Found 5 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50206476
(CHEMBL3941777)Show SMILES Cl.NC(=N)N\N=C\c1ccc(cc1)-c1ccc(\C=N\Nc2ccccc2Br)cc1 Show InChI InChI=1S/C21H19BrN6/c22-19-3-1-2-4-20(19)27-25-13-15-5-9-17(10-6-15)18-11-7-16(8-12-18)14-26-28-21(23)24/h1-14,27H,(H4,23,24,28)/b25-13+,26-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes |
Bioorg Med Chem 25: 58-66 (2017)
Article DOI: 10.1016/j.bmc.2016.10.009
BindingDB Entry DOI: 10.7270/Q2T155NW |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50206474
(CHEMBL3944559)Show SMILES Cl.Cl.C\C(=N/NC(N)=N)c1ccc-2c(Cc3cc(ccc-23)C(\C)=N\NC(N)=N)c1 Show InChI InChI=1S/C19H22N8/c1-10(24-26-18(20)21)12-3-5-16-14(7-12)9-15-8-13(4-6-17(15)16)11(2)25-27-19(22)23/h3-8H,9H2,1-2H3,(H4,20,21,26)(H4,22,23,27)/b24-10+,25-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes |
Bioorg Med Chem 25: 58-66 (2017)
Article DOI: 10.1016/j.bmc.2016.10.009
BindingDB Entry DOI: 10.7270/Q2T155NW |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50206475
(CHEMBL3913789)Show SMILES Cl.NC(=N)N\N=C\c1ccc(cc1)-c1ccc(\C=N\Nc2ccccc2Cl)cc1 Show InChI InChI=1S/C21H19ClN6/c22-19-3-1-2-4-20(19)27-25-13-15-5-9-17(10-6-15)18-11-7-16(8-12-18)14-26-28-21(23)24/h1-14,27H,(H4,23,24,28)/b25-13+,26-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes |
Bioorg Med Chem 25: 58-66 (2017)
Article DOI: 10.1016/j.bmc.2016.10.009
BindingDB Entry DOI: 10.7270/Q2T155NW |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50206473
(CHEMBL3923854)Show SMILES Cl.NC(=N)N\N=C\c1ccc(cc1)-c1ccc(\C=N\Nc2ccc(F)cc2F)cc1 Show InChI InChI=1S/C21H18F2N6/c22-18-9-10-20(19(23)11-18)28-26-12-14-1-5-16(6-2-14)17-7-3-15(4-8-17)13-27-29-21(24)25/h1-13,28H,(H4,24,25,29)/b26-12+,27-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes |
Bioorg Med Chem 25: 58-66 (2017)
Article DOI: 10.1016/j.bmc.2016.10.009
BindingDB Entry DOI: 10.7270/Q2T155NW |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50206477
(CHEMBL3904792)Show SMILES Cl.NC(=N)N\N=C\c1ccc(cc1)-c1ccc(\C=N\Nc2ccc(F)cc2)cc1 Show InChI InChI=1S/C21H19FN6/c22-19-9-11-20(12-10-19)27-25-13-15-1-5-17(6-2-15)18-7-3-16(4-8-18)14-26-28-21(23)24/h1-14,27H,(H4,23,24,28)/b25-13+,26-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kentucky
Curated by ChEMBL
| Assay Description
Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes |
Bioorg Med Chem 25: 58-66 (2017)
Article DOI: 10.1016/j.bmc.2016.10.009
BindingDB Entry DOI: 10.7270/Q2T155NW |
More data for this
Ligand-Target Pair | |
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