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PubMed code 28408218

Compile data set for download or QSAR
Found 21 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240377
PNG
(CHEMBL4095373)
Show SMILES CC(C)(C)OC(=O)N1CC2CC(Oc3ncnc(Nc4ccc(cc4F)S(C)(=O)=O)c3[N+]([O-])=O)C1C2 |TLB:5:7:10.11:35,THB:12:11:7.8:35|
Show InChI InChI=1S/C22H26FN5O7S/c1-22(2,3)35-21(29)27-10-12-7-16(27)17(8-12)34-20-18(28(30)31)19(24-11-25-20)26-15-6-5-13(9-14(15)23)36(4,32)33/h5-6,9,11-12,16-17H,7-8,10H2,1-4H3,(H,24,25,26)
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n/an/an/an/a 78n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240384
PNG
(CHEMBL4065265)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CC2Nc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O |TLB:14:13:7.8:10,THB:5:7:12.13:10|
Show InChI InChI=1S/C22H27FN6O6S/c1-22(2,3)35-21(30)28-10-12-7-13(28)8-17(12)27-20-18(29(31)32)19(24-11-25-20)26-16-6-5-14(9-15(16)23)36(4,33)34/h5-6,9,11-13,17H,7-8,10H2,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a 4.90n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM29080
PNG
(CHEMBL280065 | N-oleoylethanolamine | Oleamide MEA...)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
Show InChI InChI=1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
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n/an/an/an/a 2.20E+3n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240392
PNG
(CHEMBL4063625)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Oc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |TLB:15:14:10.11:8.7,THB:5:7:14.13:10.11|
Show InChI InChI=1S/C23H29N5O7S/c1-23(2,3)35-22(29)27-12-14-5-8-16(27)11-18(14)34-21-19(28(30)31)20(24-13-25-21)26-15-6-9-17(10-7-15)36(4,32)33/h6-7,9-10,13-14,16,18H,5,8,11-12H2,1-4H3,(H,24,25,26)
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n/an/an/an/a 3.10n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240394
PNG
(CHEMBL4062726)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Nc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |TLB:15:14:11.10:7.8,THB:5:7:14.13:11.10|
Show InChI InChI=1S/C23H30N6O6S/c1-23(2,3)35-22(30)28-12-14-5-8-16(28)11-18(14)27-21-19(29(31)32)20(24-13-25-21)26-15-6-9-17(10-7-15)36(4,33)34/h6-7,9-10,13-14,16,18H,5,8,11-12H2,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a 6.40n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240394
PNG
(CHEMBL4062726)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Nc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |TLB:15:14:11.10:7.8,THB:5:7:14.13:11.10|
Show InChI InChI=1S/C23H30N6O6S/c1-23(2,3)35-22(30)28-12-14-5-8-16(28)11-18(14)27-21-19(29(31)32)20(24-13-25-21)26-15-6-9-17(10-7-15)36(4,33)34/h6-7,9-10,13-14,16,18H,5,8,11-12H2,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a 5.60n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240381
PNG
(CHEMBL4078851)
Show SMILES CC(C)(C)OC(=O)N1CC2CC(Nc3ncnc(Nc4ccc(cc4F)S(C)(=O)=O)c3[N+]([O-])=O)C1C2 |TLB:5:7:10.11:35,THB:12:11:7.8:35|
Show InChI InChI=1S/C22H27FN6O6S/c1-22(2,3)35-21(30)28-10-12-7-16(17(28)8-12)27-20-18(29(31)32)19(24-11-25-20)26-15-6-5-13(9-14(15)23)36(4,33)34/h5-6,9,11-12,16-17H,7-8,10H2,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a 236n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240391
PNG
(CHEMBL4067384)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CC2Nc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |TLB:14:13:7.8:10,THB:5:7:12.13:10|
Show InChI InChI=1S/C22H28N6O6S/c1-22(2,3)34-21(29)27-11-13-9-15(27)10-17(13)26-20-18(28(30)31)19(23-12-24-20)25-14-5-7-16(8-6-14)35(4,32)33/h5-8,12-13,15,17H,9-11H2,1-4H3,(H2,23,24,25,26)
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n/an/an/an/a 48n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240392
PNG
(CHEMBL4063625)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Oc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |TLB:15:14:10.11:8.7,THB:5:7:14.13:10.11|
Show InChI InChI=1S/C23H29N5O7S/c1-23(2,3)35-22(29)27-12-14-5-8-16(27)11-18(14)34-21-19(28(30)31)20(24-13-25-21)26-15-6-9-17(10-7-15)36(4,32)33/h6-7,9-10,13-14,16,18H,5,8,11-12H2,1-4H3,(H,24,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240390
PNG
(CHEMBL4088637)
Show SMILES CC(C)(C)OC(=O)N1CC2CC(Nc3ncnc(Nc4ccc(cc4)S(C)(=O)=O)c3[N+]([O-])=O)C1C2 |TLB:5:7:10.11:34,THB:12:11:7.8:34|
Show InChI InChI=1S/C22H28N6O6S/c1-22(2,3)34-21(29)27-11-13-9-16(17(27)10-13)26-20-18(28(30)31)19(23-12-24-20)25-14-5-7-15(8-6-14)35(4,32)33/h5-8,12-13,16-17H,9-11H2,1-4H3,(H2,23,24,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240381
PNG
(CHEMBL4078851)
Show SMILES CC(C)(C)OC(=O)N1CC2CC(Nc3ncnc(Nc4ccc(cc4F)S(C)(=O)=O)c3[N+]([O-])=O)C1C2 |TLB:5:7:10.11:35,THB:12:11:7.8:35|
Show InChI InChI=1S/C22H27FN6O6S/c1-22(2,3)35-21(30)28-10-12-7-16(17(28)8-12)27-20-18(29(31)32)19(24-11-25-20)26-15-6-5-13(9-14(15)23)36(4,33)34/h5-6,9,11-12,16-17H,7-8,10H2,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a 53n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240391
PNG
(CHEMBL4067384)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CC2Nc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |TLB:14:13:7.8:10,THB:5:7:12.13:10|
Show InChI InChI=1S/C22H28N6O6S/c1-22(2,3)34-21(29)27-11-13-9-15(27)10-17(13)26-20-18(28(30)31)19(23-12-24-20)25-14-5-7-16(8-6-14)35(4,32)33/h5-8,12-13,15,17H,9-11H2,1-4H3,(H2,23,24,25,26)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240396
PNG
(CHEMBL4086187)
Show SMILES CC(C)(C)OC(=O)N1CC2CC(Oc3ncnc(Nc4ccc(cc4)S(C)(=O)=O)c3[N+]([O-])=O)C1C2 |TLB:5:7:10.11:34,THB:12:11:7.8:34|
Show InChI InChI=1S/C22H27N5O7S/c1-22(2,3)34-21(28)26-11-13-9-16(26)17(10-13)33-20-18(27(29)30)19(23-12-24-20)25-14-5-7-15(8-6-14)35(4,31)32/h5-8,12-13,16-17H,9-11H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 315n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240387
PNG
(CHEMBL4098760)
Show SMILES [H][C@@]12CC[C@]([H])(C[C@@H]1Oc1ncnc(Nc3ccc(cc3F)S(C)(=O)=O)c1[N+]([O-])=O)N(C2)C(=O)OC(C)(C)C |r,TLB:8:7:3.2:31.30,THB:32:30:7.6:3.2|
Show InChI InChI=1S/C23H28FN5O7S/c1-23(2,3)36-22(30)28-11-13-5-6-14(28)9-18(13)35-21-19(29(31)32)20(25-12-26-21)27-17-8-7-15(10-16(17)24)37(4,33)34/h7-8,10,12-14,18H,5-6,9,11H2,1-4H3,(H,25,26,27)/t13-,14+,18-/m0/s1
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n/an/an/an/a 1.20n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240388
PNG
(CHEMBL4078300)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Nc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O |THB:5:7:10.11:14.13,15:14:10.11:8.7|
Show InChI InChI=1S/C23H29FN6O6S/c1-23(2,3)36-22(31)29-11-13-5-6-14(29)9-18(13)28-21-19(30(32)33)20(25-12-26-21)27-17-8-7-15(10-16(17)24)37(4,34)35/h7-8,10,12-14,18H,5-6,9,11H2,1-4H3,(H2,25,26,27,28)
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n/an/an/an/a 5.30n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240390
PNG
(CHEMBL4088637)
Show SMILES CC(C)(C)OC(=O)N1CC2CC(Nc3ncnc(Nc4ccc(cc4)S(C)(=O)=O)c3[N+]([O-])=O)C1C2 |TLB:5:7:10.11:34,THB:12:11:7.8:34|
Show InChI InChI=1S/C22H28N6O6S/c1-22(2,3)34-21(29)27-11-13-9-16(17(27)10-13)26-20-18(28(30)31)19(23-12-24-20)25-14-5-7-15(8-6-14)35(4,32)33/h5-8,12-13,16-17H,9-11H2,1-4H3,(H2,23,24,25,26)
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n/an/an/an/a>1.00E+3n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240384
PNG
(CHEMBL4065265)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CC2Nc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O |TLB:14:13:7.8:10,THB:5:7:12.13:10|
Show InChI InChI=1S/C22H27FN6O6S/c1-22(2,3)35-21(30)28-10-12-7-13(28)8-17(12)27-20-18(29(31)32)19(24-11-25-20)26-16-6-5-14(9-15(16)23)36(4,33)34/h5-6,9,11-13,17H,7-8,10H2,1-4H3,(H2,24,25,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240389
PNG
(CHEMBL4080761)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CC2Oc1ncnc(Nc2ccc(cc2)S(C)(=O)=O)c1[N+]([O-])=O |THB:14:13:10:8.7,5:7:10:12.13|
Show InChI InChI=1S/C22H27N5O7S/c1-22(2,3)34-21(28)26-11-13-9-15(26)10-17(13)33-20-18(27(29)30)19(23-12-24-20)25-14-5-7-16(8-6-14)35(4,31)32/h5-8,12-13,15,17H,9-11H2,1-4H3,(H,23,24,25)
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n/an/an/an/a 110n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240395
PNG
(CHEMBL4071750)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O |THB:5:7:10.11:14.13,15:14:10.11:8.7|
Show InChI InChI=1S/C23H28FN5O7S/c1-23(2,3)36-22(30)28-11-13-5-6-14(28)9-18(13)35-21-19(29(31)32)20(25-12-26-21)27-17-8-7-15(10-16(17)24)37(4,33)34/h7-8,10,12-14,18H,5-6,9,11H2,1-4H3,(H,25,26,27)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240378
PNG
(CHEMBL4067982)
Show SMILES CC(C)(C)OC(=O)N1CC2CC1CC2Oc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O |THB:14:13:10:8.7,5:7:10:12.13|
Show InChI InChI=1S/C22H26FN5O7S/c1-22(2,3)35-21(29)27-10-12-7-13(27)8-17(12)34-20-18(28(30)31)19(24-11-25-20)26-16-6-5-14(9-15(16)23)36(4,32)33/h5-6,9,11-13,17H,7-8,10H2,1-4H3,(H,24,25,26)
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n/an/an/an/a 5.60n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50240388
PNG
(CHEMBL4078300)
Show SMILES CC(C)(C)OC(=O)N1CC2CCC1CC2Nc1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O |THB:5:7:10.11:14.13,15:14:10.11:8.7|
Show InChI InChI=1S/C23H29FN6O6S/c1-23(2,3)36-22(31)29-11-13-5-6-14(29)9-18(13)28-21-19(30(32)33)20(25-12-26-21)27-17-8-7-15(10-16(17)24)37(4,34)35/h7-8,10,12-14,18H,5-6,9,11H2,1-4H3,(H2,25,26,27,28)
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n/an/an/an/a 1.80n/an/an/an/a



Jiangxi University of Traditional Chinese Medicine

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP stimulation measured after 60 mins by TR-FRET assay

Bioorg Med Chem Lett 27: 2515-2519 (2017)


Article DOI: 10.1016/j.bmcl.2017.03.092
BindingDB Entry DOI: 10.7270/Q2HH6N7Q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%