Affinity Data by PubMed id=27541261

PubMed code 27541261

Found 6 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transthyretin (Homo sapiens (Human))	BDBM50206384 (CHEMBL3917629) Show SMILES Cc1cc(\C=C\c2cc3ccc(O)cc3nc2Cl)cc(C)c1O Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...				Eur J Med Chem 123: 777-787 (2016) Article DOI: 10.1016/j.ejmech.2016.08.003 BindingDB Entry DOI: 10.7270/Q29Z96WM
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50197883 (CHEBI:78538 \| FX-1006 \| Tafamidis \| US10377729, Co...) Show SMILES OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.55E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...				Eur J Med Chem 123: 777-787 (2016) Article DOI: 10.1016/j.ejmech.2016.08.003 BindingDB Entry DOI: 10.7270/Q29Z96WM
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Transthyretin (Homo sapiens (Human))	BDBM50206387 (CHEMBL3898378) Show SMILES Cc1cc(cc(C)c1O)C#Cc1ccc2cc(N)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...				Eur J Med Chem 123: 777-787 (2016) Article DOI: 10.1016/j.ejmech.2016.08.003 BindingDB Entry DOI: 10.7270/Q29Z96WM
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50206385 (CHEMBL3976323) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...				Eur J Med Chem 123: 777-787 (2016) Article DOI: 10.1016/j.ejmech.2016.08.003 BindingDB Entry DOI: 10.7270/Q29Z96WM
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50206388 (CHEMBL3899454) Show SMILES Cc1cc(cc(C)c1O)C#Cc1ccc2ccccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...				Eur J Med Chem 123: 777-787 (2016) Article DOI: 10.1016/j.ejmech.2016.08.003 BindingDB Entry DOI: 10.7270/Q29Z96WM
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM50206386 (CHEMBL3987064) Show SMILES Cc1cc(cc(C)c1O)C#Cc1ccc2cc(O)ccc2n1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chungnam National University Curated by ChEMBL					Assay Description Inhibition of wild type TTR (unknown origin) assessed as inhibition of acid-mediated amyloidogenesis by measuring fibril formation preincubated with ...				Eur J Med Chem 123: 777-787 (2016) Article DOI: 10.1016/j.ejmech.2016.08.003 BindingDB Entry DOI: 10.7270/Q29Z96WM
Chungnam National University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%