BindingDB logo
myBDB logout

PubMed code 27665178

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))		BDBM50198670
PNG
(CHEMBL3960590)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1C
Show InChI InChI=1S/C17H14N2O3/c1-10-6-17(20)22-16-8-15(21-3)13(7-12(10)16)14-5-4-11(9-18)19(14)2/h4-8H,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198661
PNG
(CHEMBL3955849)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(C#N)n1CC1CCCCC1
Show InChI InChI=1S/C21H20N2O2/c22-13-18-8-9-19(23(18)14-15-4-2-1-3-5-15)16-6-10-20-17(12-16)7-11-21(24)25-20/h6-12,15H,1-5,14H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 31n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198660
PNG
(CHEMBL3928231)
Show SMILES CCCCCCn1c(ccc1-c1ccc2oc(=O)ccc2c1)C#N
Show InChI InChI=1S/C20H20N2O2/c1-2-3-4-5-12-22-17(14-21)8-9-18(22)15-6-10-19-16(13-15)7-11-20(23)24-19/h6-11,13H,2-5,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 34n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198677
PNG
(CHEMBL3929427)
Show SMILES CCn1c(ccc1-c1cc2c(C)cc(=O)oc2cc1OC)C#N
Show InChI InChI=1S/C18H16N2O3/c1-4-20-12(10-19)5-6-15(20)14-8-13-11(2)7-18(21)23-17(13)9-16(14)22-3/h5-9H,4H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198662
PNG
(CHEMBL3966957)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(C#N)n1Cc1ccccc1
Show InChI InChI=1S/C21H14N2O2/c22-13-18-8-9-19(23(18)14-15-4-2-1-3-5-15)16-6-10-20-17(12-16)7-11-21(24)25-20/h1-12H,14H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 56n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198682
PNG
(CHEMBL3918835)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc([nH]1)C#N
Show InChI InChI=1S/C18H17N3O2/c1-3-21(4-2)16-10-17-12(5-8-18(22)23-17)9-14(16)15-7-6-13(11-19)20-15/h5-10,20H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198667
PNG
(CHEMBL3963507)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(s1)C#N
Show InChI InChI=1S/C14H7NO2S/c15-8-11-3-5-13(18-11)10-1-4-12-9(7-10)2-6-14(16)17-12/h1-7H
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198678
PNG
(CHEMBL3891045)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc([nH]1)C#N
Show InChI InChI=1S/C14H8N2O2/c15-8-11-3-4-12(16-11)9-1-5-13-10(7-9)2-6-14(17)18-13/h1-7,16H
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198681
PNG
(CHEMBL3966515)
Show SMILES Cc1ccsc1-c1ccc2oc(=O)ccc2c1
Show InChI InChI=1S/C14H10O2S/c1-9-6-7-17-14(9)11-2-4-12-10(8-11)3-5-13(15)16-12/h2-8H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198680
PNG
(CHEMBL3983437)
Show SMILES Fc1cc(F)cc(Cn2c(ccc2-c2ccc3oc(=O)ccc3c2)C#N)c1
Show InChI InChI=1S/C21H12F2N2O2/c22-16-7-13(8-17(23)10-16)12-25-18(11-24)3-4-19(25)14-1-5-20-15(9-14)2-6-21(26)27-20/h1-10H,12H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198660
PNG
(CHEMBL3928231)
Show SMILES CCCCCCn1c(ccc1-c1ccc2oc(=O)ccc2c1)C#N
Show InChI InChI=1S/C20H20N2O2/c1-2-3-4-5-12-22-17(14-21)8-9-18(22)15-6-10-19-16(13-15)7-11-20(23)24-19/h6-11,13H,2-5,12H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198675
PNG
(CHEMBL3957000)
Show SMILES CCCCCCn1c(ccc1-c1cc2c(C)cc(=O)oc2cc1OC)C#N
Show InChI InChI=1S/C22H24N2O3/c1-4-5-6-7-10-24-16(14-23)8-9-19(24)18-12-17-15(2)11-22(25)27-21(17)13-20(18)26-3/h8-9,11-13H,4-7,10H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198674
PNG
(CHEMBL3965979)
Show SMILES Fc1c(F)c(F)c(Cn2c(ccc2-c2ccc3oc(=O)ccc3c2)C#N)c(F)c1F
Show InChI InChI=1S/C21H9F5N2O2/c22-17-13(18(23)20(25)21(26)19(17)24)9-28-12(8-27)3-4-14(28)10-1-5-15-11(7-10)2-6-16(29)30-15/h1-7H,9H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198664
PNG
(CHEMBL3954803)
Show SMILES Fc1ccc(Cn2c(ccc2-c2ccc3oc(=O)ccc3c2)C#N)cc1
Show InChI InChI=1S/C21H13FN2O2/c22-17-5-1-14(2-6-17)13-24-18(12-23)7-8-19(24)15-3-9-20-16(11-15)4-10-21(25)26-20/h1-11H,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 210n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198657
PNG
(CHEMBL3960113)
Show SMILES CCn1c(ccc1-c1ccc2oc(=O)ccc2c1)C#N
Show InChI InChI=1S/C16H12N2O2/c1-2-18-13(10-17)5-6-14(18)11-3-7-15-12(9-11)4-8-16(19)20-15/h3-9H,2H2,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198655
PNG
(CHEMBL3948334)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1Cc1ccccc1
Show InChI InChI=1S/C23H18N2O3/c1-15-10-23(26)28-22-12-21(27-2)19(11-18(15)22)20-9-8-17(13-24)25(20)14-16-6-4-3-5-7-16/h3-12H,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198676
PNG
(CHEMBL3936738)
Show SMILES Clc1ccsc1-c1ccc2oc(=O)ccc2c1
Show InChI InChI=1S/C13H7ClO2S/c14-10-5-6-17-13(10)9-1-3-11-8(7-9)2-4-12(15)16-11/h1-7H
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198668
PNG
(CHEMBL3955372)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc(C#N)n1C
Show InChI InChI=1S/C19H19N3O2/c1-4-22(5-2)17-11-18-13(6-9-19(23)24-18)10-15(17)16-8-7-14(12-20)21(16)3/h6-11H,4-5H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 240n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198654
PNG
(CHEMBL3927761)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc(C#N)n1CC
Show InChI InChI=1S/C20H21N3O2/c1-4-22(5-2)18-12-19-14(7-10-20(24)25-19)11-16(18)17-9-8-15(13-21)23(17)6-3/h7-12H,4-6H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198669
PNG
(CHEMBL3938469)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc([nH]1)C#N
Show InChI InChI=1S/C16H12N2O3/c1-9-5-16(19)21-15-7-14(20-2)12(6-11(9)15)13-4-3-10(8-17)18-13/h3-7,18H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198665
PNG
(CHEMBL3894599)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(C#N)n1Cc1ccc2ccccc2c1
Show InChI InChI=1S/C25H16N2O2/c26-15-22-9-10-23(20-7-11-24-21(14-20)8-12-25(28)29-24)27(22)16-17-5-6-18-3-1-2-4-19(18)13-17/h1-14H,16H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198656
PNG
(CHEMBL3946113)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(C#N)n1Cc1ccc(cc1)C#N
Show InChI InChI=1S/C22H13N3O2/c23-12-15-1-3-16(4-2-15)14-25-19(13-24)7-8-20(25)17-5-9-21-18(11-17)6-10-22(26)27-21/h1-11H,14H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198673
PNG
(CHEMBL3975572)
Show SMILES Cc1cc(=O)oc2cc(O)c(cc12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C16H12N2O3/c1-9-5-16(20)21-15-7-14(19)12(6-11(9)15)13-4-3-10(8-17)18(13)2/h3-7,19H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198659
PNG
(CHEMBL3946665)
Show SMILES CC(=O)c1ccc(s1)-c1ccc2oc(=O)ccc2c1
Show InChI InChI=1S/C15H10O3S/c1-9(16)13-5-6-14(19-13)11-2-4-12-10(8-11)3-7-15(17)18-12/h2-8H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 340n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198666
PNG
(CHEMBL3975017)
Show SMILES Cc1ccc(s1)-c1ccc2oc(=O)ccc2c1
Show InChI InChI=1S/C14H10O2S/c1-9-2-6-13(17-9)11-3-5-12-10(8-11)4-7-14(15)16-12/h2-8H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198663
PNG
(CHEMBL3975442)
Show SMILES [O-][N+](=O)c1ccc(Cn2c(ccc2-c2ccc3oc(=O)ccc3c2)C#N)cc1
Show InChI InChI=1S/C21H13N3O4/c22-12-18-7-8-19(15-3-9-20-16(11-15)4-10-21(25)28-20)23(18)13-14-1-5-17(6-2-14)24(26)27/h1-11H,13H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198671
PNG
(CHEMBL3924332)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1Cc1ccc(cc1)C#N
Show InChI InChI=1S/C24H17N3O3/c1-15-9-24(28)30-23-11-22(29-2)20(10-19(15)23)21-8-7-18(13-26)27(21)14-17-5-3-16(12-25)4-6-17/h3-11H,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 480n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50355216
PNG
(CHEMBL1835807)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccccc1
Show InChI InChI=1S/C19H19NO2/c1-3-20(4-2)17-13-18-15(10-11-19(21)22-18)12-16(17)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198684
PNG
(CHEMBL3920525)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1CC1CCCCC1
Show InChI InChI=1S/C23H24N2O3/c1-15-10-23(26)28-22-12-21(27-2)19(11-18(15)22)20-9-8-17(13-24)25(20)14-16-6-4-3-5-7-16/h8-12,16H,3-7,14H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 550n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198672
PNG
(CHEMBL3939561)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1Cc1ccc(F)cc1
Show InChI InChI=1S/C23H17FN2O3/c1-14-9-23(27)29-22-11-21(28-2)19(10-18(14)22)20-8-7-17(12-25)26(20)13-15-3-5-16(24)6-4-15/h3-11H,13H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 570n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198683
PNG
(CHEMBL3974043)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc(C#N)n1Cc1ccccc1
Show InChI InChI=1S/C25H23N3O2/c1-3-27(4-2)23-15-24-19(10-13-25(29)30-24)14-21(23)22-12-11-20(16-26)28(22)17-18-8-6-5-7-9-18/h5-15H,3-4,17H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 580n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198662
PNG
(CHEMBL3966957)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(C#N)n1Cc1ccccc1
Show InChI InChI=1S/C21H14N2O2/c22-13-18-8-9-19(23(18)14-15-4-2-1-3-5-15)16-6-10-20-17(12-16)7-11-21(24)25-20/h1-12H,14H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 790n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198658
PNG
(CHEMBL3903073)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc(C#N)n1CC#N
Show InChI InChI=1S/C20H18N4O2/c1-3-23(4-2)18-12-19-14(5-8-20(25)26-19)11-16(18)17-7-6-15(13-22)24(17)10-9-21/h5-8,11-12H,3-4,10H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 850n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198670
PNG
(CHEMBL3960590)
Show SMILES COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1C
Show InChI InChI=1S/C17H14N2O3/c1-10-6-17(20)22-16-8-15(21-3)13(7-12(10)16)14-5-4-11(9-18)19(14)2/h4-8H,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 990n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198668
PNG
(CHEMBL3955372)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc(C#N)n1C
Show InChI InChI=1S/C19H19N3O2/c1-4-22(5-2)17-11-18-13(6-9-19(23)24-18)10-15(17)16-8-7-14(12-20)21(16)3/h6-11H,4-5H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.36E+3n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50355216
PNG
(CHEMBL1835807)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccccc1
Show InChI InChI=1S/C19H19NO2/c1-3-20(4-2)17-13-18-15(10-11-19(21)22-18)12-16(17)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.42E+3n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50355216
PNG
(CHEMBL1835807)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccccc1
Show InChI InChI=1S/C19H19NO2/c1-3-20(4-2)17-13-18-15(10-11-19(21)22-18)12-16(17)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.54E+3n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human GR measured after 18 hrs by scintillation counting method

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))		BDBM50198668
PNG
(CHEMBL3955372)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccc(C#N)n1C
Show InChI InChI=1S/C19H19N3O2/c1-4-22(5-2)17-11-18-13(6-9-19(23)24-18)10-15(17)16-8-7-14(12-20)21(16)3/h6-11H,4-5H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human GR measured after 18 hrs by scintillation counting method

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Androgen receptor


(Homo sapiens (Human))		BDBM50355216
PNG
(CHEMBL1835807)
Show SMILES CCN(CC)c1cc2oc(=O)ccc2cc1-c1ccccc1
Show InChI InChI=1S/C19H19NO2/c1-3-20(4-2)17-13-18-15(10-11-19(21)22-18)12-16(17)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Binding affinity to human AR

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50355243
PNG
(CHEMBL1835836)
Show SMILES Cn1c(ccc1-c1ccc2oc(=O)ccc2c1)C#N
Show InChI InChI=1S/C15H10N2O2/c1-17-12(9-16)4-5-13(17)10-2-6-14-11(8-10)3-7-15(18)19-14/h2-8H,1H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.52E+4n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198673
PNG
(CHEMBL3975572)
Show SMILES Cc1cc(=O)oc2cc(O)c(cc12)-c1ccc(C#N)n1C
Show InChI InChI=1S/C16H12N2O3/c1-9-5-16(20)21-15-7-14(19)12(6-11(9)15)13-4-3-10(8-17)18(13)2/h3-7,19H,1-2H3
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.57E+4n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Displacement of [1,2,6,7-3H]progesterone from recombinant human GST-tagged PR-LBD (675 to 933 residues) expressed in baculovirus-infected insect cell...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50198679
PNG
(CHEMBL3937217)
Show SMILES O=c1ccc2cc(ccc2o1)-c1ccc(C#N)n1CC#N
Show InChI InChI=1S/C16H9N3O2/c17-7-8-19-13(10-18)3-4-14(19)11-1-5-15-12(9-11)2-6-16(20)21-15/h1-6,9H,8H2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.58E+4n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%