Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Farnesyl pyrophosphate synthase (Homo sapiens (Human)) | BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Academia Sinica | Assay Description To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ... | Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
IspB protein (Escherichia coli (Enterobacteria)) | BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Academia Sinica | Assay Description The assays were performed by mixing either 0.2 μM E. coli OPPS, Y107A/F108A S. cerevisiae GGPPS, or Y96A/F97A human GGPPS with various concentra... | Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
IspB protein (Escherichia coli (Enterobacteria)) | BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Academia Sinica | Assay Description To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ... | Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast)) | BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Academia Sinica | Assay Description To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ... | Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Geranylgeranyl pyrophosphate synthase BTS1 [Y107A,F108A] (Saccharomyces cerevisiae (Yeast)) | BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Academia Sinica | Assay Description The assays were performed by mixing either 0.2 μM E. coli OPPS, Y107A/F108A S. cerevisiae GGPPS, or Y96A/F97A human GGPPS with various concentra... | Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Geranylgeranyl pyrophosphate synthase (Homo sapiens (Human)) | BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Academia Sinica | Assay Description To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ... | Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |