(Cl)o2)occ1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	274	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for first binding sit...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197885 (CHEMBL3940890) Show SMILES Cc1n[nH]c(C)c1CCCOc1cc(ccc1F)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	314	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to human plasma wild type TTR assessed as dissociation constants for first binding site of TTR by isothermal titration calorimetric ...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50197881 (CHEMBL3890392) Show SMILES Cc1oc(\C=C\c2ccc(Cl)o2)cc1C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	278	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as dissociation constants for second binding si...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197885 (CHEMBL3940890) Show SMILES Cc1n[nH]c(C)c1CCCOc1cc(ccc1F)C(O)=O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a
Universidade de Coimbra Curated by ChEMBL					Assay Description Binding affinity to human plasma wild type TTR assessed as dissociation constants for second binding site of TTR by isothermal titration calorimetric...				Eur J Med Chem 121: 823-840 (2016) Article DOI: 10.1016/j.ejmech.2016.02.074 BindingDB Entry DOI: 10.7270/Q26975JG
Universidade de Coimbra Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%