Affinity Data by PubMed id=27994728

PubMed code 27994728

Found 23 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201022 (CHEMBL3897632 \| US10155727, Example 6 \| USRE49517,...) Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201028 (CHEMBL3954438 \| US10155727, Example 18 \| USRE49517...) Show SMILES FC(F)Oc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201023 (CHEMBL3927856 \| US10155727, Example 7 \| USRE49517,...) Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cn[nH]c2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.20	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201025 (CHEMBL3975087 \| US10155727, Example 26 \| USRE49517...) Show SMILES FC(F)c1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201026 (CHEMBL3983077 \| US10155727, Example 17 \| USRE49517...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201021 (CHEMBL3966599 \| US10155727, Example 2 \| USRE49517,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201024 (CHEMBL3936854 \| US10155727, Example 4 \| USRE49517,...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201022 (CHEMBL3897632 \| US10155727, Example 6 \| USRE49517,...) Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201023 (CHEMBL3927856 \| US10155727, Example 7 \| USRE49517,...) Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cn[nH]c2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201028 (CHEMBL3954438 \| US10155727, Example 18 \| USRE49517...) Show SMILES FC(F)Oc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201025 (CHEMBL3975087 \| US10155727, Example 26 \| USRE49517...) Show SMILES FC(F)c1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50201027 (CHEMBL3945735 \| US10155727, Example 30 \| USRE49517...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at Wistar rat brain NR2B assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured after 90 secs				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201024 (CHEMBL3936854 \| US10155727, Example 4 \| USRE49517,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201021 (CHEMBL3966599 \| US10155727, Example 2 \| USRE49517,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201027 (CHEMBL3945735 \| US10155727, Example 30 \| USRE49517...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Homo sapiens (Human))	BDBM50201026 (CHEMBL3983077 \| US10155727, Example 17 \| USRE49517...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Antagonist activity at human NR2B expressed in HEK293 cells co-expressing NRI assessed as inhibition of glutamate/glycine-induced Ca2+ flux measured ...				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201025 (CHEMBL3975087 \| US10155727, Example 26 \| USRE49517...) Show SMILES FC(F)c1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.75E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201021 (CHEMBL3966599 \| US10155727, Example 2 \| USRE49517,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201022 (CHEMBL3897632 \| US10155727, Example 6 \| USRE49517,...) Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201026 (CHEMBL3983077 \| US10155727, Example 17 \| USRE49517...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201024 (CHEMBL3936854 \| US10155727, Example 4 \| USRE49517,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201023 (CHEMBL3927856 \| US10155727, Example 7 \| USRE49517,...) Show SMILES FC(F)Oc1cc(ccc1Cl)-c1cnn(Cc2cn[nH]c2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50201028 (CHEMBL3954438 \| US10155727, Example 18 \| USRE49517...) Show SMILES FC(F)Oc1cc(ccc1F)-c1cnn(Cc2cc[nH]n2)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.35E+5	n/a	n/a	n/a	n/a	n/a	n/a
Dart Neuroscience LLC Curated by ChEMBL					Assay Description Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cell membranes after 90 mins by scintillation counting				ACS Med Chem Lett 7: 1018-1019 (2016) Article DOI: 10.1021/acsmedchemlett.6b00433 BindingDB Entry DOI: 10.7270/Q2CJ8GGN
Dart Neuroscience LLC Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%