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PubMed code 27889287

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuropilin-1


(Rattus norvegicus)		BDBM50208991
PNG
(CHEMBL3884233)
Show SMILES N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C22H38N8O6/c23-13-8-9-17(31)26-10-2-1-5-14(28-19(33)16-7-4-12-30(16)20(13)34)18(32)29-15(21(35)36)6-3-11-27-22(24)25/h13-16H,1-12,23H2,(H,26,31)(H,28,33)(H,29,32)(H,35,36)(H4,24,25,27)/t13-,14-,15-,16-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 158n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
Neuropilin-1


(Rattus norvegicus)		BDBM50208991
PNG
(CHEMBL3884233)
Show SMILES N[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C22H38N8O6/c23-13-8-9-17(31)26-10-2-1-5-14(28-19(33)16-7-4-12-30(16)20(13)34)18(32)29-15(21(35)36)6-3-11-27-22(24)25/h13-16H,1-12,23H2,(H,26,31)(H,28,33)(H,29,32)(H,35,36)(H4,24,25,27)/t13-,14-,15-,16-/m0/s1
PDB

UniProtKB/SwissProt

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CHEMBL
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 160n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
Neuropilin-1


(Rattus norvegicus)		BDBM50208993
PNG
(CHEMBL3885318)
Show SMILES NCCCC[C@@H]1NC(=O)[C@H](CCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)CCCCNC(=O)CC[C@H](NC(=O)[C@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C44H76N16O12/c45-19-3-1-10-28-40(68)60-24-8-14-32(60)38(66)55-26(36(64)58-30(42(71)72)12-6-22-53-44(49)50)15-17-33(61)51-20-4-2-9-25(46)39(67)59-23-7-13-31(59)37(65)56-27(35(63)57-28)16-18-34(62)54-29(41(69)70)11-5-21-52-43(47)48/h25-32H,1-24,45-46H2,(H,51,61)(H,54,62)(H,55,66)(H,56,65)(H,57,63)(H,58,64)(H,69,70)(H,71,72)(H4,47,48,52)(H4,49,50,53)/t25-,26-,27-,28-,29-,30-,31+,32+/m0/s1
PDB

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Article
PubMed
n/an/a 890n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
Neuropilin-1


(Rattus norvegicus)		BDBM50208993
PNG
(CHEMBL3885318)
Show SMILES NCCCC[C@@H]1NC(=O)[C@H](CCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)CCCCNC(=O)CC[C@H](NC(=O)[C@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C44H76N16O12/c45-19-3-1-10-28-40(68)60-24-8-14-32(60)38(66)55-26(36(64)58-30(42(71)72)12-6-22-53-44(49)50)15-17-33(61)51-20-4-2-9-25(46)39(67)59-23-7-13-31(59)37(65)56-27(35(63)57-28)16-18-34(62)54-29(41(69)70)11-5-21-52-43(47)48/h25-32H,1-24,45-46H2,(H,51,61)(H,54,62)(H,55,66)(H,56,65)(H,57,63)(H,58,64)(H,69,70)(H,71,72)(H4,47,48,52)(H4,49,50,53)/t25-,26-,27-,28-,29-,30-,31+,32+/m0/s1
PDB

UniProtKB/SwissProt

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CHEMBL
KEGG
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 890n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
Neuropilin-1


(Rattus norvegicus)		BDBM50208992
PNG
(CHEMBL3884504)
Show SMILES N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C21H36N8O6/c22-12-4-1-9-25-16(30)8-7-13(27-18(32)15-6-3-11-29(15)19(12)33)17(31)28-14(20(34)35)5-2-10-26-21(23)24/h12-15H,1-11,22H2,(H,25,30)(H,27,32)(H,28,31)(H,34,35)(H4,23,24,26)/t12-,13-,14-,15-/m0/s1
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
Neuropilin-1


(Rattus norvegicus)		BDBM50208995
PNG
(CHEMBL3885243)
Show SMILES N[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C21H36N8O6/c22-12-5-1-2-8-25-16(30)11-14(28-18(32)15-7-4-10-29(15)19(12)33)17(31)27-13(20(34)35)6-3-9-26-21(23)24/h12-15H,1-11,22H2,(H,25,30)(H,27,31)(H,28,32)(H,34,35)(H4,23,24,26)/t12-,13-,14-,15-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
Neuropilin-1


(Rattus norvegicus)		BDBM50208994
PNG
(CHEMBL3884096)
Show SMILES N[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@@H]2CCCN2C1=O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |r|
Show InChI InChI=1S/C22H38N8O6/c23-13-5-1-2-10-26-17(31)9-8-14(28-19(33)16-7-4-12-30(16)20(13)34)18(32)29-15(21(35)36)6-3-11-27-22(24)25/h13-16H,1-12,23H2,(H,26,31)(H,28,33)(H,29,32)(H,35,36)(H4,24,25,27)/t13-,14+,15+,16+/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of biotin labelled VEGF165 binding to rat recombinant NRP-1/Fc chimeric protein incubated for overnight by competitive ELISA method

Bioorg Med Chem 25: 597-602 (2017)


Article DOI: 10.1016/j.bmc.2016.11.024
BindingDB Entry DOI: 10.7270/Q27P91DW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%